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Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

₹7,958 total

includes taxes & fees

1 Nov - 2 Nov

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Caitlin

₹10,524 total

includes taxes & fees

23 Nov - 24 Nov

A modern indoor fire feature with a stone border, surrounded by seating areas and a glass wall in the background.

3. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Deborah

₹15,262 total

includes taxes & fees

22 Nov - 23 Nov

A hotel patio with outdoor seating, stone pillars, and a modern building in the background.

4. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jamie

₹11,975 total

includes taxes & fees

24 Nov - 25 Nov

A spacious lobby with a modern design, featuring a reception desk, seating area with sofas and armchairs, and a large chandelier.

5. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Taleigha

₹9,773 total

includes taxes & fees

1 Nov - 2 Nov

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

6. Drury Inn & Suites Greenville

Greenville

Jamie

₹11,902 total

includes taxes & fees

8 Nov - 9 Nov

A modern hotel room with a large bed, a desk, and a kitchenette.

7. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Maclin

₹7,457 total

includes taxes & fees

12 Nov - 13 Nov

A multi-story hotel with a stone facade, large windows, and outdoor seating areas.

8. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Cindy

₹15,830 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with modern furniture, a chandelier, and potted plants.

9. Hilton Greenville

Greenville

William

₹11,409 total

includes taxes & fees

22 Nov - 23 Nov

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

10. Tru by Hilton Greenville Woodruff Road

Greenville

Amy

₹11,437 total

includes taxes & fees

23 Nov - 24 Nov

A hotel lobby with round tables and chairs, a TV mounted on the wall, and a reception desk.

11. Hyatt Place Greenville Downtown

Greenville Downtown

Tamara

₹14,560 total

includes taxes & fees

22 Nov - 23 Nov

A covered outdoor area with a grill and seating, surrounded by brick walls and windows.

12. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Cyrus

₹14,592 total

includes taxes & fees

24 Nov - 25 Nov

A Comfort Inn hotel with a stone facade, a clear sign indicating a 12'6" clearance, and a well-lit entrance.

13. Comfort Inn Greenville - Haywood Mall

Greenville

Paul

₹9,214 total

includes taxes & fees

8 Nov - 9 Nov

A Holiday Inn Express & Suites with a covered entrance and a clear sky.

14. Holiday Inn Express & Suites Greenville-I-85 & Woodruff Rd by IHG

Greenville

Kyriaki

₹12,834 total

includes taxes & fees

26 Nov - 27 Nov

A dining area with a wooden table, chairs, and a vase of white flowers.

15. Hotel Hartness

Greenville

Nicole

₹20,868 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

16. Hilton Garden Inn Greenville

Greenville

Valerie

₹9,640 total

includes taxes & fees

22 Nov - 23 Nov

A modern lobby with a reception desk, seating area, and a kitchen in the background.

17. Courtyard by Marriott Greenville Downtown

Greenville Downtown

Ray

₹15,393 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.

18. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Joseph

₹10,966 total

includes taxes & fees

5 Nov - 6 Nov

A modern hotel lobby with a bar area, seating, and a reception desk.

19. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Rick

₹10,548 total

includes taxes & fees

1 Nov - 2 Nov

A balcony with two wicker chairs and a small table, overlooking a courtyard with a building in the background.

20. Courtyard by Marriott Greenville Haywood Mall

Greenville

alejandro

₹11,311 total

includes taxes & fees

23 Nov - 24 Nov

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Holiday Rentals in Upstate South Carolina

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"The kitchen was nice and came with basic utensils which was helpful"

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location, convenient!"

Aparthotel

A modern building with outdoor seating and a garden.

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Apartment

A spacious living room with a stone fireplace, wooden beams, and a chandelier.

Landing Apartments Greer - Sugar Creek

Greer

"The apartment was clean. Excellent value for stay. Amenities were great. Will book again!"

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"My wife and I enjoyed our stay here. 10/10 experience."

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A spacious living room with a dining area, a leather sofa, a TV, and artwork on the walls.

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Cottage

A cozy bedroom with a bed, a nightstand, a lamp, a small table, a window, and a Christmas tree.

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Apartment

A swimming pool with a view of a lake and docked boats.

Lake Keowee Condo: Resort Pools & Lake Access!

Salem

"Wow!! Absolutely beautiful property. Recent remodel with beautiful and very tasteful design. Amazingly clean, organized and tidy. We are from Denver and did not have exposure to Lake Keowee. The lake was beautiful with great walking trails on the property. Special and spectacular spot! We will definitely go back. This is a gated community. Super comfortable king beds and nice linens."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina