𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southeast Missouri (2026)

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Southeast Missouri

Pet friendly

Apartment

Hot tub

Condo

Pool

Cottage

Family friendly

Waterpark

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Southeast Missouri hotels

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

1. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Dionysia

₹6,878

₹7,760 total

includes taxes & fees

6 Sept - 7 Sept

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

A hotel room with two beds, a nightstand, a lamp, and a chair.

An outdoor patio with tables and chairs, a stone wall, and large windows.

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Shawn

₹8,840

₹9,567 total

includes taxes & fees

30 Aug - 31 Aug

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A reception area with a sign for 'Travel Inn and Suites'.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A Travel Inn and Suites building with a prominent illuminated sign, a brick facade, and a parking lot.

3. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

₹5,889

₹6,713 total

includes taxes & fees

30 Aug - 31 Aug

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

4. Drury Inn & Suites Sikeston, MO

Sikeston

Sally

₹8,980

₹10,325 total

includes taxes & fees

14 Sept - 15 Sept

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

5. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Matthew

₹9,554

₹10,778 total

includes taxes & fees

2 Sept - 3 Sept

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A reception area with a wooden counter, a desk, and a computer.

A breakfast area with a coffee machine, two coffee dispensers labeled 'Farm Brothers', and cereal boxes including 'Raisin Bran' and 'Frosted Flakes'.

A laundry area with two washing machines and a dryer.

6. Super 8 by Wyndham Potosi

Potosi

Ross

₹5,555

₹6,067 total

includes taxes & fees

3 Sept - 4 Sept

A motel with a covered entrance, a flag, and a phone number.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

7. Madison Inn Lodge

Fredericktown

Melissa

₹8,350

₹9,120 total

includes taxes & fees

8 Sept - 9 Sept

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A multi-story hotel with a mix of brick and red facade, featuring a Holiday Inn Express sign.

8. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

₹9,459

₹10,671 total

includes taxes & fees

27 Sept - 28 Sept

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A gym with cardio equipment, a bench press, and a squat rack.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

9. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

ILUNGA

₹5,580

₹6,074 total

includes taxes & fees

13 Sept - 14 Sept

10. Deerfield Inn & Suites Steele Near Blytheville I 55

Steele

CHARLES

₹4,690

₹5,615 total

includes taxes & fees

29 Aug - 30 Aug

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

11. Fort Davidson Hotel

Ironton

richard

₹11,927

₹13,028 total

includes taxes & fees

7 Sept - 8 Sept

A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

A hotel room with two beds, a desk, a chair, a TV mounted on the wall, and a mirror.

A hotel reception area with a modern design, featuring a reception desk, a glass door, and a wall with framed pictures and a large number '6' sign.

A motel with a prominent '66' sign, large windows, and a flat roof.

12. Motel 6 Poplar Bluff, MO

Poplar Bluff

Kathleen

₹7,538

₹8,441 total

includes taxes & fees

10 Sept - 11 Sept

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

A corner market with a refrigerated display case and a pantry area.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

13. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Arsenia

₹9,664

₹10,918 total

includes taxes & fees

7 Sept - 8 Sept

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

14. Drury Inn & Suites Jackson MO

Jackson

Jamie

₹8,120

₹8,585 total

includes taxes & fees

22 Sept - 23 Sept

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A building with a red awning labeled "Shepherd Mountain Inn."

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

15. Shepherd Mountain Inn

Ironton

Katie

₹11,781

₹12,868 total

includes taxes & fees

31 Aug - 1 Sept

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

16. Super 8 by Wyndham Farmington

Farmington

Saundra

₹5,847

₹6,365 total

includes taxes & fees

6 Sept - 7 Sept

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

17. Super 8 By Wyndham Marston

Marston

Rachel

₹8,845

₹10,103 total

includes taxes & fees

24 Sept - 25 Sept

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

18. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

₹9,459

₹10,710 total

includes taxes & fees

27 Sept - 28 Sept

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

19. Hampton Inn Sikeston

Sikeston

Jeffrey

₹9,715

₹11,000 total

includes taxes & fees

20 Sept - 21 Sept

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

20. Hampton Inn Poplar Bluff

Poplar Bluff

Philip

₹8,932

₹10,001 total

includes taxes & fees

13 Sept - 14 Sept

View all properties

Holiday Rentals in Southeast Missouri

Cabin

A view through a window with a stone wall and a wooden structure in the background.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Cabin

A wooden deck with a railing leading to a building with a metal roof and a brown door.

