Compare and book 4 Star hotels in Upstate South Carolina, South Carolina
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Top Upstate South Carolina 4 Star Hotels

The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson

Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection

The Westin Poinsett Greenville
The Westin Poinsett Greenville

Mint House Greenville - Downtown
Mint House Greenville - Downtown

Hotel Hartness
Hotel Hartness

Greenville Marriott
Greenville Marriott

The Abernathy of Clemson
The Abernathy of Clemson

Barsala At The American Spinning Mill Apartments
Barsala At The American Spinning Mill Apartments
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

Find out more about Upstate South Carolina
Find out more about Upstate South Carolina
Take Your Pick of 4 Star Hotels in Upstate South Carolina
The get-go of any holiday starts with choosing a great spot. Upstate South Carolina has been a popular destination with guests because it offers so much to do and see. But, "location, location, location" applies to more than just what city where your plane lands. Now that you have a feel for the town, it's time you to get to know your new digs.
Accommodations as Picturesque as Upstate South Carolina
Search Expedia.com.sg for the right 4 Star Upstate South Carolina Hotel to suit your fancy. Plenty of these people wrote tips to help you select the accommodation that is the right fit for your holiday.You'll be more than glad to get back to your resort every night. Upstate South Carolina has dozens of good options in the 4-star hotel range that create the ideal getaway.
A stay at one of these lodgings ensure that whether you are just relaxing after a day of checking out Upstate South Carolina or you are ready to lie down for the night, you'll be as comfortable as possible. You won't go without a thing during your stay at one of these accommodations. Visitors have consistently given them high marks for their attentive service. It's no surprise that loads of guests recommend it.
Reserve a 4-Star Hotel in Upstate South Carolina Today!
Your trip to Upstate South Carolina should be one that you'll reminisce over for years to come, and booking a 4-star hotel will help create memories that are incredible. Make sure to make a reservation soon. With so few hotels, and plenty of people desiring to vacation in Upstate South Carolina, you may miss out on your perfect hotel.
Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Mint House Greenville - Downtown
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Upstate South Carolina by Star Rating
Accommodation near Upstate South Carolina attractions
- Hotels near Clemson University
- Hotels near Lake Keowee
- Hotels near Falls Park on the Reedy
- Hotels near Lake Jocassee
- Hotels near Bon Secours Wellness Arena
- Hotels near Greenville Convention Center
- Hotels near Fred W. Symmes Chapel
- Hotels near Bob Jones University
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Memorial Stadium
- Hotels near WestGate Mall
Choose Your Upstate South Carolina Hotel Style
- Business Hotels in Upstate South Carolina
- Cheap Hotels in Upstate South Carolina
- Family-Friendly Hotels in Upstate South Carolina
- Golf Hotels in Upstate South Carolina
- Historic Hotels in Upstate South Carolina
- Hotels Suites in Upstate South Carolina
- Hotels near Museums in Upstate South Carolina
- Hotels with Air Conditioning in Upstate South Carolina
- Hotels with Airport Transfers in Upstate South Carolina
- Hotels with Breakfast in Upstate South Carolina
- Hotels with Connecting Rooms in Upstate South Carolina
- Hotels with Entertainment in Upstate South Carolina
- Hotels with Gym in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Hotels with Laundry Service in Upstate South Carolina
- Hotels with Parking in Upstate South Carolina
- Hotels with Parking in Upstate South Carolina
- Hotels with Restaurant in Upstate South Carolina
- Hotels with Room Service in Upstate South Carolina
- Hotels with Swimming Pool in Upstate South Carolina
- Hotels with Views in Upstate South Carolina
- Hotels with Wifi in Upstate South Carolina
- Hotels with a Bar in Upstate South Carolina
- Hotels with smoking rooms in Upstate South Carolina
- Lakeside Hotels in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Pet-Friendly Hotels in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Shopping Hotels in Upstate South Carolina
- Spa Hotels in Upstate South Carolina
- Sports Hotels in Upstate South Carolina
- Wedding Hotels in Upstate South Carolina
More accommodation types in Upstate South Carolina
- Cottages in Upstate South Carolina
- Motels in Upstate South Carolina
- Apartments in Upstate South Carolina
- Aparthotels in Upstate South Carolina
- B&B in Upstate South Carolina
- Holiday Homes in Upstate South Carolina
- Cabin Rentals in Upstate South Carolina
- Condo Rentals in Upstate South Carolina
- Resorts in Upstate South Carolina
- Lodges in Upstate South Carolina
- Villas in Upstate South Carolina
Explore more hotels
- Wingate by Wyndham - Greenville-Airport
- Hyatt Place Greenville/Haywood
- Embassy Suites Greenville Golf Resort & Conference Center
- Mint House Greenville - Downtown
- Hyatt Place Greenville Downtown
- Midtown Suites-Greenville
- Days Inn by Wyndham Greenville
- Best Western Greenville Airport Inn
- Horizon Inn & Suites
- ECHO Suites Extended Stay by Wyndham Spartanburg
- Days Inn by Wyndham Spartanburg Waccamaw
- Spartanburg Marriott
- Comfort Suites At WestGate Mall
- Best Western Spartanburg Northwest
- Holiday Inn Express & Suites Greenville Airport by IHG
- Microtel Inn & Suites by Wyndham Anderson/Clemson
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