What's it like in Lake Nona Medical City?

Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.

What's the best accommodation in Lake Nona Medical City?

Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona .

How many hotels will I find in Lake Nona Medical City?

Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.

If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.

What is there to do around this Orlando neighbourhood?

Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.

Search Hotels in Lake Nona Medical City, Orlando

Where to?

Dates

March 2026

11

April 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Our top choices for Lake Nona Medical City hotels

Courtyard Orlando Lake Nona

Lake Nona Medical City

Jana

₹17,629 total

includes taxes & fees

4 Apr - 5 Apr

Aloft Orlando Lake Nona

Lake Nona Medical City

Kendra

₹14,356 total

includes taxes & fees

5 Apr - 6 Apr

Residence Inn Orlando Lake Nona

Lake Nona Medical City

David

₹19,611 total

includes taxes & fees

5 Apr - 6 Apr

Meliá Orlando Celebration

26.1 km from Lake Nona Medical City

Brad

₹12,921 total

includes taxes & fees

30 Mar - 31 Mar

The Delaney Hotel

South Orange, 20.2 km from Lake Nona Medical City

Cate

Courtyard by Marriott Orlando Downtown

23.1 km from Lake Nona Medical City

John

₹14,872 total

includes taxes & fees

22 Mar - 23 Mar

Comfort Suites Downtown

24.8 km from Lake Nona Medical City

DWIGHT

₹12,330 total

includes taxes & fees

5 Apr - 6 Apr

Wyndham Lake Buena Vista – Disney Springs® Area

23.2 km from Lake Nona Medical City

Yukari

₹16,008 total

includes taxes & fees

22 Mar - 23 Mar

Wyndham Garden Lake Buena Vista – Disney Springs® Area

23.2 km from Lake Nona Medical City

Audrey Nou

₹13,964 total

includes taxes & fees

22 Mar - 23 Mar

Mini-fridge, microwave, coffee/tea maker

AC Hotel by Marriott Orlando Lake Buena Vista

22.5 km from Lake Nona Medical City

Michelle

₹11,764 total

includes taxes & fees

22 Mar - 23 Mar

Staybridge Suites Orlando at SeaWorld by IHG

19.7 km from Lake Nona Medical City

Dianne

₹12,084 total

includes taxes & fees

23 Mar - 24 Mar

Hilton Vacation Club Grand Beach Orlando

21.7 km from Lake Nona Medical City

Jeannette

₹16,990 total

includes taxes & fees

23 Mar - 24 Mar

Outdoor pool, pool loungers, lifeguards on site

Spectrum Resort Villas Orlando and Waterparks

33 km from Lake Nona Medical City

Donna

₹41,446 total

includes taxes & fees

22 Mar - 23 Mar

Westgate Vacation Villas Resort

31.4 km from Lake Nona Medical City

Jessica Latoya

₹12,390 total

includes taxes & fees

12 Mar - 13 Mar

Element Orlando Universal Blvd.

International Drive District, 20.7 km from Lake Nona Medical City

Sakinah

₹10,008 total

includes taxes & fees

22 Mar - 23 Mar

Days Inn by Wyndham Orlando Conv. Center/International Dr

International Drive District, 19.2 km from Lake Nona Medical City

Eva

₹7,994 total

includes taxes & fees

29 Mar - 30 Mar

Aloft Orlando Lake Buena Vista

21.7 km from Lake Nona Medical City

Terry

₹9,295 total

includes taxes & fees

22 Mar - 23 Mar

Fairfield Inn & Suites Orlando Lake Buena Vista

22.8 km from Lake Nona Medical City

Blenda

₹10,431 total

includes taxes & fees

5 Apr - 6 Apr

SPOT X Hotel Orlando/Intl Dr by The Red Collection

21 km from Lake Nona Medical City

Emel

₹9,097 total

includes taxes & fees

25 Mar - 26 Mar

Drury Plaza Hotel Orlando - Disney Springs Area

22.9 km from Lake Nona Medical City

BARRY

₹16,679 total

includes taxes & fees

5 Apr - 6 Apr

View all properties

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most. Learn more about Lake Nona Medical City

Aquatica which includes flowers, signage and a water park

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

See properties

This is the third park built at the Walt Disney World Resort, opening on May 1, 1989 as Disney-MGM Studios. Today, it's known as Disney's Hollywood Studios.

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

See properties

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

See properties

Hollywood Rip Ride Rock it at Universal Studios, Orlando.
Taken on a Sony a6000 with a 16 mm Sony lens.
# TroveonTuesday

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

See properties

Orlando downtown welcome sign with tropical scene; Shutterstock ID 99801884

Downtown Orlando

One of the most popular neighborhoods in Florida, this bustling area is full of art galleries, shops, bars and restaurants.

See properties

Top Lake Nona Medical City Hotel Reviews

Universal's Endless Summer Resort - Dockside Inn and Suites

10/10 Excellent

"This is my 2nd time staying at Dockside. I stay for the rooms, the food, convenience of getting to and from the parks and checking in/out is easy "

CoCo Key Hotel and Water Resort

2/10 Terrible

"Only good thing about this place is that it’s close by to many things . But do not book this place , building is old . Found roaches in my room , loud music in the pool with drunk people dancing and hogging the pool as if they own the place . Weekend proved to be full of ratchet rats . Waterpark is fun for kids but do not stay here unless you want a roach infested room . Night staff at the front were very professional when addressing a problem. But morning staff could care less they stare at you like seeing roaches is normal here . I won’t stay here again . "

Universal's Cabana Bay Beach Resort

10/10 Excellent

"The property is such a beautiful place that brings you back to your childhood memories. They have all the amenities you need for your family which was very accommodating and a shuttle to take you to universal studios right outside the hotel. This is our second time at this hotel and would definitely recommend it to anyone."

Westgate Lakes Resort & Spa Universal Studios Area

10/10 Excellent

"I really enjoyed the property my mom used to work at Westgate lake resorts and I used to drop her off and pick her up but I never stayed on the property well she died in 2015 so my recent stay was very nostalgic for me I thought about her the entire time I enjoyed the room so much I didn't go anywhere"

Search Hotels in Lake Nona Medical City, Orlando

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Lake Nona Medical City hotels

Courtyard Orlando Lake Nona

Aloft Orlando Lake Nona

Residence Inn Orlando Lake Nona

Meliá Orlando Celebration

The Delaney Hotel

Courtyard by Marriott Orlando Downtown

Comfort Suites Downtown

Wyndham Lake Buena Vista – Disney Springs® Area

Wyndham Garden Lake Buena Vista – Disney Springs® Area

AC Hotel by Marriott Orlando Lake Buena Vista

Staybridge Suites Orlando at SeaWorld by IHG

Hilton Vacation Club Grand Beach Orlando

Spectrum Resort Villas Orlando and Waterparks

Westgate Vacation Villas Resort

Element Orlando Universal Blvd.

Days Inn by Wyndham Orlando Conv. Center/International Dr

Aloft Orlando Lake Buena Vista

Fairfield Inn & Suites Orlando Lake Buena Vista

SPOT X Hotel Orlando/Intl Dr by The Red Collection

Drury Plaza Hotel Orlando - Disney Springs Area

Where to stay in Lake Nona Medical City

International Drive District

Bay Lake

Champions Gate

Florida Center

Downtown Orlando

Top Lake Nona Medical City Hotel Reviews

Universal's Endless Summer Resort - Dockside Inn and Suites

Frequently asked questions

Explore a world of travel with Expedia