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Top Adventure Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.4/10 Very good! (2,162 reviews)

"We had a wonderful stay. Everyone we came in contact with during our stay was so kind and caring. It’s so nice, especially when you are going thru a difficult, scary time going thru testing at Mayo Clinic."

Reviewed on 25 Jun 2026

Willow Inn Suites Rochester

4323 Highway 52 North, West Frontage Rd Rochester MN

10 min drive from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff in their reviews. ...

Hotel Indigo Rochester – Mayo Clinic Area by IHG

220 S Broadway Rochester MN

6 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, a rooftop terrace and breakfast (surcharge). Our guests praise the restaurant and the helpful ...

8.8/10 Excellent! (1,002 reviews)

"This is a well located property, close to restaurants, shopping, and Mayo Clinic. The staff was very understanding of the fluidity of my stay due to appointments at Mayo Clinic. The property doesn't have some of the amenities of other more expensive hotels in the area, but it is a great value for ..."

Reviewed on 25 Jun 2026

See all 916 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.