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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Stay at this spa hotel in San Luis Obispo. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

9.2/10 Wonderful! (1,394 reviews)

My little family always comes here when were in the area, but usually just to dine. This was our first time staying and we were lucky enough to get the Safari Room. This room was really awesome and we were very comfortable. Staff is always super helpful. We will be back for sure. Thanks for the awesome ...

Reviewed on 23 Mar 2026

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Stay at this motel in San Luis Obispo. Enjoy free Wi-Fi, free parking and premium TV channels. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,202 reviews)

They had no beds available larger than a twin. The air-conditioning in the room didn’t work well and was louder than a jet engine. By the time I returned from dinner, there was no parking on the property Thank goodness the weather was decent so I could sleep with an open window because if I had to ...

Reviewed on 23 Mar 2026

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Stay at this golf hotel in Avila Beach. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.6/10 Exceptional! (1,000 reviews)

Loved my experience and the location. My room was perfect, enjoyed the hot tub and proximity to the beach. Also, was felt extra spoiled by all the extra goodies the staff wouldn’t stop giving us…will be back!!

Reviewed on 14 Mar 2026

See all 1,863 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.