TOP Luxury Hotels in Southeast Jacksonville, FL for 2026

A stone wall with a tower, palm trees, and calm water.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Southeast Jacksonville Luxury Hotels

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Southeast Jacksonville luxury hotels

A modern restaurant with a bar area, wooden ceiling, and large windows.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

1. Hilton Jacksonville at Mayo Clinic near Beaches

Jacksonville

₹16,310

₹18,512 total

includes taxes & fees

17 Oct - 18 Oct

View all properties

Top Southeast Jacksonville Hotel Reviews

Wyndham Garden Jacksonville

8/10 Good

"Nice room for the price. Clean and comfortable."

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

8/10 Good

"Missed coffee in the room. Bad idea."

Baymont by Wyndham Jacksonville/Butler Blvd

10/10 Excellent

"Last minute overnight stay was great. Easy efficient checkin and the staff was very professional and kind. Our room was clean and the bed was comfortable. We very content with breakfast options and check out. Location is close to restaurants. The amenities in the room were helpful too. Suggestion for roo is oil hinges on the bathroom door and a noise in the a/c but otherwise a great stay and will be back. We will recommend to family and friends if in the Jacksonville area."

Explore a world of travel with Expedia

Book Luxury Hotels in Southeast Jacksonville on Expedia.com

Search Luxury Hotels in Southeast Jacksonville

Change your mind

Treat yourself

Be picky