𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southeast Missouri (2026)

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Go beyond your typical stay in Southeast Missouri

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Cottage

Family friendly

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A building with a red awning labeled "Shepherd Mountain Inn."

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

1. Shepherd Mountain Inn

Ironton

Michael

₹11,927

₹13,028 total

includes taxes & fees

13 Oct - 14 Oct

A motel with a covered entrance, a flag, and a phone number.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

2. Madison Inn Lodge

Fredericktown

Bawan

₹8,562

₹9,351 total

includes taxes & fees

13 Oct - 14 Oct

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Abram

₹8,646

₹9,887 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

A hotel lobby with a seating area, a reception desk, and a bar.

A swimming pool with a diving board, pool rules signs, and lounge chairs.

4. Holiday Inn Express & Suites Perryville by IHG

Perryville

Lisa

₹9,770

₹11,184 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

5. Super 8 by Wyndham Farmington

Farmington

Marisa

₹5,756

₹6,582 total

includes taxes & fees

23 Oct - 24 Oct

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

6. Fort Davidson Hotel

Ironton

richard

₹11,608

₹12,679 total

includes taxes & fees

10 Nov - 11 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

A corner market with a refrigerated display case and a pantry area.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

7. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Nancy

₹9,374

₹10,590 total

includes taxes & fees

9 Nov - 10 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A bar area with stools and a counter where a bartender is serving drinks.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

8. EC Reed's Mercantile and Hotel

Marble Hill

Miranda

₹10,171

₹11,071 total

includes taxes & fees

13 Oct - 14 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A gym with cardio equipment, a bench press, and a squat rack.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

9. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

stewart

₹5,262

₹6,018 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a reception desk, seating area, and large windows.

An indoor swimming pool with a clear view of the outside through large windows.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

10. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

₹9,092

₹10,272 total

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

11. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

₹10,607

₹12,129 total

includes taxes & fees

25 Oct - 26 Oct

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

A swimming pool with lounge chairs and a view of the night sky.

A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

A modern hotel with a prominent 'La Quinta' sign, large windows, and a well-lit entrance.

12. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Debra S

₹8,140

₹9,308 total

includes taxes & fees

15 Oct - 16 Oct

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

13. Super 8 by Wyndham Perryville

Perryville

Matthew

₹6,578

₹7,530 total

includes taxes & fees

8 Nov - 9 Nov

A modern kitchen with a central island, built-in appliances, and a view into the dining area.

A reception desk with a modern design, a digital screen, and a sign indicating 'IHG' branding.

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

A hotel room with a bed, a desk, a microwave, a coffee maker, and a TV mounted on the wall.

14. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Zach

₹9,674

₹11,062 total

includes taxes & fees

1 Nov - 2 Nov

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

15. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

₹9,785

₹11,039 total

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.

A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

16. Hampton Inn Farmington

Farmington

Charlie

₹9,538

₹10,907 total

includes taxes & fees

25 Oct - 26 Oct

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A hotel dining area with tables and chairs, a kitchen area, and a flat-screen TV mounted on the wall.

A hotel room with two beds, a desk, a chair, and a window with curtains.

17. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

₹8,184

₹9,624 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a sofa, a small table, a chair, a desk, two lamps, a window with curtains, and a framed picture on the wall.

A hotel room with two beds, a bedside lamp, a bench, a mirror, and a door leading to another room.

A Holiday Inn hotel with a covered entrance, multiple flags, and a brick facade.

18. Holiday Inn Poplar Bluff by IHG

Poplar Bluff

Nathan

₹8,126

₹9,180 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

19. The Riverview

Cape Girardeau

Alyssa

₹9,619

₹10,852 total

includes taxes & fees

15 Oct - 16 Oct

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

20. Drury Inn & Suites Jackson MO

Jackson

Debra S

₹7,738

₹8,181 total

includes taxes & fees

18 Oct - 19 Oct

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Holiday Rentals in Southeast Missouri

Cabin

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

A view through a window with a stone wall and a wooden structure in the background.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with a wooden ceiling, a fireplace, and a television.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A hallway with exposed brick walls, wooden flooring, and a white door.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cabin

A bedroom with a wooden bed, a bench, and a window.

A calm lake with a wooden dock and a forested island in the distance.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

A spacious living area with a kitchen island, dining table, and a television.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

A covered porch with yellow chairs, a bench, and a small table.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A wooden deck with a hot tub, a small table, and a bench.

A rural property with a gravel driveway leading to a house with a porch, surrounded by lush greenery and trees.

A bedroom with a sloped ceiling, a bed with a white and yellow bedspread, a wooden chair, a round rug, and a wooden wall with a window.

A rustic interior with a stone fireplace, wooden furniture, and a cozy seating area.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A living room with a sofa, coffee table, TV stand, and ceiling fan.

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Great stay! Beautiful rooms!"

Super 8 by Wyndham Sikeston/Miner Area

8/10 Good

"It is a clean place, and we enjoyed our stay"

The Riverview

10/10 Excellent

"."

Hampton Inn Poplar Bluff

10/10 Excellent

"Hotel has been recently remodeled. Room was very clean. Staff was so helpful especially Sue who checked us in!"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"The hotel was very clean and nice. The beds were very comfortable. I would stay again"

Motel 6 Poplar Bluff, MO

8/10 Good

"I only stayed here from midnight until 5:30. It was clean, however the bed was very thin and uncomfortable and the heat/ac didn't work correctly which happens sometimes. The thermostat said 75 and it was freezing. It was a good place to crash for a few hours."

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"The room was clean and the staff was very helpful. A great getaway for anyone who likes nature"

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

₹5,262

₹6,018 total

1 Nov - 2 Nov

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

₹6,414

₹7,310 total

1 Nov - 2 Nov

includes taxes & fees

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

₹6,878

₹7,701 total

26 Oct - 27 Oct

includes taxes & fees

8/10 Very good! (1,002 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

₹6,964

₹7,856 total

25 Oct - 26 Oct

includes taxes & fees

9.2/10 Wonderful! (1,003 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

₹6,888

₹8,048 total

1 Nov - 2 Nov

includes taxes & fees

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

₹8,798

₹9,852 total

1 Nov - 2 Nov

includes taxes & fees

9.4/10 Exceptional! (979 reviews)

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia

Book Hotels in Southeast Missouri on Expedia.com

Southeast Missouri Hotels from ₹6,018

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Madison Inn Lodge

3. Hampton Inn & Suites By Hilton Festus

4. Holiday Inn Express & Suites Perryville by IHG

5. Super 8 by Wyndham Farmington

6. Fort Davidson Hotel

7. Fairfield Inn & Suites by Marriott Poplar Bluff

8. EC Reed's Mercantile and Hotel

9. Baymont Inn and Suites by Wyndham Farmington, MO

10. Drury Inn & Suites Poplar Bluff

11. Crown Pointe Lodge, BW Signature Collection

12. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

13. Super 8 by Wyndham Perryville

14. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

15. Fairfield Inn & Suites by Marriott Cape Girardeau

16. Hampton Inn Farmington

17. Microtel Inn & Suites by Wyndham Sainte Genevieve

18. Holiday Inn Poplar Bluff by IHG

19. The Riverview

20. Drury Inn & Suites Jackson MO

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

The Atrium - A Boutique Hotel

Tiny Houses of French Village

Urban Lofts

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Hot Tub & Creek Views: Secluded Perryville Cabin

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Super 8 by Wyndham Sikeston/Miner Area

The Riverview

Hampton Inn Poplar Bluff

Pear Tree Inn Cape Girardeau West

Motel 6 Poplar Bluff, MO

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia

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