What is Santo Domingo like?

Travellers to Mexico City's Santo Domingo neighbourhood will be sure to enjoy a stay here.

How many hotels will I find in the Santo Domingo area?

Book one of Expedia's 6 hotels and other accommodation options in Santo Domingo and start exploring everything Mexico City has to offer.

If I need to cancel my hotel reservation in Santo Domingo, will I receive a refund?

Yes, most room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to review the best deals available in Santo Domingo.

What are the top things to see and do in Santo Domingo?

Estadio Azteca, Centro Cultural y Social Veracruzano and Teatro Rafael Solana are just a few of the places to visit in and around Santo Domingo. While you're out sightseeing, Parroquia de San Juan Bautista and Casa del Teatro are a couple of additional sights to visit in Mexico City.

The Best Hotels in Santo Domingo, Mexico City - 2026 Updated Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santo Domingo hotels

1. CASA MEXICANA

Santo Domingo

₹6,592 total

includes taxes & fees

22 Jul - 23 Jul

2. UNAM CIUDAD DE MEXICO CASA DE HUESPEDES

Santo Domingo

₹8,259 total

includes taxes & fees

22 Jul - 23 Jul

3. WeEnjoy Hotels Aeropuerto CDMX

10.8 km from Santo Domingo

Jaishuaa

₹8,282 total

includes taxes & fees

22 Jul - 23 Jul

4. Royal Pedregal Hotel

Tlalpan, 4.6 km from Santo Domingo

Luis Angel

₹12,455 total

includes taxes & fees

27 Jul - 28 Jul

5. Fiesta Inn Insurgentes Sur

4.4 km from Santo Domingo

Carlos

₹11,851 total

includes taxes & fees

7 Aug - 8 Aug

6. Fiesta Inn Plaza Central Aeropuerto

9.2 km from Santo Domingo

salvador isidro

₹10,355 total

includes taxes & fees

2 Aug - 3 Aug

Outdoor pool, pool umbrellas, pool loungers

7. Galeria Plaza San Jeronimo

5.1 km from Santo Domingo

Ayodeji

₹14,777 total

includes taxes & fees

26 Jul - 27 Jul

Deluxe Suite, 1 King Bed | Egyptian cotton sheets, premium bedding, down duvets, in-room safe

8. Econo Express Hotel by Nokte Inn

Benito Juarez, 6.4 km from Santo Domingo

Ashley

₹6,012 total

includes taxes & fees

24 Jul - 25 Jul

9. Holiday Inn Express Mexico Aeropuerto by IHG

10.6 km from Santo Domingo

Mehran

₹10,451 total

includes taxes & fees

11 Aug - 12 Aug

10. Camino Real Aeropuerto Mexico

Venustiano Carranza, 14.5 km from Santo Domingo

Martin

₹13,389 total

includes taxes & fees

14 Aug - 15 Aug

11. Hotel Escala Siglo XXI

Cuauhtémoc, 9.4 km from Santo Domingo

Guillermo

₹3,936 total

includes taxes & fees

27 Jul - 28 Jul

12. Krystal Urban Aeropuerto Cd de Mexico

11.2 km from Santo Domingo

Anthony

₹8,665 total

includes taxes & fees

15 Aug - 16 Aug

13. Hotel Harare

Benito Juarez, 7.1 km from Santo Domingo

RODOLFO FIERRO

₹5,041 total

includes taxes & fees

22 Jul - 23 Jul

14. BelAir Unique, a Wyndham Hotel

7.6 km from Santo Domingo

Ignacio

₹12,604 total

includes taxes & fees

24 Jul - 25 Jul

Shower, free toiletries, hair dryer, towels

15. Hotel Riazor Aeropuerto

9.8 km from Santo Domingo

Yolanda

₹13,164 total

includes taxes & fees

22 Jul - 23 Jul

Rooftop bar, al fresco dining, open daily

16. Fiesta Americana Viaducto Aeropuerto

10.3 km from Santo Domingo

Antonio

₹15,302 total

includes taxes & fees

15 Aug - 16 Aug

17. Hotel Tacubaya & Autosuites

8.3 km from Santo Domingo

Enrique

₹3,243 total

includes taxes & fees

22 Jul - 23 Jul

18. Holiday Inn Mexico Dali Airport by IHG

Venustiano Carranza, 9.9 km from Santo Domingo

Jesus

₹10,366 total

includes taxes & fees

23 Jul - 24 Jul

19. Fiesta Inn Ciudad de Mexico Aeropuerto

Venustiano Carranza, 14.3 km from Santo Domingo

Douglas

₹14,267 total

includes taxes & fees

9 Aug - 10 Aug

20. Fiesta Inn Insurgentes Viaducto

8 km from Santo Domingo

Jason

₹10,604 total

includes taxes & fees

26 Jul - 27 Jul

View all properties

Where to stay in Santo Domingo

Find the best Santo Domingo areas for the activities you enjoy most.

A statue of a woman on a chariot with lions, surrounded by a fountain, in an urban setting with modern buildings.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

See properties

A stone monument with inscriptions, surrounded by lush greenery and a clear sky.

Polanco

Visit the most diverse section of Mexico City for sophisticated shopping, dining, accommodations and sightseeing.

See properties

A row of colorful buildings with balconies and ornate doors.

La Condesa

Enjoy 20th-century history in these two sections of Mexico City, with interesting art and architecture reflecting European influences.

See properties

A grand building with a large golden dome and classical architecture.

Historic Center

Consider a visit to Zócalo and take some time to enjoy the interesting museums during your time in Historic Center. If you want to see more of the city, jump on the metro at Allende Station or Bellas Artes Station.

See properties

A city street at dusk with illuminated buildings, palm trees, and vehicles with light trails.

Reforma

Consider a visit to Angel of Independence Monument and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

See properties

Top Santo Domingo Hotel Reviews

Hotel Canada Central

10/10 Excellent

"Clean and friendly staff always available great location"

Hotel Catedral

10/10 Excellent

"I loved the entrance and restaurant of the Hotel but I wish that the bathroom would have been a bit more updated. The room was clean and the terraza was nice too! It was hard to get from the airport to the Hotel because of traffic and many roads were closed but once we were there it was so close to the Zocalo which I loved!! Definitely walking distance to Palacio de Bellas Artes."

Search Hotels in Santo Domingo, Mexico City

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santo Domingo hotels

1. CASA MEXICANA

2. UNAM CIUDAD DE MEXICO CASA DE HUESPEDES

3. WeEnjoy Hotels Aeropuerto CDMX

4. Royal Pedregal Hotel

5. Fiesta Inn Insurgentes Sur

6. Fiesta Inn Plaza Central Aeropuerto

7. Galeria Plaza San Jeronimo

8. Econo Express Hotel by Nokte Inn

9. Holiday Inn Express Mexico Aeropuerto by IHG

10. Camino Real Aeropuerto Mexico

11. Hotel Escala Siglo XXI

12. Krystal Urban Aeropuerto Cd de Mexico

13. Hotel Harare

14. BelAir Unique, a Wyndham Hotel

15. Hotel Riazor Aeropuerto

16. Fiesta Americana Viaducto Aeropuerto

17. Hotel Tacubaya & Autosuites

18. Holiday Inn Mexico Dali Airport by IHG

19. Fiesta Inn Ciudad de Mexico Aeropuerto

20. Fiesta Inn Insurgentes Viaducto

Where to stay in Santo Domingo

Roma Norte

Polanco

La Condesa

Historic Center

Reforma

Top Santo Domingo Hotel Reviews

Hotel Canada Central

Frequently asked questions

Explore a world of travel with Expedia