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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Stay at this spa hotel in San Luis Obispo. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Stay at this motel in San Luis Obispo. Enjoy free Wi-Fi, free parking and premium TV channels. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,282 reviews)

"Stayed one night on trip from SFO to LA. We specifically picked Thursday night as we wanted to check out the famous Farmers Market. This hotel was about a 10 minute walk away which was perfect to avoid parking hassles. The room was large, the bed very comfortable and the grounds very quiet. We will ..."

Reviewed on 26 Jun 2026

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Stay at this golf hotel in Avila Beach. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.6/10 Exceptional! (1,001 reviews)

"It was really clean Staff were really respectful. The breakfast was good. The pie was good and they have real good service and the cleaning staff also have real good service and they’re always asking you if you need anything and I’m really appreciated of everything they did for me thank you so ..."

Reviewed on 22 Jun 2026

See all 403 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.