The Best Hotels Closest to UCSF Mission Bay in San Francisco - 2026 Updated Prices

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Our top choices for UCSF Mission Bay hotels

1. LUMA Hotel San Francisco

0.7 km from UCSF Mission Bay

Ryan

₹24,407 total

includes taxes & fees

31 Jul - 1 Aug

2. Chancellor Hotel on Union Square

Lower Nob Hill, 2.6 km from UCSF Mission Bay

Devin

₹10,837 total

includes taxes & fees

27 Jul - 28 Jul

3. Hyatt Place San Francisco Downtown

1.1 km from UCSF Mission Bay

Xiaolei

₹22,590 total

includes taxes & fees

23 Jul - 24 Jul

4. Hotel Nikko San Francisco

Union Square, 2.4 km from UCSF Mission Bay

David

₹24,602 total

includes taxes & fees

16 Aug - 17 Aug

5. citizenM San Francisco Union Square

Union Square, 2.3 km from UCSF Mission Bay

Vinay

₹14,731 total

includes taxes & fees

2 Aug - 3 Aug

6. Orchard Garden Hotel

Chinatown, 2.7 km from UCSF Mission Bay

john

₹17,884 total

includes taxes & fees

13 Aug - 14 Aug

7. Galleria Park Hotel

Financial District, 2.5 km from UCSF Mission Bay

IAN R

₹17,881 total

includes taxes & fees

16 Aug - 17 Aug

8. Hotel G San Francisco

Lower Nob Hill, 2.6 km from UCSF Mission Bay

Andrew

₹17,258 total

includes taxes & fees

3 Aug - 4 Aug

9. InterContinental San Francisco by IHG

South of Market, 1.8 km from UCSF Mission Bay

Luis Adolfo

₹26,954 total

includes taxes & fees

2 Aug - 3 Aug

10. The St. Regis San Francisco

South of Market, 2.1 km from UCSF Mission Bay

John

₹56,867 total

includes taxes & fees

14 Aug - 15 Aug

11. Four Seasons Hotel San Francisco

South of Market, 2.3 km from UCSF Mission Bay

Klaus

₹51,084 total

includes taxes & fees

16 Aug - 17 Aug

12. The Marker Union Square San Francisco

Theater District, 2.6 km from UCSF Mission Bay

₹18,288 total

includes taxes & fees

10 Aug - 11 Aug

13. Hotel VIA

1.2 km from UCSF Mission Bay

Michael

₹25,996 total

includes taxes & fees

31 Jul - 1 Aug

55-inch TV with digital channels, pay films

14. The Clift Royal Sonesta San Francisco

Theater District, 2.6 km from UCSF Mission Bay

Karla

₹25,217 total

includes taxes & fees

1 Aug - 2 Aug

15. Palace Hotel, a Luxury Collection Hotel, San Francisco

Financial District, 2.3 km from UCSF Mission Bay

Michael

₹43,024 total

includes taxes & fees

31 Jul - 1 Aug

Suite (Skyline Waterfront Penthouse) | View from room

16. Harbor Court Hotel

South of Market, 2.6 km from UCSF Mission Bay

Frederick

₹21,115 total

includes taxes & fees

16 Aug - 17 Aug

17. Taj Campton Place

Union Square, 2.6 km from UCSF Mission Bay

Javier

₹31,732 total

includes taxes & fees

2 Aug - 3 Aug

Premium bedding, pillow-top beds, in-room safe, desk

18. Inn At Union Square

Lower Nob Hill, 2.6 km from UCSF Mission Bay

Vincent

₹12,771 total

includes taxes & fees

20 Aug - 21 Aug

19. The Clancy, Autograph Collection by Marriott

South Park, 1.9 km from UCSF Mission Bay

Sandy

₹22,990 total

includes taxes & fees

14 Aug - 15 Aug

20. HI San Francisco Downtown Hostel

Union Square, 2.5 km from UCSF Mission Bay

Dong

₹9,988 total

includes taxes & fees

2 Aug - 3 Aug

View all properties

Compare popular hotels close to UCSF Mission Bay

Property	Property class	Guest rating
LUMA Hotel San Francisco	4.0 star property	9.6 Exceptional 2,556 reviews	View
Chancellor Hotel on Union Square	3.5 star property	9.2 Wonderful 3,352 reviews	View
Hyatt Place San Francisco Downtown	3.0 star property	9.4 Exceptional 2,241 reviews	View
Hotel Nikko San Francisco	4.5 star property	9.4 Exceptional 2,998 reviews	View
citizenM San Francisco Union Square	4.0 star property	9.4 Exceptional 1,464 reviews	View

