The Best Hotels Closest to Mayo Clinic in Rochester - 2026 Updated Prices

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Our top choices for Mayo Clinic hotels

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

A modern hotel room with a bed, desk, and kitchenette.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

howard

₹11,216

₹12,913 total

includes taxes & fees

12 Nov - 13 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Brien

₹11,448

₹13,180 total

includes taxes & fees

6 Nov - 7 Nov

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern interior with a large dining table, sofas, and a kitchen area.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

3. The Berkman

Folwell, 1.4 km from Mayo Clinic

Suzette

₹18,044

₹20,981 total

includes taxes & fees

21 Nov - 22 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

₹13,005

₹14,972 total

includes taxes & fees

13 Nov - 14 Nov

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

A hotel room with a bed, bedside table, and a window with curtains.

5. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Cory

₹13,005

₹14,972 total

includes taxes & fees

6 Nov - 7 Nov

A modern indoor patio with a fire feature, seating, and large windows.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

James

₹10,812

₹12,637 total

includes taxes & fees

23 Oct - 24 Oct

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A modern kitchen with a built-in microwave, a coffee machine, and a sink.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Amanda

₹10,822

₹12,648 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A hotel room with a large round table, two sofas, a TV, and a bed.

A person at a checkout counter in a store, with various snack items and a sign indicating a price of $1.50.

A storage cabinet with multiple shelves containing kitchen appliances, glassware, and board games.

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Kevin

₹10,632

₹12,240 total

includes taxes & fees

9 Nov - 10 Nov

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

9. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

₹11,216

₹12,912 total

includes taxes & fees

14 Nov - 15 Nov

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A conference room with a long table, multiple chairs, and decorative wall art.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

₹10,731

₹12,355 total

includes taxes & fees

6 Nov - 7 Nov

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

11. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Ashley

₹6,338

₹7,297 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern bar area with seating and a counter.

12. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Elsie

₹12,056

₹13,879 total

includes taxes & fees

29 Oct - 30 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

13. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

₹10,409

₹11,983 total

includes taxes & fees

5 Nov - 6 Nov

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

14. Aspen Suites

1.2 km from Mayo Clinic

Douangta

₹13,447

₹16,255 total

includes taxes & fees

23 Oct - 24 Oct

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A reception area with a curved counter, ceiling lights, and a potted plant.

15. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Elaine

₹11,391

₹13,114 total

includes taxes & fees

23 Oct - 24 Oct

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

An outdoor dining area with wooden beams, tables, and chairs.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

16. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Naomi

₹10,157

₹11,693 total

includes taxes & fees

24 Oct - 25 Oct

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

17. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Jessica

₹6,427

₹7,501 total

includes taxes & fees

13 Nov - 14 Nov

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A reception area with two counters, a patterned wall, and a wooden floor.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

18. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

Richard

₹11,216

₹12,912 total

includes taxes & fees

7 Nov - 8 Nov

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A garden with a water feature, rocks, and yellow umbrellas.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 0.6 km from Mayo Clinic

Deanna

₹10,841

₹12,480 total

includes taxes & fees

23 Oct - 24 Oct

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

A hotel reception desk with a modern design, a clock, and a digital screen.

A modern lounge area with a curved sofa, a round table, and a seating area with chairs.

A modern hotel room with a large bed, two bedside tables, and built-in lighting.

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park, 1.1 km from Mayo Clinic

Jackie

₹10,594

₹12,196 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,000 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 748 reviews	View
The Berkman	9.6 Exceptional 450 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 316 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 571 reviews	View

Hotels recommended for families near Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

₹10,157

₹11,693 total

includes taxes & fees

24 Oct - 25 Oct

A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.

A hotel room with a large bed, a desk, a chair, a microwave, and a framed picture on the wall.

A bar area with a long counter, multiple bar stools, and a television mounted above the bar.

A banquet hall with round tables, chairs, chandeliers, and a fireplace.

Kahler Grand Hotel

Downtown Rochester

₹13,433

₹15,465 total

includes taxes & fees

23 Oct - 24 Oct

Brentwood Inn & Suites

Downtown Rochester

₹11,391

₹13,114 total

includes taxes & fees

23 Oct - 24 Oct

Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

₹12,056

₹13,879 total

includes taxes & fees

29 Oct - 30 Oct

A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

A restaurant with a bar area, wooden chairs, and a stone wall.

