The Best Hotels Closest to UCSF Mission Bay in San Francisco - 2026 Updated Prices

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Our top choices for UCSF Mission Bay hotels

A spacious lobby with large windows, a seating area with a sofa and chairs, and a counter with a coffee station.

A bar area with a long counter, multiple seating options, and a city view.

A modern reception area with a large screen displaying a desert landscape, wooden reception desk, comfortable seating, and a large window offering a view.

A hotel room with a large bed, a desk, a chair, and a view of the city through large windows.

1. LUMA Hotel San Francisco

0.7 km from UCSF Mission Bay

Heather

₹24,214

₹28,500 total

includes taxes & fees

23 Oct - 24 Oct

A dining table with plates of food, two wine glasses, and cutlery, set against a cityscape view.

A banquet hall with a central stage, chandeliers, and rows of tables set for a formal event.

A swimming pool with lane dividers, a sign for the Marines' Memorial Association, and a lifeguard chair.

A grand lobby with a chandelier, a reception desk, and a bell in the center.

2. Marines Memorial Club & Hotel

2.7 km from UCSF Mission Bay

Audrey

₹16,340

₹19,200 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor seating area with wicker furniture and a fire feature, adjacent to a bar and dining area with modern decor.

A modern bar area with multiple seating options, a bar counter, and a television screen.

A modern lounge area with sofas, armchairs, and tables.

A modern dining area with a large rectangular table surrounded by upholstered chairs, a decorative chandelier, and a view of the outdoors through large windows.

3. Hyatt Place San Francisco Downtown

1.1 km from UCSF Mission Bay

MELISSA

₹18,517

₹21,793 total

includes taxes & fees

8 Nov - 9 Nov

A rooftop terrace with tables and potted plants, overlooking a cityscape with a prominent tower and a bridge.

A modern room with a large window offering a city view, a red chair, a white table, and a bowl of apples.

A modern living room with a sofa, a coffee table, and a view of a cityscape and bridge.

A hotel room with a large bed, a round table with a bowl of greenery, a desk with books, a framed artwork, and a view of a bridge and cityscape.

4. Four Seasons Hotel San Francisco at Embarcadero

Financial District, 2.7 km from UCSF Mission Bay

Seo Yong

₹42,375

₹49,873 total

includes taxes & fees

13 Nov - 14 Nov

A marble-floored hallway leading to a living area with a sofa and a fireplace.

A hotel with a brick facade, a red awning, and a sign for 'Galleria Park Hotel'.

A bar cart with gin bottles and glasses on a carpeted floor.

A spacious, elegantly furnished living area with a high ceiling, a fireplace, and a large abstract painting.

5. Galleria Park Hotel

Financial District, 2.5 km from UCSF Mission Bay

Joseph

₹14,178

₹20,598 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with multiple lounge chairs and a high ceiling with skylights.

A spacious lobby with a grand staircase, seating areas, and a piano.

A multi-story hotel with a classic facade, large windows, and a prominent entrance.

A modern restaurant with a central bar area, seating arrangements, and large windows offering a view of greenery.

6. Hotel Nikko San Francisco

Union Square, 2.4 km from UCSF Mission Bay

Ryan

₹17,676

₹25,171 total

includes taxes & fees

30 Oct - 31 Oct

The exterior of an Orchard Hotel with a prominent entrance, large windows, and a well-lit facade.

A modern kitchen with a bar area, wooden cabinets, and a chandelier.

A reception area with a wooden reception desk, a receptionist, a statue, and a potted plant.

A restaurant with multiple tables, each set with white tablecloths, plates, and cutlery.

7. Orchard Garden Hotel

Chinatown, 2.7 km from UCSF Mission Bay

Ashlee

₹13,682

₹16,314 total

includes taxes & fees

13 Nov - 14 Nov

A modern building facade with vertical wooden slats, a glass entrance, and a sign reading "La Société Bar & Cafe".

A modern bar area with multiple seating options, a large pillar, and a television screen.

A hotel room with a large bed, a desk, a chair, a small table with a plant, and a view of a cityscape at dusk.

A modern living room with a sofa, coffee table, and ottoman, a kitchen area with wooden cabinets and a flat-screen TV, and a large window offering a city view.

8. Hyatt Regency San Francisco Downtown SOMA

South of Market, 2.2 km from UCSF Mission Bay

Julio

₹16,048

₹22,676 total

includes taxes & fees

30 Oct - 31 Oct

A buffet area with a variety of food items and condiments.

A modern building with a glass facade, large windows, and a prominent entrance with illuminated signage.

A modern hotel room with a large window offering a city view, a neatly made bed, and a hanging light fixture.

A modern bar area with a colorful ceiling, wooden stools, and a bar counter.

9. citizenM San Francisco Union Square

Union Square, 2.3 km from UCSF Mission Bay

Patrice

₹12,344

₹14,529 total

includes taxes & fees

30 Oct - 31 Oct

A restaurant interior with wooden tables and booths, a tiled pillar, and a unique ceiling design.

A hotel room with a bed, a desk, a chair, a sofa, a TV, and a large mirror.

A conference room with a long table, chairs, a potted plant, a tablet, and a TV on the wall.

A bar area with stools, a red door, and a wall with a fruit pattern.

10. Hotel G San Francisco

2.6 km from UCSF Mission Bay

matthew

₹12,748

₹18,804 total

includes taxes & fees

23 Oct - 24 Oct

A modern hotel with a sleek exterior and a parked sports car in front.

A rooftop bar with outdoor seating, a view of the cityscape, and a clock tower in the background.

A modern lobby with a curved sofa, round tables, a reception desk, and a large blue wall feature.

A hotel reception desk with a sign reading "HOTEL VIA", a vase with white flowers, a glass of champagne, and a small plate with a chocolate dessert.

11. Hotel VIA

1.2 km from UCSF Mission Bay

Gabriela

₹18,716

₹22,028 total

includes taxes & fees

6 Nov - 7 Nov

A grand lobby with high ceilings, chandeliers, and a fireplace.

A person with a suitcase at the entrance of a building with a blue wall and a decorative door.

A grand lobby with a checkered floor, a blue sofa, and a chandelier.

A hallway with a Christmas tree and nutcracker statues.

12. The Marker Union Square San Francisco

2.6 km from UCSF Mission Bay

Samantha

₹15,480

₹18,219 total

includes taxes & fees

7 Nov - 8 Nov

A modern hotel with a glass facade, a covered entrance, and a sign indicating it is a Marriott hotel.

A modern reception area with a round mirror, seating, and a wooden panel wall.

A nighttime cityscape through a window, featuring illuminated skyscrapers and a view of the urban landscape.

A modern lounge area with a large mirror, comfortable seating, a coffee table with a tray, and a view of the cityscape through large windows.

13. The St. Regis San Francisco

South of Market, 2.1 km from UCSF Mission Bay

Christopher

₹43,965

₹56,086 total

includes taxes & fees

30 Oct - 31 Oct

A rooftop terrace with outdoor seating, a view of the city skyline, and modern buildings in the background.

A modern building with a unique angular design, surrounded by other high-rise structures.

A modern hotel room with a sofa, armchair, coffee table, and a desk with a lamp. There is a bed with a white headboard and a view of the city through large windows.

A modern living room with a sofa, coffee table, and television. There are chairs, a bookshelf, and a large window with a view of buildings.

14. Four Seasons Hotel San Francisco

South of Market, 2.3 km from UCSF Mission Bay

Sun Ding

₹38,339

₹50,711 total

includes taxes & fees

30 Oct - 31 Oct

A hotel room with a large window, a sofa, two armchairs, a coffee table, a lamp, and a TV.

A modern building with a glass facade and a prominent entrance.

An indoor swimming pool with clear water, a ceiling with a blue marble pattern, and a window with a view of the outside.

A hotel room with a large window offering a city view, a bed, a desk with a lamp, and a chair.

15. InterContinental San Francisco by IHG

South of Market, 1.8 km from UCSF Mission Bay

Jose

₹17,662

₹26,152 total

includes taxes & fees

23 Oct - 24 Oct

A modern living room with a large window overlooking a bridge, a flat-screen TV, a clock, and a brown leather sofa.

A group of people dining at a restaurant with a table set for a meal, including a bottle of wine and various dishes.

A room with large windows overlooking a bridge and a body of water.

A cozy hotel lobby with a fireplace, two tables with teapots, and comfortable seating.

