Southeast Jacksonville Luxury Holidays 2026

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Top Luxury Southeast Jacksonville Hotels

Tricove Inn & Suites

4300 Salisbury Rd Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly motel in Jacksonville. Enjoy free Wi-Fi, free parking and a fitness centre. Our guests praise the helpful staff and the clean ...

Red Roof Inn PLUS+ Jacksonville - Southpoint

6969 Lenoir Avenue E Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean ...

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

7.8/10 Good! (2,075 reviews)

"Service was great people were friendly and helpful. Clean. Safe area and easy to travel. Perfect for being a half way point to the beach or down town. Stayed here multiple times and would again. Only down side elevator was down this time, no big deal."

Reviewed on 28 Sept 2026

See all 604 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.