A bedroom with a wooden bed, a bench, and a window.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A cozy living room with wooden ceilings, a ceiling fan, two sofas, a coffee table, a rug, and a bookshelf with books and games.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

A dining area with a glass table and chairs, wooden flooring, and large windows.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

See properties

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

See properties

A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

See properties

Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

See properties

Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

See properties

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Honeysuckle Inn - Mountain View

10/10 Excellent

"We only stayed for one night. We basically just slept there and it was very clean and nice for what we needed it for. But if you were to shower there you definitely need your own hygiene products because they just had one set of the tiny bottles so not enough for 2 people. Other then that it was pretty decent as far as road side hotels go."

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Good location and reasonable prices"

Baymont by Wyndham Festus

8/10 Good

"Breakfast was good for the cost of room. Very friendly"

Drury Inn & Suites Sikeston, MO

8/10 Good

"Dana wasn’t very happy while check in"

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Wonderful stay. Clean, quiet, friendly staff. Will choose Candlewood again."

Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent

"loved it!!!"

Comfort Inn Festus - St Louis South

8/10 Good

"Staff was very friendly and helpful. Room could have been a little cleaner. Standard free breakfast. Room needed some repairs."

Holiday Inn Poplar Bluff by IHG

8/10 Good

"The room was clean but other parts like the elevator were very dirty. Staff were amazing"

The Riverview

8/10 Good

"Nice view of the river. The staff was nice."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

₹5,580

₹6,074 total

13 Sept - 14 Sept

includes taxes & fees

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

₹5,782

₹6,757 total

20 Sept - 21 Sept

includes taxes & fees

7.8/10 Good! (993 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

₹6,253

₹7,127 total

31 Aug - 1 Sept

includes taxes & fees

7.2/10 Good! (1,000 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

₹7,538

₹8,441 total

10 Sept - 11 Sept

includes taxes & fees

8/10 Very good! (1,000 reviews)

The Farmstead Hotel

778 E 3rd St Caruthersville MO

₹9,029

₹10,268 total

11 Sept - 12 Sept

includes taxes & fees

8.6/10 Excellent! (602 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

₹9,459

₹10,671 total

27 Sept - 28 Sept

includes taxes & fees

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia

Book Hotels in Southeast Missouri on Expedia.com

Southeast Missouri Hotels from ₹6,074

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Pear Tree Inn Cape Girardeau West

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

4. Drury Inn & Suites Sikeston, MO

5. Drury Plaza Hotel Cape Girardeau Conference Center

6. Super 8 by Wyndham Potosi

7. Madison Inn Lodge

8. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

9. Baymont Inn and Suites by Wyndham Farmington, MO

10. Deerfield Inn & Suites Steele Near Blytheville I 55

11. Fort Davidson Hotel

12. Motel 6 Poplar Bluff, MO

13. Fairfield Inn & Suites by Marriott Poplar Bluff

14. Drury Inn & Suites Jackson MO

15. Shepherd Mountain Inn

16. Super 8 by Wyndham Farmington

17. Super 8 By Wyndham Marston

18. Holiday Inn Express & Suites Sikeston Southwest by IHG

19. Hampton Inn Sikeston

20. Hampton Inn Poplar Bluff

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Lake Wappapello

The Atrium - A Boutique Hotel

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Tiny Houses of French Village

Urban Lofts

Cozy Belgrade Cottage w/ Wood-burning Stove!

Walk to Current River: Ozarks Adventure Home!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Honeysuckle Inn - Mountain View

Pear Tree Inn Cape Girardeau West

Baymont by Wyndham Festus

Drury Inn & Suites Sikeston, MO

Candlewood Suites Cape Girardeau by IHG

Fairfield Inn & Suites by Marriott Poplar Bluff

Comfort Inn Festus - St Louis South

Holiday Inn Poplar Bluff by IHG

The Riverview

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Comfort Inn Festus - St Louis South

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

The Farmstead Hotel

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia

Go further with the Expedia app