16. Harbor Court Hotel

South of Market, 2.6 km from UCSF Mission Bay

Emily

₹19,229

₹27,214 total

includes taxes & fees

13 Nov - 14 Nov

A lobby with a brown leather sofa, a wooden coffee table with books, a blue staircase, and a wall with a map and text.

A hotel hallway with a patterned carpet, wooden benches, and a laundry sign.

A cozy living room with a patterned carpet, a blue sofa, a brown leather couch, and a guitar leaning against the wall.

A reception desk with wooden panels, two pendant lights, and a bulletin board with various notices.

17. HI San Francisco Downtown Hostel

Union Square, 2.5 km from UCSF Mission Bay

Florence

₹6,751

₹7,862 total

includes taxes & fees

16 Nov - 17 Nov

A grand hall with a high arched ceiling and chandeliers, featuring multiple dining tables and chairs arranged for service.

A grand lobby with a chandelier, large arched windows, and a central floral arrangement.

A grand lobby with marble columns, a chandelier, and seating areas.

A grand lobby with marble columns, a chandelier, and a spacious seating area.

18. Palace Hotel, a Luxury Collection Hotel, San Francisco

Financial District, 2.3 km from UCSF Mission Bay

NELSON PEREZ

₹28,972

₹38,569 total

includes taxes & fees

30 Oct - 31 Oct

A spacious lobby with a staircase, comfortable seating areas, and large windows offering views of the city.

A spacious lobby with a modern bar area, seating arrangements, and a geometric wall design.

A modern building with a prominent entrance and a sign that reads "THE CLANCY".

A modern cafe with a large window, white walls, and a variety of seating options including tables and a bench.

19. The Clancy, Autograph Collection by Marriott

South Park, 1.9 km from UCSF Mission Bay

Samantha

₹16,691

₹23,911 total

includes taxes & fees

30 Oct - 31 Oct

A modern hotel room with a grey sofa, a dining table, a TV, and a large window with curtains.

A spacious hotel lobby with large windows, wooden beams, and a central bar area.

A spacious room with large windows, two armchairs, a small table with books, and a lamp.

A hotel room with a bed, a bathroom with a sink and mirror, and a view of the outside through the window.

20. The Clift Royal Sonesta San Francisco

2.6 km from UCSF Mission Bay

Randall Gray

₹18,897

₹25,944 total

includes taxes & fees

6 Nov - 7 Nov

View all properties

Compare popular hotels close to UCSF Mission Bay

Property	Property class	Guest rating
LUMA Hotel San Francisco	9.6 Exceptional 2,638 reviews	View
Marines Memorial Club & Hotel	9.6 Exceptional 236 reviews	View
Four Seasons Hotel San Francisco at Embarcadero	9.6 Exceptional 1,002 reviews	View
Hyatt Place San Francisco Downtown	9.4 Exceptional 2,366 reviews	View
Galleria Park Hotel	9.6 Exceptional 1,058 reviews	View

Top UCSF Mission Bay Hotel Reviews

Holiday Inn Golden Gateway by IHG

10/10 Excellent

"Beautiful view, worth the money, and excellent location"

Parc 55 San Francisco - A Hilton Hotel

10/10 Excellent

"My family and I love staying at this hotel. It's clean, staff is friendly, and the location is great. Thanks to Carlton and Ryan for always making me feel welcomed."

LUMA Hotel San Francisco

10/10 Excellent

"The Luma hotel is a very nice hotel, the room was really nice and clean. The staff was professional, nice and friendly. I enjoyed my stay and the staff/GM did a great job with setting up a positive environment the morning of the WNBA Finals."

Hilton San Francisco Union Square

10/10 Excellent

"The hotel is very huge.there are many guests at the bar in the hall.we only aren't satisified without free bottle water in the room."

Handlery Union Square Hotel

10/10 Excellent

"good"

Hilton San Francisco Financial District

8/10 Good

"Good"

Chancellor Hotel on Union Square

10/10 Excellent

"Clean room. Helpful staff. Given that it’s a historical hotel, expected that the rooms are a little tighter. But good location, there’s convenient offsite parking nearby if you have a car or there’s good access to public transit options. Would recommend!"

Frequently asked questions

What's the area like around UCSF Mission Bay?

