The Best Hotels Closest to Mayo Clinic Florida in Jacksonville - 2026 Updated Prices

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Our top choices for Mayo Clinic Florida hotels

1. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Kristen

₹16,441

₹18,661 total

includes taxes & fees

26 Sept - 27 Sept

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Troy

₹14,582

₹16,551 total

includes taxes & fees

26 Sept - 27 Sept

3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

₹13,115

₹14,886 total

includes taxes & fees

18 Oct - 19 Oct

4. Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

Melissa

₹14,318

₹16,251 total

includes taxes & fees

20 Sept - 21 Sept

Standard Room, 2 Queen Beds, Accessible (Accessible Tub) | In-room safe, desk, laptop workspace, blackout curtains

5. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Jose

₹11,323

₹12,851 total

includes taxes & fees

22 Sept - 23 Sept

6. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

4.2 km from Mayo Clinic Florida

Hollye

₹11,335

₹12,865 total

includes taxes & fees

18 Oct - 19 Oct

2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, pool loungers

On the beach, white sand, beach towels, snorkelling

7. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

₹16,227

₹18,418 total

includes taxes & fees

19 Oct - 20 Oct

Studio, 1 King Bed with Sofa bed | Desk, iron/ironing board, free cots/infant beds, free WiFi

8. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

₹11,896

₹13,502 total

includes taxes & fees

18 Oct - 19 Oct

In-room safe, desk, blackout curtains, iron/ironing board

9. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

Jami

₹8,922

₹10,126 total

includes taxes & fees

18 Oct - 19 Oct

10. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

₹10,503

₹11,921 total

includes taxes & fees

18 Oct - 19 Oct

11. Springhill Suites By Marriott Jacksonville Beach Oceanfront

5.8 km from Mayo Clinic Florida

Ovidiu

₹16,231

₹18,422 total

includes taxes & fees

4 Oct - 5 Oct

Standard Room, 1 King Bed, Balcony, Oceanfront (with Sofabed) | Balcony view

12. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Shawna

₹12,521

₹14,212 total

includes taxes & fees

20 Sept - 21 Sept

Premium bedding, pillow-top beds, minibar, in-room safe

Room, 1 King Bed, Balcony, Oceanfront (Dune House Preview) | Premium bedding, pillow-top beds, minibar, in-room safe

13. Dune House Hotel & Spa

8 km from Mayo Clinic Florida

Hanadi

₹19,839

₹26,644 total

includes taxes & fees

14 Oct - 15 Oct

Suite, 1 Bedroom, Ocean View | View from room

Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers

14. Courtyard by Marriott Jacksonville Beach Oceanfront

6.4 km from Mayo Clinic Florida

Marc

₹15,849

₹17,989 total

includes taxes & fees

1 Oct - 2 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.6 Exceptional 599 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.4 Exceptional 354 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 658 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,006 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,000 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

10/10 Excellent

"Amazing!!"

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Springhill Suites By Marriott Jacksonville Beach Oceanfront

10/10 Excellent

"Beautiful room with a view. Great location and great restaurant on site!"

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

10/10 Excellent

"Nice, clean room. Close to the Mayo Clinic."

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent

"Great location close to the beach. Super well maintained facility. Everything was great!"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 46 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 46 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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Our top choices for Mayo Clinic Florida hotels

1. Hilton Jacksonville at Mayo Clinic near Beaches

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches