Search Hotels in Serra Mesa, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Serra Mesa hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,902 reviews)
"Great stay"
United States
Zuhair
The price is ₹9,293
₹11,353 total
includes taxes & fees
11 May - 12 May
Sycuan Casino Resort

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
14 km from Serra Mesa
8.4 out of 10, Very good, (1,018 reviews)
"Clean room, clean property, kind staff, great breakfast, very spacious rooms."
United States
Sergio
The price is ₹12,979
₹14,277 total
includes taxes & fees
26 May - 27 May
Best Western Plus La Mesa San Diego

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
17.7 km from Serra Mesa
7.8 out of 10, Good, (1,010 reviews)
"Clean rooms Good breakfast Excellent staff"
United States
Dulce j
The price is ₹8,332
₹9,181 total
includes taxes & fees
11 May - 12 May
Days Inn by Wyndham San Diego-East/El Cajon

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.0 out of 10, Good, (1,008 reviews)
"A very nice stay I would recommend "
United States
Iris
The price is ₹8,595
₹9,455 total
includes taxes & fees
9 May - 10 May
Ramada by Wyndham San Diego Poway Miramar

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
9.0 out of 10, Wonderful, (1,271 reviews)
"Clean room, nice staff, a simple breakfast, and free parking on site."
United States
Nicole
The price is ₹9,621
₹10,944 total
includes taxes & fees
28 May - 29 May
Best Western Americana Inn

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,716 reviews)
"Great location, clean room plus friendly staffes."
United States
Alfred
The price is ₹16,743
₹19,246 total
includes taxes & fees
7 Jun - 8 Jun
Hampton Inn & Suites San Diego Airport Liberty Station

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,618 reviews)
"Great stay"
United States
Helda
The price is ₹9,533
₹10,487 total
includes taxes & fees
25 May - 26 May
La Quinta Inn by Wyndham San Diego Chula Vista

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,067 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is ₹13,289
₹15,275 total
includes taxes & fees
13 May - 14 May
Holiday Inn Express San Diego Airport - Old Town by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,527 reviews)
"Great place to stay "
United States
Tonya
The price is ₹15,928
₹23,076 total
includes taxes & fees
25 May - 26 May
Sheraton San Diego Resort

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
16.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,005 reviews)
"Really nice staff and great hotel!"
Canada
Shana
The price is ₹14,734
₹16,236 total
includes taxes & fees
25 May - 26 May
Courtyard by Marriott San Diego El Cajon

Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
3.0 star property
11.7 km from Serra Mesa
9.0 out of 10, Wonderful, (1,488 reviews)
"Comfortable place to stay with good breakfast."
United States
David
The price is ₹16,027
₹18,422 total
includes taxes & fees
17 May - 18 May
Country Inn & Suites by Radisson, San Diego North, CA

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,817 reviews)
"Great resort "
United States
Ines
The price is ₹12,158
₹13,397 total
includes taxes & fees
10 May - 11 May
Best Western Plus Marina Gateway Hotel

Pleasant Inn

Pleasant Inn
2.5 star property
4.8 km from Serra Mesa
8.6 out of 10, Excellent, (1,392 reviews)
"Clean room nice staff"
United States
Elizabeth
The price is ₹8,812
₹10,112 total
includes taxes & fees
10 May - 11 May
Pleasant Inn

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,235 reviews)
"Great overall stay. Would stay again. "
United States
German
The price is ₹7,969
₹9,160 total
includes taxes & fees
31 May - 1 Jun
Wyndham Garden San Diego Near SeaWorld

The Encinitan Hotel & Suites

The Encinitan Hotel & Suites
3.0 star property
30.8 km from Serra Mesa
8.2 out of 10, Very good, (1,536 reviews)
"Really great location and kind staff!! "
Canada
Sarah
The price is ₹11,517
₹14,105 total
includes taxes & fees
14 May - 15 May
The Encinitan Hotel & Suites

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
8.0 out of 10, Very good, (1,318 reviews)
"Best hotel and the location "
United States
Mercy
The price is ₹10,213
₹11,739 total
includes taxes & fees
10 May - 11 May
Best Western San Diego/Miramar Hotel

TownePlace Suites by Marriott San Diego Airport/Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station
3.0 star property
10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1,009 reviews)
"Love it great place"
United States
Derek
The price is ₹15,942
₹18,325 total
includes taxes & fees
25 May - 26 May
TownePlace Suites by Marriott San Diego Airport/Liberty Station

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,134 reviews)
"The room was lovely and clean friendly staff, nice breakfast"
United Kingdom
Niki Andrew
The price is ₹11,216
₹12,337 total
includes taxes & fees
25 May - 26 May
Holiday Inn Express San Diego South - Chula Vista by IHG

California Suites Hotel

California Suites Hotel
2.0 star property
4.8 km from Serra Mesa
7.8 out of 10, Good, (2,536 reviews)
"Very comfortable, nice pool and hot tub, quiet, pretty location, and close to lots of stuff! Would stay here again! "
United States
Stephon
The price is ₹7,549
₹8,663 total
includes taxes & fees
17 May - 18 May
California Suites Hotel

Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
2.6 km from Serra Mesa
8.8 out of 10, Excellent, (1,007 reviews)
"Good hotel for price point"
United States
Arturo
The price is ₹13,294
₹15,281 total
includes taxes & fees
28 May - 29 May
Courtyard by Marriott San Diego Central
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 37 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

Explore a world of travel with Expedia