𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 St. Charles (2026)

An aerial view of a town with industrial buildings, roads, and green areas.

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Our top choices for St. Charles hotels

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

1. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Jason

₹7,149

₹8,230 total

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A conference room with round tables and chairs, white walls, and a carpeted floor.

An indoor swimming pool with a checkered tile wall, a door labeled 'Mechanical Room,' and a window with a view outside.

A gym with treadmills, elliptical machines, and a stationary bike.

2. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Richard

₹8,111

₹9,338 total

includes taxes & fees

8 Oct - 9 Oct

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A small, well-organized pantry with shelves stocked with snacks and beverages.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

3. Spark by Hilton Rochester South

Rochester

Helena

₹8,446

₹9,723 total

includes taxes & fees

13 Sept - 14 Sept

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

A hotel lobby with seating, a fireplace, a clock, and a reception area.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

4. AmericInn by Wyndham Winona

Winona

SANDRA

₹11,486

₹12,821 total

includes taxes & fees

20 Sept - 21 Sept

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

5. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Jon

₹10,546

₹12,141 total

includes taxes & fees

18 Sept - 19 Sept

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

6. Hampton Inn Rochester-South

Rochester

Lynne

₹8,911

₹10,259 total

includes taxes & fees

1 Oct - 2 Oct

A modern hotel lobby with a reception desk, seating area, and a dining space.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

A Holiday Inn Express building with a stone facade and illuminated signage.

7. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Dezel

₹9,544

₹10,988 total

includes taxes & fees

11 Sept - 12 Sept

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A bar with wooden stools and a neon sign.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

An indoor swimming pool with a slide, seating area, and a large frog statue.

8. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Cathy

₹7,594

₹8,742 total

includes taxes & fees

20 Sept - 21 Sept

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A hotel room with a kitchen area, a bed, a TV, and a seating area.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

9. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

Margita

₹8,887

₹10,231 total

includes taxes & fees

18 Sept - 19 Sept

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A garden with a water feature, rocks, and yellow umbrellas.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

10. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Bill

₹10,192

₹11,733 total

includes taxes & fees

11 Sept - 12 Sept

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

11. Econo Lodge Mayo Clinic Area

Rochester

James

₹6,627

₹7,629 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

A Microtel Inn & Suites building with a signboard, a parking lot, and a clear sky.

A reception area with a reception desk, two armchairs, a clock, and a framed artwork on the wall.

A hotel room with a large window, a clock, a framed picture of pottery, a desk with a computer, and a seating area with patterned chairs.

12. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Rochester

Siddhartha

₹6,587

₹7,584 total

includes taxes & fees

9 Sept - 10 Sept

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

13. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

Vickie

₹11,545

₹13,292 total

includes taxes & fees

18 Sept - 19 Sept

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern lounge area with seating, a fireplace, and a bar area.

14. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Heather

₹12,473

₹14,360 total

includes taxes & fees

26 Sept - 27 Sept

A hotel room with two beds, a desk with a chair, a TV, and a large waterfall painting on the wall.

A reception area with a modern design, featuring a check-in counter, a door, and a small seating area with red stools.

A breakfast area with a wooden wall, a clock, and a coffee machine.

A hotel room with large windows, a clock, and framed pictures on the walls.

15. Super 8 by Wyndham Winona MN

Winona

Noel

₹5,859

₹6,657 total

includes taxes & fees

13 Sept - 14 Sept

A modern hotel lobby with a dining area, seating arrangements, and a stone fireplace.

An outdoor patio area with stone walls, a stone fireplace, and multiple tables and chairs.

A hotel with a modern design, featuring a stone facade and a covered entrance.

16. Fairfield Inn & Suites by Marriott Winona

Winona

Mary

₹12,672

₹14,145 total

includes taxes & fees

20 Sept - 21 Sept

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A coffee station with two espresso machines and a variety of coffee pods and cups.

A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.

17. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

Janet

₹10,394

₹11,967 total

includes taxes & fees

12 Sept - 13 Sept

A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

A reception area with a counter, a clock, a desk with a computer, and a framed picture on the wall.

A gym with treadmills, an elliptical, and a stationary bike.

A breakfast area with a coffee station, a refrigerator, and a dining table with chairs.

