All Hotels by Best Western in Otay Mesa West - 2026 Updated Prices

A marina with boats docked, a city skyline with high-rise buildings, and a sunset with pink and orange clouds.

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Our top choices for Otay Mesa West Best Western

A hotel lobby with a 'Lobby' sign, palm trees, and a sunset sky.

1. Best Western Seven Seas

Mission Valley

James

₹9,132 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with a large bed, a desk with a chair, a nightstand, a mirror, and a blue-striped carpet.

2. Best Western Chula Vista/Otay Valley Hotel

Otay

Edna

₹11,347 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a desk, a chair, and a large window with a view of the outdoors.

3. Best Western Yacht Harbor Hotel

Point Loma

Elizabeth

₹12,286 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with a large bed, a TV, a desk with a lamp, and a bookshelf.

4. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Mission Valley

Antonia

₹13,804 total

includes taxes & fees

10 Nov - 11 Nov

A modern reception area with a large arched window, a reception desk, a blue sofa, and a round wooden table.

5. Best Western San Diego Pacific Beach/Mission Bay

Bay Park

Gabriel

₹11,304 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

6. Best Western Americana Inn

San Ysidro

Erika

₹11,187 total

includes taxes & fees

22 Nov - 23 Nov

A pool area with lounge chairs and a hot tub, surrounded by a multi-level building with balconies.

7. Best Western Santee Lodge

Santee

Salvador

₹10,714 total

includes taxes & fees

12 Nov - 13 Nov

An outdoor patio with wicker furniture, a wooden pergola, and potted plants.

8. Best Western Downtown San Diego

Downtown San Diego

Jackelin

₹11,319 total

includes taxes & fees

11 Nov - 12 Nov

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Top Otay Mesa West Hotel Reviews

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent

"Very clean"

California Suites Hotel

8/10 Good

"Second time staying here , this time around check in was not pleasant , we arrived at check in like at 10pm and the employee was not very welcoming, first of all he was not nice and was very impatient, i first asked where are we staying? since last time we got a really smelly room of cigarettes , his response was where? (Like i would remember the initial room) i would of said they switched us but the talk wasn't pleasant , and rushed. I also needed my plates to have on file which of course i don't know by heart but my husband was going to move our car to the handicapped spot so i told him i would get it from him , he was impatient and just said to call the front desk and give it to them . i wrote the color ,make , and model. We were tired and just wanted to check in but he made it uncomfortable. Our first time here was great which is why we went back, now i don't know if we will be back , since we come for a yearly festival this place is very convenient as it os only 15 minutes away :/"

Handlery Hotel

8/10 Good

"The beds were comfortable and the room overall was good. There was an almost mothball smell to the room, which was a little off putting at first, and the door jam looked like it had been scratched up and chipped away at, which did make me question the security of them room. But, I was pleasantly surprised at the comfort of the beds. The staff was helpful. The parking lot required having to scan in and out of the lot with the room key, which felt a bit clunky. It would have been better with an auto arm upon exit."

Find out more about Otay Mesa West

Otay Mesa West

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Otay Mesa West hotels information

Number of reviews	2,327
Accommodation	7,116 hotels
Lowest Price	₹9,132
Highest Price	₹13,804

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Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Otay Mesa West Best Western

1. Best Western Seven Seas

2. Best Western Chula Vista/Otay Valley Hotel

3. Best Western Yacht Harbor Hotel

4. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

5. Best Western San Diego Pacific Beach/Mission Bay

6. Best Western Americana Inn

7. Best Western Santee Lodge

8. Best Western Downtown San Diego

Top Otay Mesa West Hotel Reviews

The Alcala Hotel Mission Valley/Seaworld

Kings Inn San Diego

Hyatt Regency Mission Bay Spa and Marina

California Suites Hotel

Hard Rock Hotel San Diego

The Sofia Hotel

Wyndham San Diego Bayside

Handlery Hotel

Bay Club Hotel & Marina

Find out more about Otay Mesa West

Otay Mesa West

Otay Mesa West hotels information

Explore a world of travel with Expedia

Search Hotels by Best Western in Otay Mesa West from ₹9,132

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Otay Mesa West Best Western

1. Best Western Seven Seas

2. Best Western Chula Vista/Otay Valley Hotel

3. Best Western Yacht Harbor Hotel

4. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

5. Best Western San Diego Pacific Beach/Mission Bay

6. Best Western Americana Inn

7. Best Western Santee Lodge

8. Best Western Downtown San Diego

Top Otay Mesa West Hotel Reviews

The Alcala Hotel Mission Valley/Seaworld

Find out more about Otay Mesa West

Otay Mesa West

Otay Mesa West hotels information

Explore a world of travel with Expedia