What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels can I expect to find in the Serra Mesa area?

Expedia has 37 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.

What can I see and do in this San Diego neighbourhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

The Best Hotels in Serra Mesa, San Diego - 2026 Updated Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Our top choices for Serra Mesa hotels

Outdoor pool, open 9:00 AM to 5:00 PM, pool cabanas (surcharge)

Sycuan Casino Resort

28.8 km from Serra Mesa

Bryan

₹12,370 total

includes taxes & fees

26 May - 27 May

Best Western Plus La Mesa San Diego

14 km from Serra Mesa

Sergio

₹14,435 total

includes taxes & fees

27 May - 28 May

Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

17.7 km from Serra Mesa

Hugo

₹9,282 total

includes taxes & fees

10 May - 11 May

Down duvets, Select Comfort beds, desk, laptop workspace

Ramada by Wyndham San Diego Poway Miramar

18.2 km from Serra Mesa

Ruffa Regina

₹9,660 total

includes taxes & fees

10 May - 11 May

Best Western Americana Inn

28.1 km from Serra Mesa

Nicole

₹13,259 total

includes taxes & fees

13 May - 14 May

Hampton Inn & Suites San Diego Airport Liberty Station

10.6 km from Serra Mesa

Alfred

₹19,924 total

includes taxes & fees

17 May - 18 May

La Quinta Inn by Wyndham San Diego Chula Vista

18.7 km from Serra Mesa

Royce

₹10,602 total

includes taxes & fees

25 May - 26 May

Holiday Inn Express San Diego Airport - Old Town by IHG

7.9 km from Serra Mesa

Joey L

₹15,444 total

includes taxes & fees

10 May - 11 May

Studio Suite, 1 King Bed with Sofa bed, Balcony | View from room

Sheraton San Diego Resort

10.1 km from Serra Mesa

Gregory

₹21,797 total

includes taxes & fees

13 May - 14 May

Breakfast and dinner served, American cuisine

Courtyard by Marriott San Diego El Cajon

16.6 km from Serra Mesa

Shana

₹16,415 total

includes taxes & fees

25 May - 26 May

Country Inn & Suites by Radisson, San Diego North, CA

11.7 km from Serra Mesa

Richard

₹17,585 total

includes taxes & fees

10 May - 11 May

Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

16.1 km from Serra Mesa

Jessica

₹15,646 total

includes taxes & fees

10 May - 11 May

Pleasant Inn

4.8 km from Serra Mesa

Laurent

₹10,224 total

includes taxes & fees

7 May - 8 May

Wyndham Garden San Diego Near SeaWorld

9 km from Serra Mesa

Andrea

₹9,261 total

includes taxes & fees

13 May - 14 May

The Encinitan Hotel & Suites

30.8 km from Serra Mesa

Valeria

₹14,961 total

includes taxes & fees

10 May - 11 May

Best Western San Diego/Miramar Hotel

10.1 km from Serra Mesa

Mercy

₹11,501 total

includes taxes & fees

7 May - 8 May

TownePlace Suites by Marriott San Diego Airport/Liberty Station

10.5 km from Serra Mesa

Stephanie

₹18,527 total

includes taxes & fees

25 May - 26 May

Holiday Inn Express San Diego South - Chula Vista by IHG

18.5 km from Serra Mesa

Sankara

₹13,275 total

includes taxes & fees

25 May - 26 May

California Suites Hotel

4.8 km from Serra Mesa

Stephon

₹8,759 total

includes taxes & fees

10 May - 11 May

Courtyard by Marriott San Diego Central

2.6 km from Serra Mesa

Chantal Rocio

₹13,326 total

includes taxes & fees

10 May - 11 May

View all properties

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

See properties

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

See properties

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

See properties

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

See properties

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

See properties

Top Serra Mesa Hotel Reviews

Hotel del Coronado, Curio Collection by Hilton

8/10 Good

"The room was clean and recently updated. The ocean view was lovely and did not disappoint. The property was very clean and well-maintained. A few negatives we did notice: Being located on a balcony room did have some noise that reached us from the restaurants and bars below. We did get a few ants in our room. As for parking - the fee to self park or valet are extremely ridiculous. You should be aware that it's a very high fee of $90-100/per day. "