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Check prices for these dates

Next weekend
6 Nov - 8 Nov
In two weeks
13 Nov - 15 Nov

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Our top choices for Mayo Clinic Florida hotels

A modern restaurant with a bar area, wooden ceiling, and large windows.

1. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
0.8 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (389 reviews)
"A beautiful place will stay there again"
United States
Brandy
The price is ₹15,174
₹17,222 total
includes taxes & fees
22 Nov - 23 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.4 km from Mayo Clinic Florida
8.4 out of 10, Very good, (800 reviews)
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
United States
Patricia
The price is ₹14,433
₹16,382 total
includes taxes & fees
7 Nov - 8 Nov
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (614 reviews)
"Had a great experience while here. Rooms were clean and spacious. Will definitely stay here again."
United States
LISA
The price is ₹13,958
₹15,843 total
includes taxes & fees
20 Nov - 21 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

4. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
8.8 out of 10, Excellent, (4,655 reviews)
"really enjoyed our stay"
United States
Lavorus
The price is ₹13,615
₹15,453 total
includes taxes & fees
3 Nov - 4 Nov
Margaritaville Jacksonville Beach
A covered entrance with a dark tiled floor, white columns, and a green bench.

5. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
4.2 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,251 reviews)
"Excellent place to stay if spending time at Mayo"
United States
Jeffrey
The price is ₹11,219
₹12,733 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
A buffet with multiple self-service stations, including omelets and other prepared foods.

6. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1,007 reviews)
"Great place to stay"
United States
Bobby
The price is ₹10,426
₹11,834 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express Jacksonville Beach by IHG
A lobby with a reception desk, seating area, and a staircase.

7. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,024 reviews)
"Great bed and breakfast"
United States
Gregory
The price is ₹9,970
₹11,316 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A pool with a waterfall feature, surrounded by large rock formations.

8. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
3.0 star property
6.3 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (2,511 reviews)
"Great stay"
United States
Maya
The price is ₹15,255
₹17,314 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Jacksonville Beach/Oceanfront
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

9. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (667 reviews)
"The room was very clean and comfortable. It would be nice to have the breakfast time last longer than 9:00am though."
United States
Lana
The price is ₹12,059
₹13,687 total
includes taxes & fees
22 Nov - 23 Nov
TownePlace Suites by Marriott Jacksonville East
A hotel lobby with a bar area, seating arrangements, and a reception desk.

10. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,003 reviews)
"Loved the room, and the little cheese omelets at breakfast were good!"
United States
Kerry
The price is ₹12,143
₹13,782 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
A terrace with wooden tables and chairs, overlooking a beach and a pier.

11. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (816 reviews)
"Lovely hotel"
United States
Ovidiu
The price is ₹16,062
₹18,230 total
includes taxes & fees
22 Nov - 23 Nov
Springhill Suites By Marriott Jacksonville Beach Oceanfront
A living room with a sofa, chairs, a coffee table, a lamp, and a view of the ocean.

12. Dune House Hotel & Spa

Dune House Hotel & Spa
4.5 star property
8 km from Mayo Clinic Florida
8.8 out of 10, Excellent, (1,004 reviews)
"The staff was over the top!. Check in was so easy . Valet parking and lots of shops nearby."
United States
Debi
The price is ₹17,153
₹23,551 total
includes taxes & fees
23 Nov - 24 Nov
Dune House Hotel & Spa
A balcony with a view of the beach, a wooden walkway, and a chair.

13. Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
6.4 km from Mayo Clinic Florida
8.4 out of 10, Very good, (1,001 reviews)
"Great accommodations."
United States
John
The price is ₹14,897
₹16,908 total
includes taxes & fees
23 Nov - 24 Nov
Courtyard by Marriott Jacksonville Beach Oceanfront
A beach with a sandy shore, waves, and buildings in the background.

14. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,003 reviews)
"Would stay again"
United States
Williams
The price is ₹11,565
₹13,126 total
includes taxes & fees
3 Nov - 4 Nov
Best Western Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
9.4
Exceptional
614 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
9.2
Wonderful
389 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
9.0
Wonderful
1,003 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
9.0
Wonderful
1,024 reviews
View
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
8.4
Very good
800 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Amazing! Will definitely stay again! Far exceeded my expectations! Thank you for a wonderful visit!"
JESSICA 2-night trip
Posted 2 hours ago
Margaritaville Jacksonville Beach

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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