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Our top choices for Upstate South Carolina hotels

Spa

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Terri

₹9,966 total

includes taxes & fees

9 Aug - 10 Aug

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Angela

₹10,289 total

includes taxes & fees

9 Aug - 10 Aug

3. Drury Inn & Suites Greenville

Greenville

Mark

₹12,125 total

includes taxes & fees

12 Aug - 13 Aug

4. Comfort Suites Greenville Airport

Greenville

Chandler

₹11,161 total

includes taxes & fees

24 Aug - 25 Aug

5. Courtyard by Marriott Greenville Mauldin

Greenville

sarah

₹11,493 total

includes taxes & fees

9 Aug - 10 Aug

6. Hampton Inn & Suites Greenville Airport, SC

Greenville

Kristina

₹11,970 total

includes taxes & fees

16 Aug - 17 Aug

Egyptian cotton sheets, premium bedding, pillow-top beds, in-room safe

7. Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

₹7,708 total

includes taxes & fees

2 Aug - 3 Aug

8. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Jessica

₹8,955 total

includes taxes & fees

16 Aug - 17 Aug

9. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

₹12,019 total

includes taxes & fees

9 Aug - 10 Aug

10. Holiday Inn Express & Suites Greenville S- Piedmont by IHG

Piedmont

Kristin

₹10,228 total

includes taxes & fees

16 Aug - 17 Aug

11. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Robert

₹13,044 total

includes taxes & fees

16 Aug - 17 Aug

12. Hyatt Place Greenville Downtown

Greenville Downtown

Mark

₹14,678 total

includes taxes & fees

2 Aug - 3 Aug

13. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Anne

₹11,047 total

includes taxes & fees

16 Aug - 17 Aug

14. Comfort Inn Greenville - Haywood Mall

Greenville

Brittney

₹10,205 total

includes taxes & fees

16 Aug - 17 Aug

15. Wingate by Wyndham - Greenville-Airport

Greenville

Meridy

₹8,445 total

includes taxes & fees

23 Aug - 24 Aug

16. Hampton Inn Greer Greenville, SC

Greer

Teresa

₹14,524 total

includes taxes & fees

1 Aug - 2 Aug

17. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Jennifer

₹10,432 total

includes taxes & fees

2 Aug - 3 Aug

18. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Christion

₹14,567 total

includes taxes & fees

9 Aug - 10 Aug

19. Hilton Garden Inn Greenville

Greenville

Robert

₹10,598 total

includes taxes & fees

9 Aug - 10 Aug

20. Holiday Inn Express & Suites Greenville - Taylors by IHG

Greenville

Elizabeth

₹10,136 total

includes taxes & fees

2 Aug - 3 Aug

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Holiday Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-sized fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"Very good check in instructions. Very roomy and very quiet. Much more relaxing than a hotel room. Worth every penny."

Aparthotel

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Aloft by Marriott Greenville Downtown

10/10 Excellent

"The communication prior to arriving was excellent and a nice surprise. Upon arrival we were greeted by a smiling staff that explained some important local information we were unaware of. The hotel and our room was great. We enjoyed an evening at the WXYZ bar and had a great time talking with the staff. Can’t really beat the location either. Wife and I agreed we would definitely stay here again on our next visit."

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"The staff was helpful. Good breakfast. Comforter had a stain…which was not great. Found a towel hook in bathroom on the floor in the morning because it had been put in the wall so many times the wall was coming apart. The toilet seat was coming off. I let staff know about the problems when I checked out and they appreciated it. Seemed like the room/walls need a deep cleaning/updating. However, it was still fine, quiet, and comfortable."

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"I ended up staying for an extra night because my flight was delayed. Both staff that checked me in each time were top notch. Very professional and polite. Asked us about our trip and thanked us for staying there. Best service I could ever expect. Thank you."