A trolley on a street with buildings and a clock tower.

Search Business Hotels in Downtown San Francisco

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Downtown San Francisco Business Hotels

Our top choices for Downtown San Francisco business-friendly hotels

An outdoor seating area with wicker furniture and a fire feature, adjacent to a bar and dining area with modern decor.

1. Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown
3.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (2,323 reviews)
"The breakfast was delicious and the location was great!"
United States
Greg
The price is ₹18,641
₹21,939 total
includes taxes & fees
16 Oct - 17 Oct
Hyatt Place San Francisco Downtown
A spacious lobby with large windows, a seating area with a sofa and chairs, and a counter with a coffee station.

2. LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
Downtown San Francisco
9.6 out of 10, Exceptional, (2,621 reviews)
"Beautiful stay!"
United States
Jennifer
The price is ₹23,458
₹27,608 total
includes taxes & fees
2 Oct - 3 Oct
LUMA Hotel San Francisco
A multi-story hotel with a prominent sign reading "The Handlebar Union Square Hotel."

3. Handlery Union Square Hotel

Handlery Union Square Hotel
3.5 star property
Union Square
8.8 out of 10, Excellent, (3,573 reviews)
"Great rooms, great price!"
United States
John
The price is ₹13,957
₹16,426 total
includes taxes & fees
16 Oct - 17 Oct
Handlery Union Square Hotel
A hotel reception area with a polished marble floor, wooden paneling, and a reception desk with a computer and a telephone.

4. The Pickwick Hotel

The Pickwick Hotel
3.5 star property
Downtown San Francisco
7.8 out of 10, Good, (1,559 reviews)
"Great stay."
United States
Jesus
The price is ₹9,545
₹11,215 total
includes taxes & fees
18 Oct - 19 Oct
The Pickwick Hotel
A modern building facade with vertical wooden slats, a glass entrance, and a sign reading "La Société Bar & Cafe".

5. Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1,284 reviews)
"The best hotel ever"
United States
Gabriela
The price is ₹16,155
₹22,828 total
includes taxes & fees
16 Oct - 17 Oct
Hyatt Regency San Francisco Downtown SOMA
A modern bar area with a curved ceiling and large windows offering a city view.

6. San Francisco Marriott Marquis

San Francisco Marriott Marquis
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (1,237 reviews)
"It was a great location and everyone was helpful"
United States
susan
The price is ₹15,382
₹22,439 total
includes taxes & fees
2 Oct - 3 Oct
San Francisco Marriott Marquis
A hotel with a modern design, featuring a prominent 'PARC 55' sign, a 'Barbary Coach' restaurant, and a view of the street with light trails from moving vehicles.

7. Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel
4.0 star property
Union Square
8.8 out of 10, Excellent, (1,655 reviews)
"Really great area to stay!"
United States
Janet
The price is ₹15,624
₹18,389 total
includes taxes & fees
16 Oct - 17 Oct
Parc 55 San Francisco - A Hilton Hotel
A spacious lobby with modern seating, a large abstract sculpture, and a high ceiling with linear lighting.

8. Hyatt Regency San Francisco

Hyatt Regency San Francisco
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (2,483 reviews)
"great breakfast buffet and amazing location"
United States
Juan
The price is ₹20,968
₹29,080 total
includes taxes & fees
27 Sept - 28 Sept
Hyatt Regency San Francisco
A modern interior with a fireplace, sofas, a coffee table, and a bookshelf.

9. Grand Hyatt San Francisco

Grand Hyatt San Francisco
4.0 star property
Union Square
9.0 out of 10, Wonderful, (1,009 reviews)
"Great stay. Would come back!"
United States
Stephanie
The price is ₹14,458
₹21,524 total
includes taxes & fees
23 Oct - 24 Oct
Grand Hyatt San Francisco
A tall hotel with a modern design, a prominent entrance, and a view of the city skyline.

10. Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (3,264 reviews)
"Really good hotel everything was excellent!!"
United States
Alpa
The price is ₹14,031
₹16,514 total
includes taxes & fees
25 Oct - 26 Oct
Hilton San Francisco Financial District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Downtown San Francisco Hotel Reviews

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

10/10 Excellent
"Great place, centrally located, and great staff."
John 1-night trip
Posted 1 hour ago
Chancellor Hotel on Union Square

Frequently asked questions

Why book your business-friendly hotel in Downtown San Francisco with Expedia?
At Expedia, our top task is to help you locate an excellent stay at the right price. From luxurious, corporate-friendly escapes to affordable hotels filled with conveniences, you'll have your next work trip arranged in a couple of clicks.
How can I find cheap business-friendly hotels in Downtown San Francisco?
When work takes you to Downtown San Francisco, our "business friendly" filter will help you find the perfect hotel. From fast WiFi to conference spaces and in-room desks, they have the amenities you need to do your job. You can also refine your search by your preferred star rating and budget to view the most affordable stays.

Explore a world of travel with Expedia