A red train on tracks, palm trees, and modern buildings.

Search Spa Hotels in Central San Diego

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Central San Diego Spa Hotels

Tonight
24 Sept - 25 Sept
Tomorrow
25 Sept - 26 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Our top choices for Central San Diego hotels with a spa

A hotel with a curved entrance, palm trees, and a parking lot.
A lobby with seating areas, a piano, and a reception desk.
A bar area with wooden chairs and tables, a bar counter with various bottles, and a sign reading "BEACH BUMS CATER HERE".
A spacious lobby with a central round table, a reception desk, and a bar area.

1. Handlery Hotel

Handlery Hotel
Mission Valley
  • Surrender to spa treatments and poolside luxury at this hotel with massage rooms and a beautiful heated outdoor pool and hot tub.
₹9,881
₹11,358 total
includes taxes & fees
28 Sept - 29 Sept
Handlery Hotel
A modern bathroom with a shower, a towel rack, and a bench.
A pathway leading to a building labeled "LEGACY Hotel."
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.
A modern interior with wooden panel ceilings, patterned seating, and a central bar area.

2. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
Mission Valley
  • Indulge in a serene escape at this upscale hotel with a full-service spa, outdoor pool with free cabanas, and couples massage treatments.
₹14,936
₹17,169 total
includes taxes & fees
29 Sept - 30 Sept
Legacy Resort Hotel & Spa
A spa room with a bed, a bathtub, and a large window with curtains. There are candles and plants on the windowsill.
A spacious lobby with a high ceiling, large windows, and a view of palm trees.
A modern dining area with a glass table, candles, and wicker chairs.
An outdoor seating area with a canopy, lounge chairs, and a fire pit.

3. San Diego Mission Bay Resort

San Diego Mission Bay Resort
Mission Bay
  • Unwind at this bay-view resort offering garden massages, poolside lounging, and a rejuvenating full-service spa retreat.
₹23,803
₹32,416 total
includes taxes & fees
19 Oct - 20 Oct
San Diego Mission Bay Resort
A spacious indoor area with large windows overlooking the ocean, featuring modern furniture and a wooden floor.
A sunlit outdoor area with a curved staircase leading to a beach view, outdoor seating, and a palm tree.
A covered balcony with a view of the beach, featuring a railing, a table with chairs, and a bottle of wine.
A poolside area with sun loungers and white canopies, palm trees in the background, and a clear sky.

4. La Jolla Beach and Tennis Club

La Jolla Beach and Tennis Club
La Jolla Shores
  • Mediterranean beachfront wellness awaits with private spa cabanas, golf course, and beach access for total rejuvenation.
₹16,090
₹26,003 total
includes taxes & fees
20 Oct - 21 Oct
La Jolla Beach and Tennis Club
A modern building with a sloped roof and large windows, surrounded by palm trees and a well-maintained garden.
A spacious lobby with a high ceiling, stone flooring, and wicker furniture.
A restaurant with high ceilings, large windows, and a patterned carpet. Tables are set with chairs and place settings.
An outdoor patio with round tables and chairs, large umbrellas, and a marina view in the background.

5. Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
Point Loma
  • Blissful bay views and relaxing massages set the scene for a restorative escape at this waterfront sanctuary with bubbling hot tubs.
₹13,591
₹15,622 total
includes taxes & fees
25 Oct - 26 Oct
Best Western Plus Island Palms Hotel & Marina
An aerial view of a resort with a central swimming pool, palm trees, and a view of the ocean and beach.
An outdoor dining area with tables and chairs, umbrellas, and string lights against a sunset backdrop.
A living room with a fireplace, a television, a sofa, a chair, a round coffee table, and a view of the ocean through glass doors.
A modern building with a curved roof, surrounded by lush tropical vegetation.

6. Paradise Point Resort & Spa

Paradise Point Resort & Spa
Mission Bay
  • Immerse in waterfront tranquility with hot stone massages and aromatherapy at this resort spa retreat.
₹19,073
₹26,990 total
includes taxes & fees
25 Oct - 26 Oct
Paradise Point Resort & Spa
A spacious lobby with a reception desk, seating area, and artwork on the walls.
A hotel entrance with a covered walkway, palm trees, and a modern building in the background.
A modern hotel room with a large window offering a view of the sea, a sofa, a dining table, and a TV on a wooden cabinet.
A resort pool with a lazy river, palm trees, and a view of the ocean.

7. Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
Mission Bay
  • Experience coastal tranquility at this spa hotel with bay views, heated pools, and waterslides.
₹19,053
₹26,967 total
includes taxes & fees
30 Sept - 1 Oct
Hyatt Regency Mission Bay Spa and Marina
A spacious lobby with a marble reception desk, comfortable seating, and potted plants.
A beachfront hotel with a balcony overlooking the ocean, a walkway lined with palm trees, and a view of the beach.
A pool area with umbrellas, palm trees, and a view of the ocean.
A balcony with a view of the ocean, palm trees, and outdoor seating.

8. Pacific Terrace Hotel

Pacific Terrace Hotel
Pacific Beach
  • Escape to a beachfront wellness sanctuary with heated pool, private spa services, and ocean-view hot tub for a serene coastal retreat.
₹25,563
₹29,383 total
includes taxes & fees
14 Oct - 15 Oct
Pacific Terrace Hotel
A couple standing in a lobby with a display of vases and plants.
A rooftop lounge area with outdoor seating, a pool, and umbrellas.
A spacious lobby with a high ceiling, a large sectional sofa, multiple seating areas, and a modern chandelier.
A modern bar area with a curved counter, multiple bar stools, and a large window offering a view of the cityscape.

9. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
Downtown San Diego
  • Rooftop spa retreat delivers poolside massages and soothing therapies in the heart of city centre San Diego.
₹17,541
₹24,667 total
includes taxes & fees
27 Sept - 28 Sept
Omni San Diego Hotel at the Ballpark
A dining area with a checkered floor, wooden chairs, a marble table, and a view of tropical foliage through large windows.
An aerial view of a coastal city with a marina, beachfront hotels, and a prominent hotel with a large balcony overlooking the ocean.
A couple walking through a wooden door into a building with a tropical garden view.
A room with a large glass door leading to a grassy deck with a table and chairs, overlooking a marina with boats and a clear sky.

10. Catamaran Resort and Spa

Catamaran Resort and Spa
Mission Beach
  • Luxurious beachside retreat offers 10 spa treatment rooms, waterfront yoga, and a serene bay location for ultimate wellness.
₹19,073
₹27,017 total
includes taxes & fees
25 Oct - 26 Oct
Catamaran Resort and Spa
View all properties

Choose what matters most at spa hotels in Central San Diego

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Central San Diego Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

8/10 Good
"You get basic service"
Silvestre 2-night trip
Posted 1 hour ago
Hampton Inn San Diego/Mission Valley
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

10/10 Excellent
"Front desk staff was so welcoming and helpful even with last minute late night check out. Courtyard was beautiful. Property and room was modern, quiet and nicely maintained. It would be even better if there was easily visible signage from car at night for 1st floor rooms and if there was a ramp instead of the few steps. My room was facing courtyard at right rear of property with view of parking lot."
Katherine 1-night trip
Posted 4 hours ago
Crowne Plaza San Diego - Mission Valley by IHG
California Suites Hotel

California Suites Hotel

10/10 Excellent
"Excellent"
Keven 3-night trip
Posted 10 hours ago
California Suites Hotel
Kings Inn San Diego

Kings Inn San Diego

10/10 Excellent
"CLEAN ROOM OUTDOOR POOL"
George 1-night trip
Posted 18 hours ago
Kings Inn San Diego
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent
"Everything was nice, would recommend"
Ryan 4-night trip
Posted 20 hours ago
The Alcala Hotel Mission Valley/Seaworld
The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo

8/10 Good
"The lobby was clean and the staff was nice. My unit was upstairs and it was clean and smelled really good too the only thing was the bathroom doesn’t have a working fan so I showered with the window open….you’re welcome."
Robert 1-night trip
Posted 2 days ago
The Atwood Hotel San Diego - SeaWorld/Zoo
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

10/10 Excellent
"Affordability and location can’t be beat. Staff is extremely helpful and attentive, and the amenities are great."
Karla 1-night trip
Posted 2 days ago
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Explore a world of travel with Expedia