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Our top choices for Medical Center District hotels with a spa

A courtyard with stone planters, a small water feature, and outdoor seating with umbrellas.

1. Omni La Mansion del Rio

Omni La Mansion del Rio
4.0 star property
Downtown San Antonio
9.4 out of 10, Exceptional, (2,996 reviews)
  • cleanliness
    Luxurious riverside retreat with Mokara Spa's 17 treatment rooms and hot stone massages offers a rejuvenating escape in a historic setting.
The price is ₹17,164
₹20,747 total
includes taxes & fees
8 Nov - 9 Nov
Omni La Mansion del Rio
A modern indoor pool area with glass railings, seating, and a bar area with screens.

2. Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk
4.0 star property
Downtown San Antonio
9.2 out of 10, Wonderful, (2,335 reviews)
  • cleanliness
    Surrender to pure bliss at this riverside retreat where rejuvenating spa treatments complement a vibrant city centre location.
The price is ₹20,867
₹27,946 total
includes taxes & fees
18 Oct - 19 Oct
Hyatt Regency San Antonio Riverwalk
A modern bathroom with a large mirror, multiple sinks, and a view through a large window.

3. La Cantera Resort & Spa, a Signia Hilton Resort

La Cantera Resort & Spa, a Signia Hilton Resort
4.0 star property
La Cantera District
9.0 out of 10, Wonderful, (1,067 reviews)
  • cleanliness
    Recharge at this hill country sanctuary with 16 treatment rooms, sauna, and hot tub, plus 5 outdoor pools for ultimate relaxation.
The price is ₹27,411
₹38,777 total
includes taxes & fees
1 Nov - 2 Nov
La Cantera Resort & Spa, a Signia Hilton Resort
A reception area with a modern design, featuring a reception desk, two seating areas with chairs, and decorative plants.

4. Hilton Vacation Club Eilan Resort & Spa San Antonio

Hilton Vacation Club Eilan Resort & Spa San Antonio
4.5 star property
La Cantera District
8.4 out of 10, Very good, (1,003 reviews)
  • cleanliness
    Indulge in Mediterranean-inspired spa escapes with 10 specialised treatment rooms and outdoor areas for unparalleled relaxation.
The price is ₹12,330
₹17,494 total
includes taxes & fees
8 Nov - 9 Nov
Hilton Vacation Club Eilan Resort & Spa San Antonio
A poolside relaxation area with a massage table, lounge chairs, and a pool.

5. Hotel Contessa

Hotel Contessa
4.0 star property
Downtown San Antonio
9.0 out of 10, Wonderful, (3,986 reviews)
  • cleanliness
    Riverside spa escape with Ayurvedic treatments and outdoor therapy areas provides rejuvenating relaxation.
The price is ₹13,203
₹18,398 total
includes taxes & fees
9 Nov - 10 Nov
Hotel Contessa
A modern lobby with a dark wall, wooden slats, and a reception desk with pendant lights.

6. Kimpton Santo San Antonio - Riverwalk by IHG

Kimpton Santo San Antonio - Riverwalk by IHG
4.5 star property
Downtown San Antonio
9.6 out of 10, Exceptional, (1,274 reviews)
  • cleanliness
    Rejuvenating escapes await at this urban sanctuary where aromatherapy, body scrubs, and facials complement a rooftop pool oasis.
The price is ₹16,960
₹22,669 total
includes taxes & fees
18 Oct - 19 Oct
Kimpton Santo San Antonio - Riverwalk by IHG
A modern lobby with a reception desk, seating area, and potted plants.

7. The Monarch San Antonio, Curio Collection By Hilton

The Monarch San Antonio, Curio Collection By Hilton
5.0 star property
Downtown San Antonio
9.4 out of 10, Exceptional, (136 reviews)
The price is ₹30,593
₹36,432 total
includes taxes & fees
1 Nov - 2 Nov
The Monarch San Antonio, Curio Collection By Hilton
A modern, well-organized boutique hotel lobby with dark wood paneling, a central reception desk, and shelves displaying various items.

8. Plaza San Antonio Hotel & Spa, Autograph Collection

Plaza San Antonio Hotel & Spa, Autograph Collection
4.0 star property
Downtown San Antonio
9.4 out of 10, Exceptional, (989 reviews)
  • cleanliness
    Indulge in rejuvenating treatments at this elegant hotel with six specialised spa rooms and a serene poolside retreat in San Antonio.
The price is ₹16,960
₹23,199 total
includes taxes & fees
18 Oct - 19 Oct
Plaza San Antonio Hotel & Spa, Autograph Collection
A modern spa room with two massage tables, large windows, and a view of a cityscape.

9. Thompson San Antonio - Riverwalk, by Hyatt

Thompson San Antonio - Riverwalk, by Hyatt
5.0 star property
Downtown San Antonio
9.0 out of 10, Wonderful, (1,004 reviews)
  • cleanliness
    Experience the art deco elegance of this riverside retreat with seven luxurious spa treatment rooms and a refreshing outdoor pool.
The price is ₹18,580
₹25,928 total
includes taxes & fees
25 Oct - 26 Oct
Thompson San Antonio - Riverwalk, by Hyatt
A lobby with a staircase, seating area with patterned sofas, and a reception desk.

10. Holiday Inn Express San Antonio Rivercenter Area by IHG

Holiday Inn Express San Antonio Rivercenter Area by IHG
2.5 star property
Near East Side
8.8 out of 10, Excellent, (1,006 reviews)
  • cleanliness
    Sanctuary for wellness awaits at this hotel with a full-service spa, outdoor pool, and hot tub near the Alamodome.
The price is ₹9,242
₹10,791 total
includes taxes & fees
28 Oct - 29 Oct
Holiday Inn Express San Antonio Rivercenter Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Medical Center District

Pool
Breakfast included

Top Medical Center District Hotel Reviews

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

10/10 Excellent
"Super cool place to stay! Rooftop pool. Historic. Rooms are great! The bad...having to switch elevators if in the non "Alamo" tower. Also parking is $40 plus a night."
John 1-night trip
Posted 4 hours ago
Drury Plaza Hotel San Antonio Riverwalk

Frequently asked questions

Looking for a spa hotel in Medical Center District?
Forget the stress of everyday life and book yourself a lush spa hotel. Hotels with spas are the perfect way to break away from your routine and add a layer of luxury to your stay.
What's there to see and do in Medical Center District?
Experience Medical Center District and visit Six Flags Fiesta Texas, Alamo and Alamodome. If you have extra time while you're in the area, you might want to see Frost Bank Center and Wonderland of the Americas Mall.
What is a Medical Center District spa hotel?
Spa hotels in Medical Center District provide lodging and have an on-site spa which offers services such as facials as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.

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