The Best Hotels in Sant' Ambrogio, Florence - 2026 Updated Prices

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Compare popular hotels in Sant' Ambrogio

Property	Property class	Guest rating
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World	5.0 star property	10.0 Exceptional 17 reviews	View
Hotel Regency	5.0 star property	9.4 Exceptional 447 reviews	View
Hotel Cardinal Of Florence	3.0 star property	8.6 Excellent 334 reviews	View
Hotel Villa Liana	3.0 star property	8.6 Excellent 352 reviews	View
J And J Historic House Hotel	5.0 star property	8.6 Excellent 4 reviews	View

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

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Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Uffizi Gallery while you're exploring the neighbourhood.

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San Giovanni

If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.

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Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

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Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

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Top Sant' Ambrogio Hotel Reviews

B&B di Piazza del Duomo

10/10 Excellent

"Clean room, ideal location, friendly welcoming staff"

Villa Tortorelli

10/10 Excellent

"We stayed in Villa Tortorelli for 5 nights. Lovely room overlooking the pool. Bathroom large and very clean. It was so peaceful at night but still only 20 mins walk to Duomo. Breakfast was very good with plenty of choice. Staff are exceptional. Couldn't do enough to make sure our stay was enjoyable."

Hotel Cardinal Of Florence

10/10 Excellent

"Giuseppe checked us in he was incredibly helpful and gave us a map of all the tourist spots to see! There was always water and juice available and the sunrise on the rooftop was so worth it! Although there is a tall climb to the get to the room if you are able to, it’s worth it!! We loved our stay and highly reccomend! "

Guest house Biffi Simone

10/10 Excellent

"Fabulous location at an affordable (for Florence) price. Air conditioning available as well as microwave etc in communal lobby area. Room and bathroom a good size. There will be a little bit of noise from outside but this is what happens in a good location, and I found it generally very quiet at night. There is a bit of noise from adjoining rooms if your neighbour likes to sing in the bathroom...but otherwise it's well laid out to prevent much noise transfer. Communication was excellent and host could not have been more hospitable and helpful when it came to check in etc. Would definitely recommend."

Frequently asked questions

What's it like in Sant' Ambrogio?

Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Piazza Massimo D'Azeglio and Jewish Museum as part of your Sant' Ambrogio travel plans.

What's a favourite hotel to stay in Sant' Ambrogio?

Based on our traveller data, Hotel Bodoni is one of the top choices for your stay in Sant' Ambrogio. This hotel is a short 8-minute walk from Cathedral of Santa Maria del Fiore, and it offers free breakfast and a bar. Other good options for your stay in the neighbourhood include Hotel Bavaria and Hotel Regency.

How many hotels can I expect to find in Sant' Ambrogio?

If you're searching for places to stay in Florence, Expedia has something to meet your needs with 517 Sant' Ambrogio hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.

What is there to do around this Florence neighbourhood?

Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Piazza Massimo D'Azeglio and Jewish Museum are also a couple of places to visit in the neighbourhood. Don't miss favourite places to visit in the surrounding area, such as Cathedral of Santa Maria del Fiore, Uffizi Gallery and Piazza di Santa Maria Novella. When you're sightseeing in Florence, FiesoleBike Day Tours and Mercato di Sant'Ambrogio are also worth a stop.

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Our top choices for Sant' Ambrogio hotels

Boheme

Mamo Florence - Fiesolana & Fiona Apartments

Hotel Regency

Tosca

Hotel Bavaria

B&B di Piazza del Duomo

Appartamento Puccini

Residenza D'Epoca Sant'Egidio

Wine Apartments Florence Grechetto

PALAZZO TESTA - LOCAZIONE TURISTICA

Hotel Bodoni

Mamo Florence - Gm Apartment

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

Wine Apartments Florence Sagrantino

Alfieri9

Hotel Villa Liana

Santacroce Suite

Vista Lumina by MMega

Residenza d'Epoca Borgo Albizi

Villa Tortorelli

Compare popular hotels in Sant' Ambrogio

Where to stay in Sant' Ambrogio

Historic Centre of Florence

Duomo

San Giovanni

Santa Maria Novella

Santa Croce

Top Sant' Ambrogio Hotel Reviews

B&B di Piazza del Duomo

Frequently asked questions

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