Search Adults Only Resorts & Hotels in Isle of Palms
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Isle of Palms Adults Only Resorts & Hotels
Our top choices for Isle of Palms adults-only hotels
1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic AreaIsle of Palms
9.4 out of 10, Exceptional, (571 reviews)
"Great prices for the rooms and amenities they come with. Best hotel breakfast Ive seen in a while- all the extras and more!"
Laura
The price is ₹13,018
₹14,776 total
includes taxes & fees
15 Aug - 16 Aug
2. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo ClinicGolden Glades - The Woods
9.0 out of 10, Wonderful, (1,011 reviews)
"Nice friendly hotel. Front desk so delightful, the breakfast staff goes above and beyond making sure everything is filled for breakfast ."
Grace
The price is ₹12,175
₹13,818 total
includes taxes & fees
16 Aug - 17 Aug
3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHGJacksonville
9.0 out of 10, Wonderful, (1,010 reviews)
"Very helpful staff and nice view to the golf course."
Jorge
The price is ₹10,094
₹11,457 total
includes taxes & fees
6 Sept - 7 Sept
4. Holiday Inn Express Jacksonville Beach by IHG
Holiday Inn Express Jacksonville Beach by IHGJacksonville Beach
9.2 out of 10, Wonderful, (1,011 reviews)
"Great staff and location"
Tiffany
The price is ₹11,234
₹12,751 total
includes taxes & fees
16 Aug - 17 Aug
5. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic AreaJacksonville Beach
9.0 out of 10, Wonderful, (1,199 reviews)
"Attentive and friendly staff, good location, generous breakfast"
Dagmar Maria
The price is ₹11,411
₹12,951 total
includes taxes & fees
1 Sept - 2 Sept
6. TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville EastGolden Glades - The Woods
9.2 out of 10, Wonderful, (645 reviews)
"Clean place"
grant
The price is ₹11,332
₹12,862 total
includes taxes & fees
6 Sept - 7 Sept
7. Hilton Jacksonville at Mayo Clinic near Beaches
Hilton Jacksonville at Mayo Clinic near BeachesJacksonville
9.4 out of 10, Exceptional, (309 reviews)
"Great hotel and very convenient to Mayo."
Margaret
The price is ₹14,368
₹16,307 total
includes taxes & fees
7 Sept - 8 Sept
8. Hyatt Studios Jacksonville/St Johns Town Center
Hyatt Studios Jacksonville/St Johns Town CenterSouthside
9.6 out of 10, Exceptional, (151 reviews)
"Ladies at the front desk were amazing! Very happy with our stay "
Kate
The price is ₹10,473
₹11,887 total
includes taxes & fees
8 Sept - 9 Sept
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Isle of Palms Hotel Reviews
Explore a world of travel with Expedia
- Aparthotels in Amelia Island
- Amelia National Hotels
- Hotels near American Beach
- American Beach Hotels
- Hotels with Hot Tubs in Arlington
- Beach Resorts & in Atlantic Beach
- Hotels near Atlantic Beach
- Hotels Suites in Baymeadows
- Baymeadows Hotels
- Beach Resorts & in Beach Haven
- Luxury Hotels in Biscayne
- Brooklyn Hotels
- Hotels near Castillo de San Marcos National Monument
- Deerwood Hotels
- Sports Hotels in Downtown Jacksonville
- Cheap Hotels in Downtown Jacksonville
- Hotels Suites in Downtown Jacksonville
- Riverside Hotels in Downtown Jacksonville
- Scuba Diving Hotels in Downtown Jacksonville
- Downtown Jacksonville Hotels
- Hotels near Fernandina Beach
- Green Cove Springs Hotels
- Hotels near HCA Florida Memorial Hospital
- Aparthotels in Jacksonville Beach
- Resorts in Jacksonville Beach
- Hotels Suites in Jacksonville Beach
- Hotels with Views in Jacksonville Beach
- Romantic Hotels in Jacksonville Beach
- Jacksonville Beach Hotels
- Aparthotels in Jacksonville Coast
- Adults Only Resorts & in Jacksonville Coast
- Beach Resorts & in Jacksonville Coast
- Golf Hotels in Jacksonville Coast
- Hotels with Views in Jacksonville Coast
- Hotels with Balcony in Jacksonville Coast
- Motels in Jacksonville Coast
- Hostels in Jacksonville
- Beach Resorts & in Jacksonville
- Boutique Hotels in Jacksonville
- Cheap Hotels in Jacksonville
- Hotels with Airport Transfers in Jacksonville
- Hotels with Early Check-in in Jacksonville
- Luxury Hotels in Jacksonville
- Scuba Diving Hotels in Jacksonville
- Jacksonville Hotels
- Hotels near Jacksonville Naval Air Station
- Town Houses in Jacksonville
- Hotels near Jacksonville Zoo and Gardens
- Mandarin Hotels
- Hotels near Mayo Clinic Florida
- Hotels near Mayport Naval Station
- Hotels near Metropolitan Park
- Hotels near Mickler Beach
- Cheap Hotels in Nocatee
- Hotels near Omni Amelia Island Resort Golf
- Orange Park Hotels
- Hotels near Orange Park Mall
- Luxury Hotels in Phoenix
- Aparthotels in Ponte Vedra
- Resorts in Ponte Vedra Beach
- Hotels Suites in Ponte Vedra Beach
- Hotels with Hot Tubs in Ponte Vedra Beach
- Hotels near Prime F. Osborn III Convention Center
- Riverside Hotels
- San Marco Hotels
- Hotels near South Ponte Vedra Beach
- Business Hotels in South Ponte Vedra Beach
- South Ponte Vedra Beach Hotels
- Aparthotels in Southeast Jacksonville
- Marriott Hotels & Resorts in Southpoint
- B&B in St. Augustine
- Hostels in St. Johns
- St. Johns Hotels
- Hotels near St. Johns Town Center
- Hotels near University of North Florida
- Vilano Beach Hotels
- Hotels near VyStar Veterans Memorial Arena
- Hotels near World Golf Village
- Car hire Atlantic Beach
- Car hire near Brooklyn
- Car hire near Downtown Jacksonville
- Car hire Jacksonville Beach
- Rental cars Jacksonville Intl. airport
- Car hire near Jacksonville University
- Car hire near Jacksonville Zoo and Gardens
- Car hire near Jacksonville
- Car hire near Morocco Shrine Center
- Rental cars Northeast Florida Regional airport
- Car hire near Omni Amelia Island Resort Golf
- Car hire near Phoenix
- Car hire near Roosevelt Boulevard and San Juan Shopping Center
- Car hire near San Jose Plaza Shopping Center
- Car hire near San Jose
- Car hire near Sawgrass Village
- Car hire near St. Johns Town Center