₹21,428 Cheap American Airlines flights from Raleigh to San Diego (RDU→SAN)

Landing cheap one-way American Airlines flights from RDU to SAN from ₹21,428 on Expedia is a breeze — just filter by "Price (lowest to highest)." Or check out our affordable round-trip fares ₹36,751 for your next exciting holiday.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego are typically more affordable in the quieter months of January and November. Whether you're after a one-way or round-trip ticket, you could land a better deal then.

To figure out if there's a direct route from RDU to SAN with American Airlines or another carrier, check the "Nonstop" box when looking for flights.

Take an American Airlines flight from Raleigh - Durham Intl. Airport (RDU) to San Diego, and you're most likely to touch down at San Diego Intl. Airport (SAN). This is the airline's main hub in this city.

Depending on your fare type, a fee is typically charged if you cancel or change your flight more than 24 hours after it has been confirmed. To find flexible fares, select our "No cancel fee" or "Changes included" filter when you search for flights. For more information on cancelling or modifying your reservation, visit "Trips," select your flight and tick "Manage Booking."