Photo by Linda Cronan

Search Hotels in Medical Center District, San Antonio

Most hotels are fully refundable. Because flexibility matters.

Save an average of 15% on thousands of hotels with Expedia Rewards

Search over 2.9 million properties and 550 airlines worldwide

Filter by

Popular filters
Popular filters
Price per night
Guest rating
Guest rating
Property class
Payment type
Payment type
Property type
Property type
Area
Area
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveller experience
Traveller experience

Top Trending Hotels Near Medical Center District, San Antonio

Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2133)
"Location"
The price is ₹15,726
per night
26 May - 27 May
Omni La Mansion del Rio
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.2 out of 10, Wonderful, (2597)
"We took a quick two day trip to San Antonio and truly enjoyed our stay at this hotel. The location is excellent - you can literally walk out onto the riverwalk from the basement. The staff at the front desk were always helpful and friendly, and the free daily happy hour was awesome! The only negative I would add is that the property feels a little dated, but for a 48 hour stay, it was perfect for our needs. I would definitely stay again!"
The price is ₹11,347
per night
6 Jun - 7 Jun
Drury Plaza Hotel San Antonio Riverwalk
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1262)
"the location of the hotel"
The price is ₹15,969
per night
19 May - 20 May
Canopy by Hilton San Antonio Riverwalk
Save an average of 15% on thousands of hotels when you're signed in
Hotel Gibbs Downtown Riverwalk
3.5 star property
9.0 out of 10, Wonderful, (2810)
"Really fun historic hotel. Well kept up and maintained. Very friendly staff"
The price is ₹8,943
per night
19 May - 20 May
Hotel Gibbs Downtown Riverwalk
Courtyard by Marriott San Antonio Downtown/Market Square
3.0 star property
9.0 out of 10, Wonderful, (155)
"Bu kadar memnun kalacağımı tahmin etmiyordum. Ulaşımı kolay, temiz ve konforlu. Klasik bir otelden daha iyi geldi bana. Kendimi evimde gibi hissettim. "
The price is ₹10,354
per night
15 May - 16 May
Courtyard by Marriott San Antonio Downtown/Market Square
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2745)
"It was wonderful pool, spa, room excellent!"
The price is ₹13,293
per night
26 May - 27 May
Hotel Contessa
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1060)
"Close to the Riverwalk and very nice and clean"
The price is ₹15,724
per night
27 May - 28 May
Grand Hyatt San Antonio River Walk
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1102)
"Great place! "
The price is ₹31,650
per night
26 May - 27 May
La Cantera Resort & Spa
Hilton Palacio Del Rio
4.0 star property
8.8 out of 10, Excellent, (1541)
"Very nice hotel"
The price is ₹14,834
per night
26 May - 27 May
Hilton Palacio Del Rio
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1004)
"Great service; hotel is pretty; but a little inconvenience about repairing "
The price is ₹23,380
per night
19 May - 20 May
Hyatt Regency Hill Country Resort & Spa
JW Marriott San Antonio Hill Country Resort & Spa
4.5 star property
8.8 out of 10, Excellent, (1004)
"The resort is beautiful and the staff is very friendly. We had the best time with so much to do at the resort."
The price is ₹30,811
per night
27 May - 28 May
JW Marriott San Antonio Hill Country Resort & Spa
The Westin Riverwalk, San Antonio
4.0 star property
8.6 out of 10, Excellent, (1046)
"Nice"
The price is ₹15,330
per night
27 May - 28 May
The Westin Riverwalk, San Antonio
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (2992)
"Everything was good, I don’t have any complaint "
The price is ₹7,949
per night
19 May - 20 May
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard Marriott Riverwalk
3.0 star property
8.6 out of 10, Excellent, (1005)
"I had a great stay from, checking in early to breakfast and the valet. Evryone was great. "
The price is ₹9,156
per night
26 May - 27 May
Courtyard Marriott Riverwalk
Marriott San Antonio Riverwalk
4.0 star property
8.6 out of 10, Excellent, (1001)
"The location was wonderful "
The price is ₹15,188
per night
26 May - 27 May
Marriott San Antonio Riverwalk
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very good, (1320)
"Easy check in/out"
The price is ₹8,726
per night
2 Jun - 3 Jun
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
3.0 star property
8.4 out of 10, Very good, (1010)
"Everything is great except for the parking. I think parking should be free!!! "
The price is ₹10,220
per night
27 May - 28 May
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
3.0 star property
8.4 out of 10, Very good, (1478)
"Everyone at the front desk was helpful and provided great customer service. "
The price is ₹10,446
per night
26 May - 27 May
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
AC Hotel by Marriott San Antonio Riverwalk
4.0 star property
8.4 out of 10, Very good, (224)
"Room very clean, great location "
The price is ₹10,187
per night
19 May - 20 May
AC Hotel by Marriott San Antonio Riverwalk
Hampton Inn San Antonio-Downtown (River Walk)
2.5 star property
8.2 out of 10, Very good, (2637)
"Lots of people walking the area & homeless camps"
The price is ₹7,736
per night
19 May - 20 May
Hampton Inn San Antonio-Downtown (River Walk)
Don't see what you're looking for?
See all available properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

Hotels in top San Antonio neighborhoods Learn more about Medical Center District

Medical Center District hotels information

Number of reviews
28,378
Accommodation
4,357 hotels
Lowest Price
₹7,949
Highest Price
₹31,650

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.

How many hotels will I be able to find in Medical Center District?

Expedia has 127 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

Medical Center District Hotel Reviews