18. Days Inn by Wyndham Winona

Winona

LeAndre

₹6,426

₹7,173 total

includes taxes & fees

1 Oct - 2 Oct

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

A hotel room with a bed, bedside table, and a window with curtains.

19. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

Amanda

₹12,946

₹14,904 total

includes taxes & fees

18 Sept - 19 Sept

A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

A modern building with large windows and a parking lot.

A hotel room with a sofa, two beds, a large window, and a framed artwork on the wall.

A reception area with a wooden reception desk, a clock, and a wall-mounted display.

20. Kahler Inn and Suites - Mayo Clinic Area

Downtown Rochester

Greg

₹11,821

₹13,610 total

includes taxes & fees

17 Sept - 18 Sept

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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

See all hotels in St. Charles

Top St. Charles Hotel Reviews

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Wish breakfast was included in the room price but great hotel and not too far from Mayo Clinic they do have a shuttle service"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"The property is well-maintained, friendly staff, and walking distance to all amenities. We truly enjoyed our stay!"

Express Suites Riverport Inn & Suites

8/10 Good

"We loved the pool and hours of use. Very nice restaurant/ bar area to gather together. The breakfast was amazing!"

Hampton Inn Rochester-South

10/10 Excellent

"Would recommend!!!"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Everything was exceptional"

Aspen Select

10/10 Excellent

"The room had everything we needed.Restaurant right next Door.We would return."

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Everything"

Hyatt House Rochester/Mayo Clinic Area

8/10 Good

"Great location, 5 minute walk to Mayo. Great pillows, cold AC! Both very important to us. 4th floor patio is awesome. Staff is very friendly and helpful! Breakfast was also very good. Forgot to mention, with all of the construction around Mayo, this place was super easy to get in and out of."

More cheap stays in St. Charles

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

₹5,484

₹6,314 total

4 Oct - 5 Oct

includes taxes & fees

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

₹5,859

₹6,657 total

13 Sept - 14 Sept

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

₹5,953

₹6,854 total

8 Sept - 9 Sept

includes taxes & fees

8/10 Very good! (1,017 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

₹8,859

₹10,199 total

10 Sept - 11 Sept

includes taxes & fees

8.8/10 Excellent! (1,002 reviews)

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN

₹8,887

₹10,231 total

18 Sept - 19 Sept

includes taxes & fees

8.2/10 Very good! (1,012 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

₹9,544

₹10,988 total

11 Sept - 12 Sept

includes taxes & fees

Frequently asked questions

Where is the best place to stay in St. Charles?

Kahler Grand Hotel, located 20.6 mi (33.1 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Inn and Suites - Mayo Clinic Area and Med City Inn & Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

Explore a world of travel with Expedia

Book Hotels in St. Charles on Expedia.com

St. Charles Hotels from ₹6,314

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for St. Charles hotels

1. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

2. Comfort Inn & Suites Rochester South Mayo Clinic

3. Spark by Hilton Rochester South

4. AmericInn by Wyndham Winona

5. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

6. Hampton Inn Rochester-South

7. Holiday Inn Express Rochester South - Mayo Area by IHG

8. AmericInn by Wyndham Rochester Near Mayo Clinic

9. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

11. Econo Lodge Mayo Clinic Area

12. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

13. Home2 Suites by Hilton Rochester Mayo Clinic Area

14. Residence Inn by Marriott Rochester Mayo Clinic Area South

15. Super 8 by Wyndham Winona MN

16. Fairfield Inn & Suites by Marriott Winona

17. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

18. Days Inn by Wyndham Winona

19. TownePlace Suites by Marriott Rochester Mayo Clinic Area

20. Kahler Inn and Suites - Mayo Clinic Area

Learn more about St. Charles

Top St. Charles Hotel Reviews

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Express Suites Riverport Inn & Suites

Hampton Inn Rochester-South

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Aspen Select

Med City Inn & Suites - Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

More cheap stays in St. Charles

Birch Hill Suite Rochester – Med City

Super 8 by Wyndham Winona MN

Med City Inn & Suites - Mayo Clinic Area

Brentwood Inn & Suites

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Holiday Inn Express Rochester South - Mayo Area by IHG

Frequently asked questions

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