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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Stay at this spa hotel in San Luis Obispo. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

9.2/10 Wonderful! (1,369 reviews)

We were treated with the most personal touch, it was clean, and the food was awesome

Reviewed on 29 Jan 2026

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Stay at this motel in San Luis Obispo. Enjoy free Wi-Fi, free parking and premium TV channels. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,164 reviews)

All was great!

Reviewed on 31 Jan 2026

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Stay at this golf hotel in Avila Beach. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.4/10 Exceptional! (1,000 reviews)

Vibe: From the moment you walk in, the atmosphere is great--decorated in a Hacienda style that feels warm & authentic. Everything is clean & feels relatively new. Some minor scuffs on high traffic areas & some areas of the rug are visibly worn but not gross in anyway. Music playing & fireplace going, ...

Reviewed on 30 Jan 2026

See all 1,860 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.