TOP Luxury Hotels in St. Charles, MO for 2026

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Our top choices for St. Charles luxury hotels

An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.

1. Ameristar Casino Resort and Spa

St. Charles

Indulge in lavish comfort at this St. Charles retreat featuring a full-service spa, seasonal pool, and 6 exceptional restaurants.

₹19,058 total

includes taxes & fees

30 Nov - 1 Dec

An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.

2. The Ritz-Carlton, St. Louis

Clayton

Ritz-Carlton elegance defines this St. Louis retreat with indulgent spa services and dining excellence.

₹60,273 total

includes taxes & fees

27 Nov - 28 Nov

A large, modern hotel building with a sign reading "DOUBLETREE BY HILTON." It features a grid of windows and a flat roof.

3. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

Chesterfield hotel offers plush comforts with indoor tennis courts, dual pools, and premium bedding.

₹12,143 total

includes taxes & fees

28 Nov - 29 Nov

A modern hotel lobby with a glass facade, seating area, and a staircase.

4. Four Seasons Hotel St Louis

Downtown St. Louis

Lavish riverside luxury awaits at the Four Seasons St. Louis with spa indulgences and poolside bliss.

₹41,083 total

includes taxes & fees

15 Nov - 16 Nov

A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

5. Drury Plaza Hotel St. Louis Brentwood

Brentwood

₹13,630 total

includes taxes & fees

13 Dec - 14 Dec

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

6. The Royal Sonesta Chase Park Plaza St. Louis

Central West End

Indulge in historic elegance at this St. Louis gem featuring 3 restaurants, a spectacular pool area, and luxurious rooms near Forest Park.

₹17,568 total

includes taxes & fees

22 Nov - 23 Nov

7. 21C Museum Hotel St Louis

Downtown West

Indulge in artistic luxury at this city centre St. Louis hotel with spa services and indoor pool.

₹16,207 total

includes taxes & fees

7 Dec - 8 Dec

A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.

8. The Westin St. Louis

Downtown St. Louis

Opulent city centre retreat with pillowtop beds, soaking tubs, and Italian dining moments from Busch Stadium.

₹13,401 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with ornate ceiling designs, a bar area with stools, and a seating area with tables.

9. St. Louis Union Station Hotel, Curio Collection by Hilton

Downtown West

Experience grandeur in a historic hotel with 7 restaurants, seasonal pool, and concierge services in city centre St. Louis.

₹17,264 total

includes taxes & fees

26 Nov - 27 Nov

A bar area with wooden tables, leather seating, and a bar counter.

10. The Inn at Elijah McLeans

Washington

₹14,020 total

includes taxes & fees

14 Dec - 15 Dec

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Frequently Asked Questions

Are you looking for a luxury hotel for your stay in St. Charles?

During your visit, you might want to enjoy the casinos and shopping which St. Charles is known for.

What's the best luxury hotel in St. Charles?

Ameristar Casino Resort and Spa is a luxury hotel with 6 restaurants and 2 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay.

When can I expect good weather in St. Charles?

Planning for the weather is an important factor for making your trip to St. Charles a success, especially when you're splurging. The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for St. Charles is 1172 mm.

What's there to see and do in St. Charles?

When you're in St. Charles, enjoy exploring the sights and attractions here including Historic Main Street, Katy Trail and Lewis & Clark Boathouse and Nature Center. If you have a little extra time during your trip, you might want to make a stop at St Charles Convention Center and Ameristar Casino St. Charles.

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for St. Charles luxury hotels

1. Ameristar Casino Resort and Spa

2. The Ritz-Carlton, St. Louis

3. DoubleTree by Hilton Hotel St. Louis - Chesterfield

4. Four Seasons Hotel St Louis

5. Drury Plaza Hotel St. Louis Brentwood

6. The Royal Sonesta Chase Park Plaza St. Louis

7. 21C Museum Hotel St Louis

8. The Westin St. Louis

9. St. Louis Union Station Hotel, Curio Collection by Hilton

10. The Inn at Elijah McLeans

Frequently Asked Questions

Are you looking for a luxury hotel for your stay in St. Charles?

What's the best luxury hotel in St. Charles?

When can I expect good weather in St. Charles?

What's there to see and do in St. Charles?

Explore a world of travel with Expedia

Search Luxury Hotels in St. Charles

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for St. Charles luxury hotels

1. Ameristar Casino Resort and Spa

2. The Ritz-Carlton, St. Louis

3. DoubleTree by Hilton Hotel St. Louis - Chesterfield

4. Four Seasons Hotel St Louis

5. Drury Plaza Hotel St. Louis Brentwood

6. The Royal Sonesta Chase Park Plaza St. Louis

7. 21C Museum Hotel St Louis

8. The Westin St. Louis

9. St. Louis Union Station Hotel, Curio Collection by Hilton

10. The Inn at Elijah McLeans

Frequently Asked Questions

Are you looking for a luxury hotel for your stay in St. Charles?

What's the best luxury hotel in St. Charles?

When can I expect good weather in St. Charles?

What's there to see and do in St. Charles?

Explore a world of travel with Expedia