San Luis Obispo Wine Country Luxury Holidays 2026

Photo by Anthony Hilario

Plan, book, travel with confidence
Better together
Save up to ₹100,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Stay at this spa hotel in San Luis Obispo. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Stay at this motel in San Luis Obispo. Enjoy free Wi-Fi, free parking and premium TV channels. Our guests praise the helpful staff and the clean rooms in their ...

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Stay at this golf hotel in Avila Beach. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.6/10 Exceptional! (1,001 reviews)

"The hotel is a great location and offers amazing amenities. The rooms are clean and well maintained. I have been staying here for 8 years for both business and getaway visits. Never disappoints."

Reviewed on 1 Oct 2026

See all 1,940 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.