Photo by Michelle Hendrix
Search Historic Hotels in Upstate South Carolina
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Upstate South Carolina Historic Hotels
Top Upstate South Carolina Historic Hotels
Holiday Inn Express & Suites Clemson by IHG
Clemson
8.8 out of 10, Excellent, (950)
"Had a great stay at this hotel. Conveniently located near restaurants. "
Kelly
The price is ₹10,619
₹11,787 total
includes taxes & fees
2 Jan - 3 Jan 2026
Pettigru Place Bed & Breakfast
Greenville Downtown
10.0 out of 10, Exceptional, (124)
"One of my favorite places to stay in Greenville. It is such a quaint bed and breakfast despite how close it is to downtown. Excellent service and amazing accommodations. "
Lendell
The price is ₹18,718
₹20,590 total
includes taxes & fees
4 Jan - 5 Jan 2026
Inn on the Square, an Ascend Collection Hotel
Uptown Greenwood
9.2 out of 10, Wonderful, (707)
"It was a very clean and beautiful lace to stay. We were there for our honeymoon "
Tracy
The price is ₹9,830
₹10,911 total
includes taxes & fees
4 Jan - 5 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Upstate South Carolina Hotel Reviews
Drury Inn & Suites Greenville
10/10 Excellent
Explore a world of travel with Expedia
Nearby Cities
Choose Your Upstate South Carolina Hotel Style
- Business Hotels in Upstate South Carolina
- Cheap Hotels in Upstate South Carolina
- Family-Friendly Hotels in Upstate South Carolina
- Golf Hotels in Upstate South Carolina
- Hotels Suites in Upstate South Carolina
- Hotels near Museums in Upstate South Carolina
- Hotels with Air Conditioning in Upstate South Carolina
- Hotels with Airport Transfers in Upstate South Carolina
- Hotels with Breakfast in Upstate South Carolina
- Hotels with Connecting Rooms in Upstate South Carolina
- Hotels with Entertainment in Upstate South Carolina
- Hotels with Gym in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Hotels with Indoor Pools in Upstate South Carolina
- Hotels with Laundry Service in Upstate South Carolina
- Hotels with Parking in Upstate South Carolina
- Hotels with Parking in Upstate South Carolina
- Hotels with Restaurant in Upstate South Carolina
- Hotels with Room Service in Upstate South Carolina
- Hotels with Swimming Pool in Upstate South Carolina
- Hotels with Views in Upstate South Carolina
- Hotels with Wifi in Upstate South Carolina
- Hotels with a Bar in Upstate South Carolina
- Hotels with smoking rooms in Upstate South Carolina
- Lakeside Hotels in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Pet-Friendly Hotels in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Shopping Hotels in Upstate South Carolina
- Spa Hotels in Upstate South Carolina
- Sports Hotels in Upstate South Carolina
- Wedding Hotels in Upstate South Carolina
More accommodation types in Upstate South Carolina
- Holiday Homes in South Carolina
- Condo Rentals in South Carolina
- Apartments in South Carolina
- Cottages in South Carolina
- Villas in South Carolina
- Motels in South Carolina
- Aparthotels in South Carolina
- B&B in South Carolina
- Resorts in South Carolina
- Guest Houses in South Carolina
- Condo Resorts in South Carolina
- Cabin Rentals in South Carolina
- Inns in South Carolina
- Town Houses in South Carolina
- Lodges in South Carolina
- Chalets in South Carolina
- Country Houses in South Carolina
- Houseboats in South Carolina
Hotels near popular Upstate South Carolina Attractions
- Hotels near Clemson University
- Hotels near Bon Secours Wellness Arena
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Memorial Stadium
- Hotels near Falls Park on the Reedy
- Hotels near Greenville Convention Center
- Hotels near Lake Keowee
- Hotels near Lake Jocassee
- Hotels near Fred W. Symmes Chapel
Hotels in Upstate South Carolina by Star Rating
Explore more hotels
- Hyatt Place Greenville/Haywood
- La Quinta Inn & Suites by Wyndham Greenville Haywood
- Embassy Suites by Hilton Greenville Downtown Riverplace
- The Westin Poinsett Greenville
- Drury Inn & Suites Greenville
- Best Western Plus Clemson Hotel & Conference Center
- Courtyard by Marriott Greenville Haywood Mall
- DoubleTree by Hilton Greenville Woodruff Road
- Aloft Greenville Downtown
- Spartanburg Marriott
- Comfort Suites At WestGate Mall
- The Shepherd Hotel Downtown Clemson
- Comfort Inn & Suites Clemson - University Area
- MainStay Suites Greenville Airport
- Tru by Hilton Spartanburg
- Comfort Inn & Suites Greer - Greenville
- Best Western Plus Greenville South
- Inn @ Clemson
More ways to book
Expedia's Latest Trends
Hotels
Flights