𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Defiance (2026)

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

A hotel lobby with a reception desk, seating area, and a large potted plant.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Tim

₹7,647

₹9,020 total

includes taxes & fees

2 Nov - 3 Nov

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

2. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

₹12,382

₹14,532 total

includes taxes & fees

21 Oct - 22 Oct

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

A modern hotel room with a desk, chair, and a large mirror.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

₹8,996

₹10,611 total

includes taxes & fees

15 Oct - 16 Oct

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

A hotel room with a desk, chair, sofa, and a window with curtains.

4. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

₹8,996

₹10,611 total

includes taxes & fees

18 Oct - 19 Oct

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A gym with a treadmill, elliptical, stationary bike, and a rack of dumbbells.

A hotel with a brick facade, multiple parking spaces, and a grassy area in the foreground.

A hotel room with two beds, a desk, a mirror, and a wardrobe.

5. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Brenda

₹8,140

₹9,811 total

includes taxes & fees

19 Oct - 20 Oct

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

6. Residence Inn by Marriott O'Fallon

O'Fallon

Rianna

₹12,672

₹14,947 total

includes taxes & fees

30 Oct - 31 Oct

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A spacious living area with a staircase, a large painting, and a chandelier.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

7. The Wildwood Hotel

Wildwood

Ryan

₹8,001

₹9,320 total

includes taxes & fees

9 Nov - 10 Nov

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

8. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

₹10,471

₹12,416 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio area with wicker furniture and a central fire feature.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

9. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

₹11,231

₹13,069 total

includes taxes & fees

18 Oct - 19 Oct

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

10. Hyatt Place St. Louis/Chesterfield

Chesterfield

Debbie

₹11,666

₹13,531 total

includes taxes & fees

18 Oct - 19 Oct

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

11. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

₹11,429

₹13,299 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a central round table, two sofas, and a chandelier.

A buffet setup with various food items and a decorative vase of flowers.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

12. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Chasity

₹12,575

₹14,585 total

includes taxes & fees

18 Oct - 19 Oct

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A coffee station with two coffee machines and a display of coffee pods and cups.

A Holiday Inn Express & Suites building with a brick facade, a covered entrance, and a numbered address.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

13. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Terry

₹10,641

₹12,382 total

includes taxes & fees

18 Oct - 19 Oct

Two people in a swimming pool with colorful inflatable rings.

A buffet counter with a variety of food items, including pastries and beverages, and a person serving.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

14. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

₹12,285

₹14,311 total

includes taxes & fees

9 Nov - 10 Nov

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

15. Comfort Inn Near Six Flags St. Louis

Pacific

Gail

₹8,712

₹9,973 total

includes taxes & fees

9 Nov - 10 Nov

An outdoor patio with a built-in grill, seating area, and stone walls.

A multi-story hotel with a parking lot in front.

A spacious lounge area with a stone fireplace, comfortable seating, and a large TV screen.

A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.

16. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

Chelsea

₹18,283

₹21,389 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A hotel room with a bathroom, a bed, a nightstand, and a window.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

17. Quality Inn Near Six Flags St. Louis

Pacific

Chantelle

₹8,666

₹9,922 total

includes taxes & fees

9 Nov - 10 Nov

A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

An indoor swimming pool with a clear water area, a shallow end, and a tiled deck surrounding the pool. There are lounge chairs and tables on the deck, and a sign indicating a maximum capacity of 62.

A snack display area with various chips and snacks, a refrigerated section, and a wall with a 'Treats' sign.

A Hampton Inn with a brick facade, outdoor seating area, and a clear sky.

18. Hampton Inn St. Louis Wentzville

Wentzville

Jill

₹13,896

₹15,765 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

A hotel room with orange furniture, a glass coffee table, a dining area with a table and chairs, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, a mirror, and a wardrobe.

A large, multi-story hotel with the name "Doubletree by Hilton" prominently displayed on the facade.

19. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

Saranne

₹13,406

₹15,549 total

includes taxes & fees

30 Oct - 31 Oct

A hotel reception area with a counter, coffee machines, a refrigerated display, and artwork on the wall.

A reception desk with a wooden finish, a clock, and a sign for Marriott Bonvoy.

An indoor swimming pool with clear water, a diving board, and a seating area with tables and chairs.

A hotel room with a bed, desk, TV, and a view of the outdoors.

20. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Chesterfield

Charles

₹10,360

₹12,017 total

includes taxes & fees

25 Oct - 26 Oct

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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

10/10 Excellent

"Great stay always at Drury"

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"We really enjoyed our stay. The room was very clean. The staff were very pleasant and cheerful. The day we were leaving my husband went to get breakfast. The staff said they were not open yet, but told him he could have a tray and take the food to his room. Great place to stay!!"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Last minute, short stay but well worth it. Very clean and comfortable. Good breakfast."

The Wildwood Hotel

10/10 Excellent

"The room was super clean and the jacuzzi was such a fun touch!"

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"Nice stay overall"

La Quinta Inn & Suites by Wyndham St. Louis Westport

10/10 Excellent

"Good Customer Services thanks"

Hyatt Place St. Louis/Chesterfield

10/10 Excellent

"What a wonderful spot! The breakfast was delicious and offered plenty of variety. No matter their role, every staff member was super friendly."

Ameristar Casino Resort and Spa

8/10 Good

"Wonderful stay for a small bachelorette party. Had a wonderful time!"

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

8/10 Good

"Hotel is in a safe, convenient location. NO elevator, but there was an entrance with no steps on the first level. The hallway is a little grody but the room was very clean and arranged in a very convenient way. Lots of space to set things out to organize. Full kitchen but no utensils or cooking pans or dishes. I suppose they would be stolen if they were provided. I did not need them anyway. No ice machine, but ice trays to make your own ice in the freezer. Nice TV with lots of channels. Comfortable bed but lumpy pillow. Nice shower and bathroom. Basically it was perfect for my purposes as I was attending a meeting just down the street at a more expensive hotel. Families do live there and there was more noise in the hall than some would probably like. I ignored it. The office does not open until 9 in the morning and I had to be at my meeting before that time on the day of checkout. So, I had to return in the afternoon as I wanted my checkout paper. The staff was very nice and very helpful."

More cheap stays in Defiance

Quality Inn Foristell

12 Highway W Foristell MO

₹7,672

₹8,666 total

9 Nov - 10 Nov

includes taxes & fees

8.2/10 Very good! (1,004 reviews)

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

₹7,647

₹9,020 total

2 Nov - 3 Nov

includes taxes & fees

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

₹8,177

₹9,399 total

18 Oct - 19 Oct

includes taxes & fees

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

₹9,123

₹10,485 total

18 Oct - 19 Oct

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

₹11,481

₹13,194 total

25 Oct - 26 Oct

includes taxes & fees

8.2/10 Very good! (1,007 reviews)

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

₹12,277

₹14,109 total

1 Nov - 2 Nov

includes taxes & fees

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?

Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.

How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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Book Hotels in Defiance on Expedia.com

Defiance Hotels from ₹7,184

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Defiance hotels

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

2. TownePlace Suites by Marriott St. Louis Chesterfield

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

4. Staybridge Suites O'Fallon Chesterfield by IHG

5. Comfort Inn & Suites Chesterfield - St. Louis

6. Residence Inn by Marriott O'Fallon

7. The Wildwood Hotel

8. Hilton Garden Inn St. Louis/O'Fallon MO

9. Courtyard by Marriott St. Louis Chesterfield

10. Hyatt Place St. Louis/Chesterfield

11. Hampton Inn & Suites St. Louis/Chesterfield

12. Drury Plaza Hotel St. Louis Chesterfield

13. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

14. Holiday Inn St. Louis West Six Flags by IHG

15. Comfort Inn Near Six Flags St. Louis

16. Residence Inn by Marriott St. Louis Chesterfield

17. Quality Inn Near Six Flags St. Louis

18. Hampton Inn St. Louis Wentzville

19. DoubleTree by Hilton Hotel St. Louis - Chesterfield

20. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Sugar Creek Winery

Historic Daniel Boone Home and Heritage Center

Broemmelsiek Park

Yellow Farmhouse Winery

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

Drury Plaza Hotel St. Louis Chesterfield

Hampton Inn St. Charles St. Peters

The Wildwood Hotel

Drury Plaza Hotel St. Louis Creve Coeur

La Quinta Inn & Suites by Wyndham St. Louis Westport

Hyatt Place St. Louis/Chesterfield

Ameristar Casino Resort and Spa

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

More cheap stays in Defiance

Quality Inn Foristell

Sleep Inn & Suites O'Fallon MO - Technology Drive

Country Inn & Suites by Radisson, St. Peters, MO

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

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