Search Luxury Hotels in Santee

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee Luxury Hotels

No exact matches found, but these alternatives could be just right

Recommended hotels in Santee

Property amenity
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 star property
Santee
9.8 out of 10, Exceptional, (1004)
"Clean, friendly staff, new, good value"
United States
Robert
The price is ₹10,900
₹12,099 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites by Marriott Santee
Seasonal outdoor pool
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 star property
Santee
9.6 out of 10, Exceptional, (1000)
"Rooms are clean, friendly staff and easy to get off and back on the highway. "
United States
Michelle
The price is ₹10,089
₹11,199 total
includes taxes & fees
17 Dec - 18 Dec
Hampton Inn Santee-I-95
Exterior
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 star property
Santee
8.8 out of 10, Excellent, (1000)
"Nice rooms and very good breakfast items."
United States
Stephen
The price is ₹10,643
₹11,814 total
includes taxes & fees
16 Dec - 17 Dec
Best Western Plus Santee Inn
Exterior
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3.0 star property
Santee
8.2 out of 10, Very good, (972)
"Was able to walk to convenience store and other dinning alternatives. Safe secure building"
United States
Joan
The price is ₹9,368
₹10,399 total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Santee by IHG
Lobby
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 star property
Santee
8.0 out of 10, Very good, (1002)
"Close to the highway with a safe location."
United States
Benjamin
The price is ₹8,882
₹9,859 total
includes taxes & fees
15 Dec - 16 Dec
Comfort Inn & Suites Santee
Lobby
Tru By Hilton Santee

Tru By Hilton Santee

2.5 star property
Santee
9.2 out of 10, Wonderful, (631)
"Nice place to stay"
Canada
Tanya
The price is ₹9,080
₹10,079 total
includes taxes & fees
8 Jan - 9 Jan 2026
Tru By Hilton Santee
Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 star property
Santee
8.0 out of 10, Very good, (1409)
"The best stay"
United States
Terez
The price is ₹7,206
₹7,998 total
includes taxes & fees
11 Dec - 12 Dec
Baymont by Wyndham Santee
Exterior
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2.0 star property
Santee
7.0 out of 10, Good, (675)
"The room was very nice. It was newly renovated and I loved the upgrade. The beds were comfortable and warm. We didn’t eat breakfast because we were meeting someone for breakfast. "
United States
Alice
The price is ₹5,495
₹6,099 total
includes taxes & fees
5 Jan - 6 Jan 2026
Travelodge by Wyndham Santee
Lobby
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2.0 star property
Santee
6.8 out of 10, (440)
"The staff was very friendly and helpful. Room was clean and beds were so comfortable. "
United States
Kathy
The price is ₹6,306
₹6,999 total
includes taxes & fees
11 Dec - 12 Dec
Super 8 by Wyndham Santee
Lobby
Red Roof Inn Santee

Red Roof Inn Santee

2.0 star property
Santee
6.6 out of 10, (637)
"It's a good stop for the price "
United States
Martin
The price is ₹6,305
₹6,998 total
includes taxes & fees
11 Dec - 12 Dec
Red Roof Inn Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santee Hotel Reviews

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

10/10 Excellent
"We like this location and have stayed here several times. We travel with our service dogs and this location has a nice outdoor area that is well lit at night for potty breaks. ***PLEASE NOTE…this hotel is NOT pet friendly. We will often seek out pet friendly facilities as a first option when we travel and this location comes up in the search. However upon arrival there’s a sign on the door that reads service animals only. I only mention it as a heads up. Our first stay we had prepaid for our room and if our dogs were not service animals we would have been in a bad situation as it was late when we arrived and would have had no place to go. Otherwise this is a great location and place to stay for us on our travels up and down I-95!"
Monica 1-night trip
Posted 9 days ago
Comfort Inn & Suites Santee

Explore a world of travel with Expedia

Frequently asked questions

Are you looking for a luxury hotel for your stay in Santee?
Let Expedia help you arrange your flight to Columbia, SC (CAE-Columbia Metropolitan) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa or several swimming pools, Expedia can help you find the best luxury hotel experience that Santee offers. During your visit, you might want to enjoy the restaurants and coffee shops which Santee is known for.
When can I expect good weather in Santee?
Planning for the weather is an important factor for making your trip to Santee a success, especially when you're splurging. The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.
What's there to see and do in Santee?
Enjoy all that Santee has to offer and visit Santee Cooper Country Club, Santee National Golf Club and Santee State Park. If you have a little extra time during your trip, you might want to make a stop at Lake Marion and Santee Town Hall.