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Check availability on Santo Domingo Luxury Hotels

Our top choices for Santo Domingo luxury hotels

Outdoor pool, free pool cabanas, pool umbrellas
Volga, Member of Preferred Hotels & Resorts

Volga, Member of Preferred Hotels & Resorts

Volga, Member of Preferred Hotels & Resorts
4.0 star property
Reforma
9.2 out of 10, Wonderful, (142)
"This hotel was amazing. The decor is beautiful and the service was excellent. Highly recommended!"
United States
Wade
The price is ₹25,552
₹33,090 total
includes taxes & fees
18 Dec - 19 Dec
Volga, Member of Preferred Hotels & Resorts
Interior
Gran Hotel Ciudad de Mexico Zocalo View

Gran Hotel Ciudad de Mexico Zocalo View

Gran Hotel Ciudad de Mexico Zocalo View
4.5 star property
Historic Center
9.6 out of 10, Exceptional, (1092)
"Great stay"
United States
jia
The price is ₹24,214
₹28,936 total
includes taxes & fees
11 Jan - 12 Jan 2026
Gran Hotel Ciudad de Mexico Zocalo View
Outdoor pool, open 10:00 AM to 6:00 PM, pool loungers
Andaz Condesa Mexico City, By Hyatt

Andaz Condesa Mexico City, By Hyatt

Andaz Condesa Mexico City, By Hyatt
5.0 star property
La Condesa
9.0 out of 10, Wonderful, (303)
"Great stay! Awesome friendly staff"
United States
Christian
The price is ₹23,280
₹27,820 total
includes taxes & fees
6 Jan - 7 Jan 2026
Andaz Condesa Mexico City, By Hyatt
Grand Double Room | Dining room
ONTO Alvaro Obregon Mexico City

ONTO Alvaro Obregon Mexico City

ONTO Alvaro Obregon Mexico City
4.0 star property
Roma Norte
9.6 out of 10, Exceptional, (79)
"Very nice hotel and service from the staff. "
United States
ANTONIO
ONTO Alvaro Obregon Mexico City
Exterior
Roso Guest House

Roso Guest House

Roso Guest House
4.0 star property
Roma Norte
9.6 out of 10, Exceptional, (52)
"Room exceeded our expectations, breakfast was amazing, crew was very kind. "
United States
DAVID
The price is ₹28,578
₹34,151 total
includes taxes & fees
21 Dec - 22 Dec
Roso Guest House
Breakfast, lunch, dinner served; Mexican cuisine
Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City
4.0 star property
Historic Center
9.8 out of 10, Exceptional, (2656)
"Great place to stay! "
United States
Guadalupe
The price is ₹16,769
₹20,039 total
includes taxes & fees
13 Jan - 14 Jan 2026
Zocalo Central & Rooftop Mexico City
Penthouse, 1 King Bed (Roma) | Premium bedding, down duvets, minibar, in-room safe
Mondrian Mexico City Condesa

Mondrian Mexico City Condesa

Mondrian Mexico City Condesa
5.0 star property
La Condesa
9.2 out of 10, Wonderful, (812)
"Staff was friendly and the hotel was beautiful! Had a wonderful vacation. "
United States
Cindy
The price is ₹24,498
₹29,275 total
includes taxes & fees
6 Jan - 7 Jan 2026
Mondrian Mexico City Condesa
Lobby
Hyatt Regency Mexico City

Hyatt Regency Mexico City

Hyatt Regency Mexico City
5.0 star property
Polanco
9.4 out of 10, Exceptional, (1334)
"Beautiful location hotel staff "
United States
Rajat
The price is ₹20,592
₹24,607 total
includes taxes & fees
17 Jan - 18 Jan 2026
Hyatt Regency Mexico City
Front of property – evening/night
Historico Central Hotel

Historico Central Hotel

Historico Central Hotel
4.0 star property
Historic Center
9.8 out of 10, Exceptional, (2405)
"Very nice staff, clean rooms, very good breakfast options and close to very city amenities."
United States
Maria
The price is ₹13,125
₹15,684 total
includes taxes & fees
18 Dec - 19 Dec
Historico Central Hotel
Terrace Suite | Egyptian cotton sheets, premium bedding, Select Comfort beds, minibar
HOTEL LUCA

HOTEL LUCA

HOTEL LUCA
4.0 star property
Roma Norte
9.2 out of 10, Wonderful, (315)
"Great location, spotless large room; outstanding cleaning staff, great breakfast on roof patio with fantastic staff. "
United States
Allison
HOTEL LUCA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santo Domingo Hotel Reviews

Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City

10/10 Excellent
"Loved our room and staff so helpful"
Stephanie 4-night trip
Posted 16 hours ago
Zocalo Central & Rooftop Mexico City

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Frequently asked questions

Are you searching for a great accommodation for your luxury holiday in Santo Domingo?
Expedia can help you get a flight to Benito Juarez International Airport (MEX) airport or Toluca, Estado de Mexico (TLC-Toluca Intl.) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a holiday, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel that has a spa, an indoor pool or luxury bedding, Expedia can help you find the best luxury hotel experience that Santo Domingo has to offer.
What's there to see and do in Santo Domingo?
Take in some sights and attractions while you're in Santo Domingo by visiting Paseo de la Reforma, Autódromo Hermanos Rodríguez and Angel of Independence Monument. If you have spare time during your trip, you might want to make a stop at Zócalo and Basilica of Our Lady of Guadalupe.