Search Hotels in Serra Mesa, San Diego

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
2 Dec - 3 Dec
Tomorrow
3 Dec - 4 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Serra Mesa, San Diego

Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6055)
"Always an amazing stay"
United States
Jana
The price is ₹12,090
₹16,612 total
includes taxes & fees
17 Dec - 18 Dec
Wyndham San Diego Bayside
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 10.8 km from Serra Mesa
9.0 out of 10, Wonderful, (3144)
"Great stay"
United States
Laurence
The price is ₹21,251
₹28,740 total
includes taxes & fees
28 Dec - 29 Dec
Hard Rock Hotel San Diego
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3487)
"Clean, staff friendly, great place for a stay"
United States
Derrick
The price is ₹11,192
₹12,333 total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Marina Gateway Hotel
Rooftop terrace
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 10.1 km from Serra Mesa
8.6 out of 10, Excellent, (2073)
"Room was spotless and location great. "
United States
James
The price is ₹9,393
₹10,891 total
includes taxes & fees
21 Dec - 22 Dec
Palihotel San Diego Gaslamp Quarter
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1246)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is ₹11,330
₹13,136 total
includes taxes & fees
17 Dec - 18 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (2684)
"Clean room, almost everything to walk to, recommended and will booked again. "
United States
Karla
The Horton Grand, Downtown/Gaslamp Quarter
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1448)
"Great stay, clean room. Staff was very friendly as well. Would stay again. "
United States
Alexis
The price is ₹11,209
₹12,996 total
includes taxes & fees
17 Dec - 18 Dec
The Bristol Hotel San Diego
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1016)
"Great room, clean, spacious and quiet. "
United States
Maria
The price is ₹9,941
₹11,308 total
includes taxes & fees
9 Dec - 10 Dec
Gaslamp Plaza Suites
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4.0 star property
5.7 km from Serra Mesa
9.2 out of 10, Wonderful, (2986)
"Friendly, staff was very helpful, great size rooms, and over all was an amazing stay"
United States
Naya
The price is ₹13,611
₹15,645 total
includes taxes & fees
17 Dec - 18 Dec
Legacy Resort Hotel & Spa
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
10 km from Serra Mesa
8.4 out of 10, Very good, (1662)
"Excellent stay all-around!"
United States
Nalani
The Sofia Hotel
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1006)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is ₹9,330
₹13,403 total
includes taxes & fees
17 Dec - 18 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1942)
"Great hotel"
United States
Farzana
The price is ₹14,224
₹21,196 total
includes taxes & fees
17 Dec - 18 Dec
Marriott Marquis San Diego Marina
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (702)
"Great staff, great location, great value. "
United States
Juan
The price is ₹8,159
₹9,459 total
includes taxes & fees
24 Dec - 25 Dec
The DEXTRO Little Italy, BW Premier Collection
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 star property
12.6 km from Serra Mesa
9.2 out of 10, Wonderful, (3175)
"The staff is friendly and the hotel is perfect!"
United States
Mark
The price is ₹9,833
₹11,303 total
includes taxes & fees
8 Dec - 9 Dec
Bay Club Hotel & Marina
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3.0 star property
5.4 km from Serra Mesa
8.0 out of 10, Very good, (2432)
"The room was excellent and the front desk staff very professional."
United States
Nelson
The price is ₹7,908
₹9,090 total
includes taxes & fees
4 Dec - 5 Dec
Days Inn by Wyndham San Diego Hotel Circle
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

4.0 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1054)
"Great room in a very convenient location"
Canada
Kristjan
The price is ₹10,583
₹14,864 total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Exterior
La Pensione Hotel

La Pensione Hotel

3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1918)
"Friendly staff, very nice room, great location!"
United States
Lisa
La Pensione Hotel
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

3.5 star property
Mission Bay, 10.1 km from Serra Mesa
9.0 out of 10, Wonderful, (3908)
"Staff was great, room was spotless, and map was easy to follow."
United States
Rosa
The price is ₹14,224
₹18,138 total
includes taxes & fees
17 Dec - 18 Dec
The Dana on Mission Bay
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

4.0 star property
29.1 km from Serra Mesa
9.2 out of 10, Wonderful, (1642)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Front of property
Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

2.0 star property
18.6 km from Serra Mesa
7.2 out of 10, Good, (1992)
"Good hotel. "
United States
Leonel
The price is ₹5,380
₹5,918 total
includes taxes & fees
3 Dec - 4 Dec
Hotel Palmeras Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Pacific Beach Park showing a beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Serra Mesa Hotel Reviews

Lafayette Hotel & Club

Lafayette Hotel & Club

10/10 Excellent
"Very hip place to stay with lobby bars always hopping. Rooms were cute and nice neighborhood."
Gregg 2-night trip
Posted 1 day ago
Lafayette Hotel & Club

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 39 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.