Downtown South San Francisco Travel Guide

San Francisco

Aerial View of a Local High School and an Athletic Field in a Neighborhood in South San Francisco, California, USA
Aerial view of the South San Francisco area
Aerial view of downtown San Francisco and Financial District sky scrapers flying over South San Francisco The Industrial City inscription on San Bruno mountain circa 2015

Popular places to visit


Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ₹11,020 per night from 8 May to 9 May
₹11,020
₹12,906 total
8 May - 9 May
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
8.2/10 Very Good! (1,964 reviews)
👌

Reviewed on 4 May 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ₹11,990 per night from 11 May to 12 May
₹11,990
₹18,029 total
11 May - 12 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,439 reviews)
Great stay!

Reviewed on 4 May 2026

Hotel Riu Plaza Fisherman's Wharf
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ₹12,528 per night from 10 May to 11 May
₹12,528
₹14,745 total
10 May - 11 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
9/10 Wonderful! (5,682 reviews)
This was a great stay ! Near everything ! Very convenient. The parking lot to elevator was sketchy . I felt like I was gunna get assaulted but that had nothing to do with the hotel . I would most definitely stay here again .. if parking came with hotel stay . But it doesn’t . You pay about $50 for ...

Reviewed on 4 May 2026

Holiday Inn Golden Gateway by IHG
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
The price is ₹13,035 per night from 25 May to 26 May
₹13,035
₹15,340 total
25 May - 26 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the ...
9/10 Wonderful! (3,102 reviews)
Hotel was perfectly clean, the photos of it are a little misleading. It’s not that nice!

Reviewed on 4 May 2026

Club Quarters Hotel in San Francisco
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
The price is ₹18,922 per night from 8 May to 9 May
₹18,922
₹26,641 total
8 May - 9 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (2,212 reviews)
One of the best breakfast , great amenities, must experience.

Reviewed on 4 May 2026

Hyatt Regency San Francisco
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is ₹15,138 per night from 25 May to 26 May
₹15,138
₹17,817 total
25 May - 26 May
includes taxes & fees
Stay at this family-friendly hotel in San Francisco. Enjoy free Wi-Fi, a fitness centre and valet parking (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,092 reviews)
The best thing about this hotel was its excellent location. It was steps away from Union Square and walking distance to many stores, restaurants, the cable cars and other SF attractions. The hotel of course is quite dated, being a historic building, and does not have a restaurant on site.

Reviewed on 4 May 2026

Handlery Union Square Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Downtown South San Francisco

Aerial View Of Urban Neighborhood

Noe Valley

Appreciated for its churches and architecture, you might consider exploring Noe Valley. Check out the variety of things to see and do like 22nd St Hill, and jump on the metro at Church St & Clipper St Stop or Church St & 24th St Stop to get around the city.

Noe Valley
Mission District

Mission District

3.5/5(11 area reviews)

You might enjoy the bars while in Mission District. San Francisco Public Library is a notable sight, and you can get around town at 16th Street Mission Station or 24th Street Mission Station to see more of the city.

Mission District
Sunset District

Sunset District

3.5/5(6 area reviews)

Consider exploring the beaches in Sunset District. If sightseeing is on the list, Ocean Beach is a top attraction. Hop on the metro at Judah Street & Sunset Boulevard Station or Judah St & 34th Ave Stop to see more of the area.

Sunset District
Aerial Mission Bay with Mission Rock and view of tankers in San Francisco Bay

Mission Bay

While you're in Mission Bay, take in top sights like Chase Center or Lefty O'Doul Bridge, and hop on the metro to see more of the city at UCSF/Chase Center Stop or Mission Rock Station.

Mission Bay
South of Market

South of Market

3.5/5(115 area reviews)

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

South of Market
Golden Gate

Golden Gate

If you're spending time in Golden Gate, check out sights like San Francisco Botanical Garden or Japanese Tea Garden and hop on the metro to see more of the city at Irving St & 9th Ave Stop or Irving St & 8th Ave Stop.

Golden Gate


Downtown South San Francisco Travel Guide