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Top Luxury Southeast Jacksonville Hotels

Tricove Inn & Suites

4300 Salisbury Rd Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly motel in Jacksonville. Enjoy free Wi-Fi, free parking and a fitness centre. Our guests praise the helpful staff and the clean ...

7/10 Good! (1,000 reviews)

Good size room! Easy access from parking lot. Furniture a bit worn, but fine. TV small for the room, but I'm ok with that. I like the separate sink area outside the bathroom.

Reviewed on 5 Jan 2026

Red Roof Inn PLUS+ Jacksonville - Southpoint

6969 Lenoir Avenue E Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean ...

7.4/10 Good! (1,006 reviews)

Very nice staff.

Reviewed on 14 Jan 2026

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and a fitness centre. Our guests praise the helpful staff and the clean ...

7.8/10 Good! (1,796 reviews)

Excellent for the price and access to restaurants. Friendly personnel. Bed was amazingly comfortable. Great water pressure.

Reviewed on 24 Jan 2026

See all 551 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.