What is Santo Domingo like?

Travellers to Mexico City's Santo Domingo neighbourhood will be sure to enjoy a stay here.

How many hotels will I find in the Santo Domingo area?

Book one of Expedia's 5 hotels and other accommodation options in Santo Domingo and start exploring everything Mexico City has to offer.

If I need to cancel my hotel reservation in Santo Domingo, will I receive a refund?

Yes, most room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to review the best deals available in Santo Domingo.

What are the top things to see and do in Santo Domingo?

Parroquia de San Juan Bautista, Casa del Teatro and Museo Diego Rivera Anahuacalli are just a few of the places to visit in and around Santo Domingo. While you're out sightseeing, Museo de la Ciudad and Hidalgo Plaza are a couple of additional sights to visit in Mexico City.

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Dates

February 2026

March 2026

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Our top choices for Santo Domingo hotels

Camino Real Aeropuerto Mexico

Venustiano Carranza, 14.5 km from Santo Domingo

JOSE LUIS

₹12,857 total

includes taxes & fees

10 Feb - 11 Feb

Breakfast, lunch, dinner served; Mexican cuisine

Zocalo Central & Rooftop Mexico City

Historic Center, 12.1 km from Santo Domingo

John

₹15,565 total

includes taxes & fees

24 Feb - 25 Feb

Indoor pool, open 6 AM to 8 PM, pool loungers

Barceló México Reforma

11.9 km from Santo Domingo

Alejandro

₹14,163 total

includes taxes & fees

18 Feb - 19 Feb

Comfort Room | Desk, laptop workspace, blackout curtains, free WiFi

Hotel Embassy

Roma Norte, 10.5 km from Santo Domingo

Shay

₹4,329 total

includes taxes & fees

2 Feb - 3 Feb

Hotel Juarez

Historic Center, 12.2 km from Santo Domingo

Catalina

₹3,575 total

includes taxes & fees

27 Feb - 28 Feb

Hotel Catedral

Historic Center, 12.4 km from Santo Domingo

Olga

₹22,826 total

includes taxes & fees

31 Jan - 1 Feb

Hotel Punto MX

Historic Center, 11.7 km from Santo Domingo

Jesse

₹5,512 total

includes taxes & fees

2 Feb - 3 Feb

Historico Central Hotel

Historic Center, 12 km from Santo Domingo

Susan

₹14,573 total

includes taxes & fees

23 Feb - 24 Feb

Fiesta Inn Ciudad de Mexico Aeropuerto

Venustiano Carranza, 14.3 km from Santo Domingo

Jorge

₹12,242 total

includes taxes & fees

6 Feb - 7 Feb

Hotel Principal

Historic Center, 11.9 km from Santo Domingo

Claudia

₹5,619 total

includes taxes & fees

28 Jan - 29 Jan

Casa Decu

Hipódromo, 8.9 km from Santo Domingo

Michal

₹15,735 total

includes taxes & fees

11 Feb - 12 Feb

Eurostars Zona Rosa Suites

Zona Rosa, 10.8 km from Santo Domingo

Gustavo

₹8,193 total

includes taxes & fees

27 Feb - 28 Feb

Hotel PF

Zona Rosa, 10.6 km from Santo Domingo

Toni

₹8,939 total

includes taxes & fees

9 Feb - 10 Feb

Grand Prix-WeEnjoyHotels-Aeropuerto

Granjas México, 10.8 km from Santo Domingo

Sarmad

₹9,472 total

includes taxes & fees

1 Feb - 2 Feb

Club Suite, 1 Bedroom | Premium bedding, minibar, in-room safe, desk

Sheraton Maria Isabel Mexico City Reforma

Colonia Cuauhtémoc, 11 km from Santo Domingo

Ligia

₹15,472 total

includes taxes & fees

27 Feb - 28 Feb

Premier Double Room | Select Comfort beds, in-room safe, individually decorated, desk

KALI Centro Mexico City

Downtown Mexico City, 11.2 km from Santo Domingo

Autumn

Holiday Inn Express Mexico Basilica by IHG

14.7 km from Santo Domingo

Mireya

₹7,792 total

includes taxes & fees

1 Feb - 2 Feb

Courtyard Mexico City Airport

Venustiano Carranza, 14.8 km from Santo Domingo

Mauricio

₹19,670 total

includes taxes & fees

30 Jan - 31 Jan

Fiesta Inn Periferico Sur

Coyoacan, 2.9 km from Santo Domingo

Slawomir

₹8,732 total

includes taxes & fees

14 Feb - 15 Feb

Geneve Ciudad de México

Zona Rosa, 10.7 km from Santo Domingo

Andreas

₹15,822 total

includes taxes & fees

24 Feb - 25 Feb

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Where to stay in Santo Domingo

Find the best Santo Domingo areas for the activities you enjoy most.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

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Polanco

Visit the most diverse section of Mexico City for sophisticated shopping, dining, accommodations and sightseeing.

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La Condesa

Enjoy 20th-century history in these two sections of Mexico City, with interesting art and architecture reflecting European influences.

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Metropolitan Cathedral which includes a church or cathedral, heritage elements and heritage architecture

Historic Center

Consider a visit to Palacio de Bellas Artes and take some time to enjoy the interesting museums during your time in Historic Center. If you want to see more of the city, jump on the metro at Allende Station or Bellas Artes Station.

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Reforma

Consider a visit to Paseo de la Reforma and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

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Top Santo Domingo Hotel Reviews

Camino Real Aeropuerto Mexico

10/10 Excellent

"The room was clean and comfortable but there was a children’s party going on somewhere nearby our room that I could hear loudly. They carried on until nearly 10pm. I was so tired I fell asleep anyway but some may be annoyed."