Serra Mesa Travel Guide
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
One of America’s largest urban green spaces, Balboa Park is an exciting spot packed with art, culture, and a world-renowned zoo.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Top hotels in Serra Mesa
Sheraton San Diego Resort
Spotless
Reviewed on 6 Jan 2026
Bay Club Hotel & Marina
Beautiful views from room 248! Great service throughout our stay from all the departments! Quiet, serenely quiet which we really enjoyed. Everything was clean, spacious, kept up and easy to navigate.
Reviewed on 6 Jan 2026
Courtyard by Marriott San Diego Downtown Little Italy
The big surprise is the Saturday farmers market right around the corner—such a great location!
Reviewed on 2 Jan 2026
The DEXTRO Little Italy, BW Premier Collection
Linen service for the room, staff, and fruit-infused water.
Reviewed on 5 Jan 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
The staff was kind and courteous , the rooms were clean, well and supplied with necessities. We received free cookies upon entry, the gym, indoor pool and jacuzzi were amazing. The only surprise that was quite significant and is not mentioned in the Expedia or hotel site description is that doubletree ...
Reviewed on 5 Jan 2026
Hilton San Diego Mission Valley
The room was nice, clean, and quiet.
Reviewed on 6 Jan 2026
Other neighbourhoods around Serra Mesa
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
Old Town San Diego
The abundant dining options and seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