Top UCSF Mission Bay Hotel Reviews

Holiday Inn Golden Gateway by IHG

10/10 Excellent

"Our stay at the Golden Gate Hotel made our San Francisco trip even more memorable. From the moment we arrived, we felt welcomed and comfortable. The hotel’s historic charm gave us a true San Francisco experience, and it was the perfect home base after our days of exploring the city. The location was one of our favorite things about the hotel. We loved being in Nob Hill, a beautiful and quieter area away from some of the busier, more touristy parts of San Francisco, while still being close enough to easily enjoy everything the city has to offer. We were able to walk around the neighborhood, ride the famous cable cars, visit Alcatraz, explore Fisherman’s Wharf, and see so many of the iconic sights we came to experience. After full days of adventure, it was nice to return to a peaceful and cozy hotel with so much character. The historic details and welcoming atmosphere made it feel like we were staying somewhere special, not just another hotel. The staff was kind and helpful, adding to the personal feel of our stay. San Francisco was a trip we will always remember, and the Golden Gate Hotel was the perfect place to experience the city. I would absolutely recommend it to anyone looking for a charming, unique, and well-located hotel with a true San Francisco feel."

Chancellor Hotel on Union Square

10/10 Excellent

"Loved the old school-hotel vibe. The free cookies out front elevated the check-in experience right off the bat. I wish I would have taken advantage of the pillow ordering service, the default pillows and bed were amazing regardless. The bath salts and rubber ducky in the bathroom was an excellent touch. Make sure to take your ducky with you to remember your trip and stay (it's meant to be taken as a souvenir, we checked!). Would book again"

Hyatt Regency San Francisco Downtown SOMA

10/10 Excellent

"The staff, location and room service were excellent. Walkers would enjoy this location because shopping and dining are all within walking distance. Not too far from the Golden gate bridge and the airport. Highly recommended. There is only 1 restaurant in the hotel and closes early so be aware!"

Frequently asked questions

What's the area like around UCSF Mission Bay?

UCSF Mission Bay is located in a vibrant area of San Francisco known for its top museums and stunning architecture. If you're looking for a convenient place to stay, take a look at the 35 hotels and other accommodation options you'll find within a mile.

What's the best place to stay near UCSF Mission Bay?

LUMA Hotel San Francisco is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and a fitness centre. It's located just a short 0.4 mi (0.7 km) from UCSF Mission Bay. Another good choice is Hyatt Place San Francisco Downtown, located just 0.7 mi (1.1 km) away.

How many hotels will I be able to find close to UCSF Mission Bay?

Expedia has 35 hotels and other accommodation options within a mile from UCSF Mission Bay.

If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund?

Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Add dates, click "Search", then use the filter option "fully refundable" to view top deals close to UCSF Mission Bay.

What can I see and do near UCSF Mission Bay?

Study the collections at San Francisco Museum of Modern Art, Asian Art Museum of San Francisco or Market Street Railway Museum. Sights like Alcatraz Island, San Francisco Mint and 450 Sutter Building are landmarks to visit in the area. You can check out the local talent at The Midway, Warfield Theatre and Golden Gate Theatre.

How can I get to UCSF Mission Bay?

With so many choices for transport, seeing all of the area near UCSF Mission Bay is simple. You can access metro transport at Market St & 5th St Stop, Market St & Taylor St Stop and Powell St & Market St Stop. If you're hopping a train into the city, San Francisco Station is the closest station to Downtown San Francisco.

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Our top choices for UCSF Mission Bay hotels

1. LUMA Hotel San Francisco

2. Chancellor Hotel on Union Square

3. Hyatt Place San Francisco Downtown

4. Hotel Nikko San Francisco

5. citizenM San Francisco Union Square

6. Orchard Garden Hotel

7. Galleria Park Hotel

8. Hotel G San Francisco

9. InterContinental San Francisco by IHG

10. The St. Regis San Francisco

11. Four Seasons Hotel San Francisco

12. The Marker Union Square San Francisco

13. Hotel VIA

14. The Clift Royal Sonesta San Francisco

15. Palace Hotel, a Luxury Collection Hotel, San Francisco

16. Harbor Court Hotel

17. Taj Campton Place

18. Inn At Union Square

19. The Clancy, Autograph Collection by Marriott

20. HI San Francisco Downtown Hostel

Compare popular hotels close to UCSF Mission Bay

Top UCSF Mission Bay Hotel Reviews

Holiday Inn Golden Gateway by IHG

Frequently asked questions

Explore a world of travel with Expedia