The Best Hotels in Sant' Ambrogio, Florence - 2026 Updated Prices

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Compare popular hotels in Sant' Ambrogio

Property	Property class	Guest rating
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World	5.0 star property	10.0 Exceptional 20 reviews	View
Alfieri9	3.0 star property	9.6 Exceptional 167 reviews	View
Hotel Regency	5.0 star property	9.4 Exceptional 451 reviews	View
Hotel Villa Liana	3.0 star property	8.6 Excellent 354 reviews	View
J And J Historic House Hotel	5.0 star property	8.6 Excellent 4 reviews	View

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

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Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Piazza della Signoria while you're exploring the neighbourhood.

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San Giovanni

If you're spending some time in San Giovanni, Piazza della Signoria and Uffizi Gallery are top sights worth seeing.

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Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

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Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

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Top Sant' Ambrogio Hotel Reviews

Dimora del Cardinale - Residenza d'epoca

10/10 Excellent

"Staff were amazing. Beds were very comfortable , air conditioner worked great. Location was perfect, safe, quaint and easy to walk to all attractions within minutes. Would definitely stay again."

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

10/10 Excellent

"This property is stunning. Our room was comfortable, clean, and exquisitely designed. Our only complaint is that there is not food available midday. They have a room service menu, but they don’t actually have the items available outside of dinner time (even though the menu says otherwise). It was only an issue when we first arrived very tired, as there are plenty of food options close to the hotel."

Hotel Bodoni

8/10 Good

"We had a wonderful stay at Hotel Boccaccio in Florence. The room was comfortable, clean, and well-maintained, and the staff was friendly and helpful throughout our visit. The location was excellent for exploring the city, and overall we were very happy with our experience. The only challenge was arriving by car. The hotel does not have on-site parking, and there is not really a designated area to temporarily stop and unload luggage. As a result, we had to park first and then walk our luggage through the streets of Florence to reach the hotel, which was not ideal after a long drive. Other than that, everything was great, and we would definitely consider staying here again."

Frequently asked questions

What's it like in Sant' Ambrogio?

Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Jewish Museum and Piazza Massimo D'Azeglio as part of your Sant' Ambrogio travel plans.

What's a favourite hotel to stay in Sant' Ambrogio?

Based on our traveller data, Hotel Regency is one of the top choices for your stay in Sant' Ambrogio. This hotel is a short 15-minute walk from Cathedral of Santa Maria del Fiore, and it offers free breakfast and a restaurant. Other good options for your stay in the neighbourhood include Hotel Bavaria and Hotel Bodoni.

How many hotels can I expect to find in Sant' Ambrogio?

If you're searching for places to stay in Florence, Expedia has something to meet your needs with 531 Sant' Ambrogio hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.

What is there to do around this Florence neighbourhood?

Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Jewish Museum and Piazza Massimo D'Azeglio are also a couple of places to visit in the neighbourhood. Don't miss favourite places to visit in the surrounding area, such as Cathedral of Santa Maria del Fiore, Piazza della Signoria and Uffizi Gallery. When you're sightseeing in Florence, Piazza di Santa Maria Novella and FiesoleBike Day Tours are also worth a stop.

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Our top choices for Sant' Ambrogio hotels

Mamo Florence - Dante & Virgilio Apartments

Boheme

Hotel Bavaria

B&B di Piazza del Duomo

PALAZZO TESTA - LOCAZIONE TURISTICA

Residenza D'Epoca Sant'Egidio

Tosca

Dimora del Cardinale - Residenza d'epoca

Locanda Orchidea - B&B

Hotel Bodoni

Mamo Florence - Fiesolana & Fiona Apartments

Wine Apartments Florence Sagrantino

Hotel Cardinal Of Florence

Iris Apartments by Mmega

Guest house Biffi Simone

Vista Lumina by MMega

Appartamento Puccini

Santacroce Suite

Mamo Florence - Mattonaia Apartment

Blue Santa Croce by MMega

Compare popular hotels in Sant' Ambrogio

Where to stay in Sant' Ambrogio

Historic Centre of Florence

Duomo

San Giovanni

Santa Maria Novella

Santa Croce

Top Sant' Ambrogio Hotel Reviews

Dimora del Cardinale - Residenza d'epoca

Frequently asked questions

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