UCSF Mission Bay is located in a vibrant area of San Francisco known for its top museums and stunning architecture. If you're looking for a convenient place to stay, take a look at the 41 hotels and other accommodation options you'll find within a mile.

What's the best place to stay near UCSF Mission Bay?

LUMA Hotel San Francisco is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and a fitness centre. It's located just a short 0.4 mi (0.7 km) from UCSF Mission Bay. Another good choice is Hyatt Place San Francisco Downtown, located just 0.7 mi (1.1 km) away.

How many hotels will I be able to find close to UCSF Mission Bay?

Expedia has 41 hotels and other accommodation options within a mile from UCSF Mission Bay.

If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund?

Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Add dates, click "Search", then use the filter option "fully refundable" to view top deals close to UCSF Mission Bay.

What can I see and do near UCSF Mission Bay?

Study the collections at San Francisco Museum of Modern Art, Contemporary Jewish Museum or Asian Art Museum of San Francisco. Sights like San Francisco Mint, Palace Hotel and 450 Sutter Building are landmarks to visit in the area. You can check out the local talent at The Midway, Warfield Theatre and Golden Gate Theatre.

How can I get to UCSF Mission Bay?

With so many choices for transport, seeing all of the area near UCSF Mission Bay is simple. You can access metro transport at Market St & 5th St Stop, Market St & Taylor St Stop and Powell St & Market St Stop. If you're hopping a train into the city, San Francisco Station is the closest station to Downtown San Francisco.

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Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for UCSF Mission Bay hotels

1. LUMA Hotel San Francisco

2. Marines Memorial Club & Hotel

3. Hyatt Place San Francisco Downtown

4. Four Seasons Hotel San Francisco at Embarcadero

5. Galleria Park Hotel

6. Hotel Nikko San Francisco

7. Orchard Garden Hotel

8. Hyatt Regency San Francisco Downtown SOMA

9. citizenM San Francisco Union Square

10. Hotel G San Francisco

11. Hotel VIA

12. The Marker Union Square San Francisco

13. The St. Regis San Francisco

14. Four Seasons Hotel San Francisco

15. InterContinental San Francisco by IHG

16. Harbor Court Hotel

17. HI San Francisco Downtown Hostel

18. Palace Hotel, a Luxury Collection Hotel, San Francisco

19. The Clancy, Autograph Collection by Marriott

20. The Clift Royal Sonesta San Francisco

Compare popular hotels close to UCSF Mission Bay

Top UCSF Mission Bay Hotel Reviews

Holiday Inn Golden Gateway by IHG

Parc 55 San Francisco - A Hilton Hotel

LUMA Hotel San Francisco

Hilton San Francisco Union Square

Handlery Union Square Hotel

Hilton San Francisco Financial District

Chancellor Hotel on Union Square

Frequently asked questions

Explore a world of travel with Expedia

Search Hotels Near UCSF Mission Bay, San Francisco

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for UCSF Mission Bay hotels

1. LUMA Hotel San Francisco

2. Marines Memorial Club & Hotel

3. Hyatt Place San Francisco Downtown

4. Four Seasons Hotel San Francisco at Embarcadero

5. Galleria Park Hotel

6. Hotel Nikko San Francisco

7. Orchard Garden Hotel

8. Hyatt Regency San Francisco Downtown SOMA

9. citizenM San Francisco Union Square

10. Hotel G San Francisco

11. Hotel VIA

12. The Marker Union Square San Francisco

13. The St. Regis San Francisco

14. Four Seasons Hotel San Francisco

15. InterContinental San Francisco by IHG

16. Harbor Court Hotel

17. HI San Francisco Downtown Hostel

18. Palace Hotel, a Luxury Collection Hotel, San Francisco

19. The Clancy, Autograph Collection by Marriott

20. The Clift Royal Sonesta San Francisco

Compare popular hotels close to UCSF Mission Bay

Top UCSF Mission Bay Hotel Reviews

Holiday Inn Golden Gateway by IHG

Parc 55 San Francisco - A Hilton Hotel

LUMA Hotel San Francisco

Hilton San Francisco Union Square

Handlery Union Square Hotel

Hilton San Francisco Financial District

Chancellor Hotel on Union Square

Frequently asked questions

Explore a world of travel with Expedia