𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 St. Charles (2026)

An aerial view of a town with industrial buildings, roads, and green areas.

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Our top choices for St. Charles hotels

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

1. Hampton Inn Rochester-South

Rochester

dennis

₹8,512

₹9,799 total

includes taxes & fees

8 Nov - 9 Nov

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A small, well-organized pantry with shelves stocked with snacks and beverages.

2. Spark by Hilton Rochester South

Rochester

Stanton

₹7,709

₹8,875 total

includes taxes & fees

8 Nov - 9 Nov

A modern hotel lobby with a reception desk, seating area, and a dining space.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

3. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Rick

₹8,313

₹9,571 total

includes taxes & fees

19 Nov - 20 Nov

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A cozy living room with a fireplace, a staircase, and a dining area.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

4. Stone Mill Hotel & Suites

Lanesboro

Bernie

₹9,919

₹10,651 total

includes taxes & fees

3 Nov - 4 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

A hotel lobby with seating, a fireplace, a clock, and a reception area.

5. AmericInn by Wyndham Winona

Winona

Jonathan

₹12,125

₹13,535 total

includes taxes & fees

15 Nov - 16 Nov

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A reception area with a curved counter, ceiling lights, and a potted plant.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

6. Brentwood Inn & Suites

Downtown Rochester

Elaine

₹11,336

₹13,051 total

includes taxes & fees

23 Oct - 24 Oct

An indoor swimming pool with a slide, seating area, and a large frog statue.

A bar with wooden stools and a neon sign.

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

7. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

blake

₹7,006

₹8,065 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern bar area with seating and a counter.

A modern indoor pool area with lounge chairs and a pool.

8. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Kimberley

₹11,998

₹13,812 total

includes taxes & fees

29 Oct - 30 Oct

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

9. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Alvaro

₹6,778

₹7,803 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A compact laundry area with a washing machine, dryer, and a water fountain.

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

10. Econo Lodge Mayo Clinic Area

Rochester

Ashley

₹6,247

₹7,192 total

includes taxes & fees

15 Nov - 16 Nov

A multi-story building with a balcony, surrounded by various potted plants and flowers.

A bedroom with a four-poster bed, a sofa, a desk, and a fireplace.

An outdoor patio with tables and chairs, green umbrellas, and a wooden deck.

A bedroom with a four-poster bed, a sitting area with a sofa, a small table with a vase, and a bathtub.

11. Green Gables Inn

Lanesboro

Gary

₹9,718

₹10,434 total

includes taxes & fees

26 Oct - 27 Oct

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A kitchen with a waffle maker, a waffle iron, and a waffle maker instruction manual.

A hotel room with a desk, a chair, a flat-screen TV mounted on the wall, and a lamp on the desk.

A snack bar with a variety of packaged snacks, a refrigerator stocked with beverages, and a microwave.

12. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Terri

₹7,282

₹8,383 total

includes taxes & fees

22 Nov - 23 Nov

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

13. Quality Inn & Suites Mayo Clinic Area

Rochester

Jessica

₹6,432

₹7,507 total

includes taxes & fees

13 Nov - 14 Nov

A hotel room with two beds, a desk, a chair, and a lamp.

A living room with a brick fireplace, two armchairs with decorative pillows, and a framed map on the wall.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

A hotel lobby with a dining area, a fireplace, and a television displaying a map.

14. Country Trails Inn & Suites

Preston

Jeannie

₹11,949

₹13,189 total

includes taxes & fees

28 Oct - 29 Oct

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern restaurant with a counter, seating area, and a TV screen.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

15. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

₹10,359

₹11,925 total

includes taxes & fees

6 Nov - 7 Nov

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

16. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

James

₹10,760

₹12,576 total

includes taxes & fees

23 Oct - 24 Oct

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern lounge area with seating, a fireplace, and a bar area.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

17. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Chee

₹12,942

₹14,900 total

includes taxes & fees

13 Nov - 14 Nov

A modern kitchen with a central island, wooden cabinets, and pendant lighting.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

18. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

Cory

₹12,942

₹14,900 total

includes taxes & fees

6 Nov - 7 Nov

A modern hotel lobby with a dining area, seating arrangements, and a stone fireplace.

