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Top Luxury Southeast Jacksonville Hotels

Tricove Inn & Suites

4300 Salisbury Rd Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly motel in Jacksonville. Enjoy free Wi-Fi, free parking and a fitness centre. Our guests praise the helpful staff and the clean ...

7.4/10 Good! (1,004 reviews)

"Clean room friendly staff, accessible parking..."

Reviewed on 26 Jun 2026

Red Roof Inn PLUS+ Jacksonville - Southpoint

6969 Lenoir Avenue E Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean ...

7.6/10 Good! (1,001 reviews)

"I keep coming back to this place because of their pet friendly accommodations. Staff are great but I noticed this time that the cleanliness in the last room we stayed in was not up to par. Dirty and quite smelly."

Reviewed on 26 Jun 2026

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8/10 Very good! (1,916 reviews)

"Management is terrible, found a dirty wash cloth on the shower curtain pole, toilet water running all night , AC rattling all night, draw on night stand keeps opening. Manager not there until 9:30 am , I had an early checkout and left a message from front desk for manager to call back and he never ..."

Reviewed on 26 Jun 2026

See all 587 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.