A reception area with a wooden reception desk, a clock, and a wall-mounted display.

A hotel room with a sofa, two beds, a large window, and a framed artwork on the wall.

Kahler Inn and Suites - Mayo Clinic Area

Downtown Rochester

₹11,951

₹13,759 total

includes taxes & fees

31 Oct - 1 Nov

A modern hotel room with a large window, a sofa set, a dining table, and a lamp.

A rooftop terrace with outdoor seating and a city skyline in the background.

A modern indoor swimming pool with clear water, surrounded by lounge chairs and a seating area with a patterned wall.

A spacious lobby with modern furniture, a staircase, and large windows.

Hilton Rochester Mayo Clinic Area

Downtown Rochester

₹16,864

₹19,414 total

includes taxes & fees

7 Nov - 8 Nov

Aspen Suites

Rochester

₹13,447

₹16,255 total

includes taxes & fees

23 Oct - 24 Oct

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

₹13,005

₹14,972 total

includes taxes & fees

6 Nov - 7 Nov

Top Mayo Clinic Hotel Reviews

Kahler Grand Hotel

10/10 Excellent

"This Hotel has clean rooms with a microwave and small fridge. The front desk staff were pleasant and professional"

TownePlace Suites by Marriott Rochester Mayo Clinic Area

10/10 Excellent

"We enjoyed breakfast. Room was nice layout. Would prefer a shower with a door to prevent draft. Staff was always helpful. The shuttle was excellent, picked us up rapidly when called. Drivers were very friendly. The only reason we might not return would be the room rates which seem to fluctuate."

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Staff were nice. Room was clean. Close enough to Mayo. Quite a few used shuttle from hotel and said it was very convenient."

Hilton Rochester Mayo Clinic Area

10/10 Excellent

"Great location"

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"EVEN is our go-to hotel when visiting Rochester for doctors appointments. It’s close enough to walk and we love the clean modern rooms."

Aspen Select

8/10 Good

"Small area to park in and not easy to get to"

Broadway Plaza, Trademark Collection by Wyndham

10/10 Excellent

"The property had two bathrooms which was a nice surprise. The kitchen had a full size refrigerator, dishwasher, and laundry machine. The room also had a very pleasant air freshener smell and the bathroom had night lights so you didn'thave to turn on the bathroom's big light in during the night. Thank you for making our stay so pleasant."

Hilton Garden Inn Rochester Downtown, MN

10/10 Excellent

"The staff was very helpful. Our room was very clean. Loved how easy it was to get to the Mayo Clinic."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 153 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels should I expect to find near Mayo Clinic?

Expedia has 153 hotels and other accommodation options within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Search Hotels Near Mayo Clinic, Rochester

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Be picky

Check prices for these dates

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Our top choices for Mayo Clinic hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

3. The Berkman

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

5. TownePlace Suites by Marriott Rochester Mayo Clinic Area

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

9. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

11. Econo Lodge Mayo Clinic Area

12. Hyatt House Rochester/Mayo Clinic Area

13. Hampton Inn Rochester-South

14. Aspen Suites

15. Brentwood Inn & Suites

16. Hotel Indigo Rochester – Mayo Clinic Area by IHG

17. Quality Inn & Suites Mayo Clinic Area

18. Hilton Garden Inn Rochester Downtown, MN

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Compare popular hotels close to Mayo Clinic

Hotels recommended for families near Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Kahler Grand Hotel

Brentwood Inn & Suites

Hyatt House Rochester/Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

Hilton Rochester Mayo Clinic Area

Aspen Suites

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Top Mayo Clinic Hotel Reviews

Kahler Grand Hotel

TownePlace Suites by Marriott Rochester Mayo Clinic Area

AmericInn by Wyndham Rochester Near Mayo Clinic

Hilton Rochester Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Aspen Select

Broadway Plaza, Trademark Collection by Wyndham

Hilton Garden Inn Rochester Downtown, MN

Frequently asked questions

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