TOP Family-Friendly Hotels in Mission District, CA for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Mission District family-friendly hotels

A wooden deck with a table set for two, featuring a plate of food and a cup of coffee.

1. Noe's Nest Bed and Breakfast

Mission District

₹28,779 total

includes taxes & fees

8 Dec - 9 Dec

A hotel room with two beds, a desk, a chair, a TV, and a large window with a city view.

2. Holiday Inn Golden Gateway by IHG

Downtown San Francisco

₹13,153 total

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with large windows, a seating area with a sofa and chairs, and a counter with a coffee station.

3. LUMA Hotel San Francisco

Downtown San Francisco

₹23,907 total

includes taxes & fees

23 Nov - 24 Nov

A tall hotel with a modern design, a prominent entrance, and a view of the city skyline.

4. Hilton San Francisco Financial District

Downtown San Francisco

Delightful ocean-view escape with kid-friendly entertainment, cots, and premium TV with Netflix just minutes from family beaches.

₹10,394 total

includes taxes & fees

29 Nov - 30 Nov

A hotel with a modern design, featuring a prominent 'PARC 55' sign, multiple floors, and a corner location with a visible street view.

5. Parc 55 San Francisco - A Hilton Hotel

Union Square

Family adventures await in stylish San Francisco hotel with city views, gaming consoles, and a large fitness centre.

₹16,224 total

includes taxes & fees

29 Nov - 30 Nov

A modern hotel lobby with a seating area, a bar, and large windows.

6. Hotel Riu Plaza Fisherman's Wharf

Fisherman's Wharf

Family escape with splash-worthy pool, fireside gatherings, and easy walks to Pier 39's seaside adventures awaits.

₹16,984 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, nightstands, lamps, and a decorative wall panel.

7. Hyatt Regency San Francisco

Downtown San Francisco

Family-friendly San Francisco retreat with easy access to Golden Gate Park and luxurious accommodation for all ages.

₹23,012 total

includes taxes & fees

13 Nov - 14 Nov

An indoor swimming pool with multiple lounge chairs and a high ceiling with skylights.

8. Hotel Nikko San Francisco

Union Square

Family holidays thrive at this luxurious urban retreat with indoor pool and rooftop terrace near Union Square.

₹23,954 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a bed, a sofa, a small table, a chair, and a desk.

9. Symphony Inn

Western Addition

₹14,020 total

includes taxes & fees

12 Nov - 13 Nov

A hotel room with a large bed, a desk with a chair, a TV, and a view of the city.

10. Comfort Inn by the Bay

Cow Hollow

Family-friendly comfort near iconic San Francisco sites with free breakfast and premium TV channels.

₹11,407 total

includes taxes & fees

30 Nov - 1 Dec

View all properties

Compare popular hotels in Mission District

Property	Property class	Guest rating
Noe's Nest Bed and Breakfast	3.5 star property	9.4 Exceptional 136 reviews	View
LUMA Hotel San Francisco	4.0 star property	9.6 Exceptional 2,677 reviews	View
Holiday Inn Golden Gateway by IHG	3.5 star property	9.0 Wonderful 6,469 reviews	View
Hyatt Regency San Francisco	4.0 star property	9.2 Wonderful 2,565 reviews	View
Hilton San Francisco Financial District	4.0 star property	8.8 Excellent 3,414 reviews	View

Top Mission District Hotel Reviews

Noe's Nest Bed and Breakfast

Mission District

10/10 Excellent

Annabel

A marble-floored hallway leading to a living area with a sofa and a fireplace.

Galleria Park Hotel

Downtown San Francisco

10/10 Excellent

Elwira

A hotel room with two beds, a desk, a chair, a TV, and a bathroom visible through an open door.

La Casa Inn

Marina District

10/10 Excellent

Housekeeping staff were amazing, super friendly and so helpful, rooms absolutely spotless, huge shower room in Rm 202 2nd floor, right next to elevator. Fab room as we had loads of cases & bags. Prime location, we actually walked to Ghiardelli square and Fisherman's Wharf from there, used Waymos quite a lot they were super fun 😁 The only con I have is for some unkown reason in San Francisco, folks like to roar about on motorbikes from about 7pm-12am ish and from our room, quite loud,...

Catherine Patricia

A room with a large window overlooking a harbor, featuring a sailboat and a building with multiple stories.

Argonaut Hotel

Fisherman's Wharf

10/10 Excellent

We were a bit worried when we arrived that the area outside the hotel was crazy busy and full of loud cars, bikes and music… but we had read a top tip to request a courtyard room and so actually our room was super quiet and relaxing and a nice break from the chaos of fisherman’s wharf. Restaurant breakfast was delicious but there’s also a latam coffee shop on the corner of the block directly behind the hotel who do amazing pastries. The hotel is perfectly located for the tram stop (get there...

Emma

A hotel with a 'NO RESORT FEES' sign, a restaurant, and a cigar store.

Marines Memorial Club & Hotel

Union Square

10/10 Excellent

Donna

Hotel Nikko San Francisco

Union Square

10/10 Excellent

Barbara

A hotel room with a large bed, a desk, a chair, and a view of a cityscape.

Hotel Caza Fisherman´s Wharf

Fisherman's Wharf

10/10 Excellent

First time stay at this hotel. Great location. Great public transport almost on doorstep. Great customer service at front desk. Al at the bar was excellent and gave some great tips on getting about. We were in Room 504, and had a view of Alcatraz and the Bay Bridge. We asked for a mini fridge and coffee making facilities, and by the time we got back from our trip for dinner, they were set up in our room for us. Bed was very comfortable. Will definitely stay here again.

Craig

Parc 55 San Francisco - A Hilton Hotel

Union Square

10/10 Excellent

Bronwen

A grand entrance with a staircase leading to a lobby, flanked by ornate columns and potted plants.

Hotel Majestic

Western Addition

10/10 Excellent

Catherine

A rooftop terrace with a table and chairs, a potted plant, and a view of tall buildings.

Club Quarters Hotel Embarcadero, San Francisco

Downtown San Francisco

10/10 Excellent

NEIL

Frequently Asked Questions

What's Mission District like for family-friendly holidays?

The destination of Mission District is a great choice if you've been thinking about a holiday with your children. The entertainment, museums and festivals are just a few things that make this an attractive holiday destination for families. Take to the air and fly into San Francisco International Airport (SFO), which is located 10 mi (16.1 km) from the centre of Mission District.

What's there to see and do with your family in Mission District?

While you and your family are visiting Mission District, you may want to explore some child-friendly attractions such as SOMA Pilipinas and The Chapel. Make sure that you have plenty of time to take in activities in the area such as Chase Center, Oracle Park and Pier 39.

Explore a world of travel with Expedia

Flights to San Francisco
Standard Link for Flights to San Francisco

Search Family-Friendly Hotels in Mission District

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Mission District family-friendly hotels

1. Noe's Nest Bed and Breakfast

2. Holiday Inn Golden Gateway by IHG

3. LUMA Hotel San Francisco

4. Hilton San Francisco Financial District

5. Parc 55 San Francisco - A Hilton Hotel

6. Hotel Riu Plaza Fisherman's Wharf

7. Hyatt Regency San Francisco

8. Hotel Nikko San Francisco

9. Symphony Inn

10. Comfort Inn by the Bay

Compare popular hotels in Mission District

Top Mission District Hotel Reviews

Noe's Nest Bed and Breakfast

10/10 Excellent

Frequently Asked Questions

What's Mission District like for family-friendly holidays?

What's there to see and do with your family in Mission District?

Explore a world of travel with Expedia