TOP Spa Hotels in O'Fallon, MO for 2026

A city skyline with a prominent arch bridge and a lit bridge over a calm river reflecting city lights.

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Our top choices for O'Fallon hotels with a spa

Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs

Outdoor pool, open 10:00 AM to 6:00 PM, pool cabanas (surcharge)

1. Ameristar Casino Resort and Spa

St. Charles

Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.

₹14,124

₹18,094 total

includes taxes & fees

7 Sept - 8 Sept

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Choose what matters most at spa hotels in O'Fallon

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top O'Fallon Hotel Reviews

Ameristar Casino Resort and Spa

10/10 Excellent

"Great location and atmosphere! Rooms are so spacious and nice. Will definitely stay again!"

Hilton St. Louis Frontenac

8/10 Good

"It’s was like a castle but finding rooms was a doozy"

Frequently asked questions

Looking for a spa hotel in O'Fallon?

Treat yourself to some time in a luxurious spa hotel and you won't regret it. Discover the lakeside setting in O'Fallon—worth a picture or two! Enjoy the shops and many popular restaurants during your holiday. Hotels with spas are a great way to break out of your routine and add a layer of luxury to your holiday.

What's there to see and do in O'Fallon?

Take in some sights and attractions while you're in O'Fallon by visiting CarShield Field, 9-11 Memorial and Mississippi River. If you have a bit of extra time while you're in the area, you might want to check out Alligator Creek Aquatic Center and Golf Headquarters.

What is a O'Fallon spa hotel?

Spa hotels in O'Fallon provide lodging and have a full on-site spa which offers services including facials as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.

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