An outdoor patio area with stone walls, a stone fireplace, and multiple tables and chairs.

A hotel with a modern design, featuring a stone facade and a covered entrance.

An indoor swimming pool with clear glass walls, a tiled floor, and a few chairs around the pool area.

19. Fairfield Inn & Suites by Marriott Winona

Winona

Leanne

₹12,668

₹14,141 total

includes taxes & fees

15 Nov - 16 Nov

A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.

A hotel room with a large bed, a desk, a chair, a microwave, and a framed picture on the wall.

A bar area with a long counter, multiple bar stools, and a television mounted above the bar.

A banquet hall with round tables, chairs, chandeliers, and a fireplace.

20. Kahler Grand Hotel

Downtown Rochester

Christina

₹13,368

₹15,390 total

includes taxes & fees

3 Nov - 4 Nov

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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

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Top St. Charles Hotel Reviews

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good

"Staff was excellent"

The Plaza Hotel & Suites Winona

8/10 Good

"Wa"

Express Suites Riverport Inn & Suites

10/10 Excellent

"Nice hotel clean.."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Very nice place, convient, clean"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good

"."

Aspen Select

8/10 Good

"Small area to park in and not easy to get to"

Super 8 by Wyndham Winona MN

8/10 Good

"The property is conveniently located where it's just off of the round-about & close to the grocery store, gas station, Target shopping store, Farm & Fleet, etc. Staff was helpful in getting a room close to the door & a flight of stairs for senior citizen like us with arhritis & special needs. I specially liked the breakfast of coffee, waffle, yogurt, etc. Too bad there's no egg for my protein needs. The bathroom was very clean. I like the body wash, shampoo & conditioner dispensers. However, the table needs a lamp on the table, an ironing board, and some hangers. Other than that, everything's great. We had a comfortable and wonderful stay! Thank you very much. We will come back again!"

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

₹4,676

₹5,313 total

15 Nov - 16 Nov

includes taxes & fees

7.6/10 Good! (1,006 reviews)

Quality Inn near Medical Center

5708 Bandel Road NW Rochester MN

₹5,942

₹6,841 total

12 Nov - 13 Nov

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

₹6,713

₹7,729 total

22 Nov - 23 Nov

includes taxes & fees

7.8/10 Good! (1,032 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

₹8,313

₹9,571 total

19 Nov - 20 Nov

includes taxes & fees

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN

₹8,941

₹10,293 total

28 Oct - 29 Oct

includes taxes & fees

8.2/10 Very good! (1,000 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

₹11,336

₹13,051 total

23 Oct - 24 Oct

includes taxes & fees

Frequently asked questions

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

Explore a world of travel with Expedia

Book Hotels in St. Charles on Expedia.com

St. Charles Hotels from ₹5,313

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for St. Charles hotels

1. Hampton Inn Rochester-South

2. Spark by Hilton Rochester South

3. Holiday Inn Express Rochester South - Mayo Area by IHG

4. Stone Mill Hotel & Suites

5. AmericInn by Wyndham Winona

6. Brentwood Inn & Suites

7. AmericInn by Wyndham Rochester Near Mayo Clinic

8. Hyatt House Rochester/Mayo Clinic Area

9. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10. Econo Lodge Mayo Clinic Area

11. Green Gables Inn

12. Comfort Inn & Suites Rochester South Mayo Clinic

13. Quality Inn & Suites Mayo Clinic Area

14. Country Trails Inn & Suites

15. Home2 Suites by Hilton Rochester Mayo Clinic Area

16. EVEN Hotel Rochester - Mayo Clinic Area by IHG

17. Residence Inn by Marriott Rochester Mayo Clinic Area South

18. TownePlace Suites by Marriott Rochester Mayo Clinic Area

19. Fairfield Inn & Suites by Marriott Winona

20. Kahler Grand Hotel

Learn more about St. Charles

Top St. Charles Hotel Reviews

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

The Plaza Hotel & Suites Winona

Express Suites Riverport Inn & Suites

Hyatt House Rochester/Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Aspen Select

Super 8 by Wyndham Winona MN

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Quality Inn near Medical Center

Med City Inn & Suites - Mayo Clinic Area

Holiday Inn Express Rochester South - Mayo Area by IHG

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Brentwood Inn & Suites

Frequently asked questions

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