Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road, San Luis Obispo, CA

6 min drive from California Polytechnic State University

Stay at this 3.5-star spa hotel in San Luis Obispo. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the pool and the bar in their reviews. ...

9.2/10 Wonderful! (1,202 reviews)

"The room experience is 10/10. The steak house is mid. I would rather eat elsewhere for the steak price and ensure it’s an evenly cooked steak. The cafe is mid as well. The pink cake is blah. You’re paying for the novelty of the decor and atmosphere. The architecture of the rooms and decor is honestly ..."

Reviewed on 17 Jul 2025

Avenue Inn Downtown San Luis Obispo

345 Marsh St, San Luis Obispo, CA

4 min drive from California Polytechnic State University

Stay at this motel in San Luis Obispo. Enjoy free Wi-Fi, free parking and premium TV channels. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,035 reviews)

Cute and quiet

"This was a cute little room. Nothing flashy but that wasn't expected. It was quite and I felt safe here. I would stay here again."

Reviewed on 17 Jul 2025

Avila La Fonda Hotel

101 San Miguel St, Avila Beach, CA

22 min drive from California Polytechnic State University

Stay at this 4-star golf hotel in Avila Beach. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (1,001 reviews)

"Over all had a great experience"

Reviewed on 12 Jul 2025

See all 1,820 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.