San Luis Obispo Wine Country Luxury Holidays 2026

Photo by Anthony Hilario

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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Stay at this spa hotel in San Luis Obispo. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

9.2/10 Wonderful! (1,548 reviews)

"We loved our one night stay at the Madonna Inn. We stayed in the Daisy Mae room and it was amazing! We loved the shower and the waterfall sink. We enjoyed the pool and hottub area, and had a lovely drink at the bar and enjoyed the live music there. Would highly recommend this hotel to anyone who ..."

Reviewed on 15 Aug 2026

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Stay at this motel in San Luis Obispo. Enjoy free Wi-Fi, free parking and premium TV channels. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,347 reviews)

"Great place to stay with family will stay again"

Reviewed on 16 Aug 2026

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Stay at this golf hotel in Avila Beach. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.6/10 Exceptional! (1,000 reviews)

"Loved It Here.Dtaff was helpful and welcoming"

Reviewed on 10 Aug 2026

See all 1,905 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.