La Quinta Inn & Suites Hotels in Southeast Missouri
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United States of America
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A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Search Hotels by La Quinta Inn & Suites in Southeast Missouri from ₹7,514

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Our top choices for Southeast Missouri La Quinta Inn & Suites

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a landscaped entrance area.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

An outdoor patio with tables and chairs, a stone wall, and large windows.

A hotel room with two beds, a nightstand, a lamp, and a chair.

1. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property

Jackson

8.8 out of 10, Excellent, (897 reviews)

8.8/10

Excellent

(897 reviews)

"Very clean and every one very nice and helpful"

richard

The price is ₹7,514

₹7,514

₹8,132 total

includes taxes & fees

16 Nov - 17 Nov

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

A modern hotel with a prominent 'La Quinta' sign, large windows, and a well-lit entrance.

A swimming pool with lounge chairs and a view of the night sky.

2. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3.0 star property

Festus

7.8 out of 10, Good, (1,001 reviews)

7.8/10

Good

(1,001 reviews)

"Nice breakfast. The hotel is a little worn but clean and comfortable."

Julie

The price is ₹7,914

₹7,914

₹9,049 total

includes taxes & fees

16 Nov - 17 Nov

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Top Southeast Missouri Hotel Reviews

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

An indoor swimming pool area with a hot tub, a table with chairs, and a sign warning of no lifeguard on duty.

A spacious dining area with multiple tables and chairs, large windows, and recessed ceiling lights.

A hotel room with a television, a sofa, a yellow ottoman, a desk with a lamp, and a framed picture on the wall.

Drury Inn & Suites St. Louis Arnold

Arnold

10/10 Excellent

Lovely hotel all good

ivan

Reviewed August 1, 2018Reviewed August 1, 2018

Drury Inn & Suites St. Louis Arnold

An indoor swimming pool with a clear view of the outside through large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

A spacious lobby with a reception desk, seating area, and large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

Drury Inn & Suites Poplar Bluff

Poplar Bluff

10/10 Excellent

Just one night, but CeeCee left a lasting impression on us. Lovely lady!

Gary

Reviewed August 26, 2017Reviewed August 26, 2017

Drury Inn & Suites Poplar Bluff

A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

A compact kitchen with a microwave, a coffee maker, a sink, and a small refrigerator.

A reception desk with a 'Welcome to Hampton' sign, a 'Hampton Guarantee' badge, and a 'Hilton Honors' sign.

Hampton Inn Poplar Bluff

Poplar Bluff

10/10 Excellent

Very clean Good breakfast Very helpful staff

heather

Reviewed May 22, 2026Reviewed May 22, 2026

Hampton Inn Poplar Bluff

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A multi-story hotel with a modern facade, a covered entrance, and a parking lot with handicapped-accessible spaces.

A modern conference room with a large table, wooden chairs, and a colorful striped carpet.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

10/10 Excellent

It was wonderful stay and very comfortable sleep

Sarmad

Reviewed September 9, 2023Reviewed September 9, 2023

Fairfield Inn & Suites by Marriott Poplar Bluff

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Search Hotels by La Quinta Inn & Suites in Southeast Missouri from ₹7,514

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Missouri La Quinta Inn & Suites

1. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

2. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites St. Louis Arnold

10/10 Excellent

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