Search Hotels in Downtown South San Francisco, San Francisco

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14 Nov - 15 Nov
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Our top choices for Downtown South San Francisco hotels

A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.2 out of 10, Very good, (2,137 reviews)
"Satisfying stay!"
United States
Andree
The price is ₹10,312
₹12,091 total
includes taxes & fees
24 Nov - 25 Nov
La Quinta Inn & Suites by Wyndham San Francisco Airport N
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.

2. Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
9.0 out of 10, Wonderful, (1,000 reviews)
"One of the best places I’ve stayed in SF area"
United States
Saikiran
The price is ₹10,834
₹12,667 total
includes taxes & fees
23 Nov - 24 Nov
Airport Inn
A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.

3. Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.2 out of 10, Good, (26 reviews)
"Nice place to stay"
United States
Tora
The price is ₹4,156
₹12,035 total
includes taxes & fees
26 Nov - 27 Nov
Miller Apartments
A hotel room with a bed, a desk, a chair, a TV, and a lamp.

4. Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.6 out of 10, Good, (1,001 reviews)
"Awesome place staff was very helpful and friendly room was clean and well organized 10 out of 10"
United States
desmon
Inn By The SFO
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
3.5 star property
The East Side, 1.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,853 reviews)
"Great breakfast people were very friendly."
Canada
Florence
The price is ₹13,780
₹16,178 total
includes taxes & fees
4 Dec - 5 Dec
Embassy Suites by Hilton San Francisco Airport Oyster Point
A courtyard with outdoor seating, a glass table, and potted plants.

6. Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
2.5 star property
The East Side, 1.1 km from Downtown South San Francisco
7.8 out of 10, Good, (1,001 reviews)
"The only negative thing I have to say is that we had to pay parking per night we stayed 😔 Everything else was perfect! Staff was super friendly and place was awesome to stay."
United States
Mary
The price is ₹9,726
₹11,416 total
includes taxes & fees
5 Dec - 6 Dec
Comfort Inn and Suites San Francisco Airport North
An outdoor patio with modern seating, a fire feature, and string lights.

7. Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
3.0 star property
The East Side, 1.5 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1,292 reviews)
"Very nice hotel"
United States
John
The price is ₹11,515
₹13,472 total
includes taxes & fees
29 Nov - 30 Nov
Home2 Suites by Hilton San Francisco Airport North
A restaurant setting with round tables, chairs, and empty wine glasses.

8. Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
3.0 star property
1.8 km from Downtown South San Francisco
8.4 out of 10, Very good, (1,907 reviews)
"We enjoyed the hospitality of staff and the breakfast was great & always stocked !"
United States
Mechelle
The price is ₹10,144
₹11,952 total
includes taxes & fees
29 Nov - 30 Nov
Best Western Plus Grosvenor Airport Hotel
A hotel lobby with a reception desk, a coffee station, and seating areas.

9. Hotel Nova SFO

Hotel Nova SFO
2.5 star property
1.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,004 reviews)
"Nice breakfast, clean rooms"
United States
Noel
The price is ₹9,216
₹10,811 total
includes taxes & fees
4 Dec - 5 Dec
Hotel Nova SFO
A hotel lobby with a central reception desk, large columns, and hanging pendant lights.

10. Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
3.0 star property
The East Side, 1.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,003 reviews)
"The staff was very helpful and friendly"
Canada
Emily
The price is ₹8,406
₹9,897 total
includes taxes & fees
23 Nov - 24 Nov
Hilton Garden Inn San Francisco Arpt North
Exterior

11. Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
3.0 star property
Oyster Point, 2.2 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2,402 reviews)
"Hotel staff was very friendly and the rooms were clean."
United States
Alyssa
The price is ₹9,404
₹11,045 total
includes taxes & fees
23 Nov - 24 Nov
Sonesta Select San Francisco Airport Oyster Point Waterfront
A hotel room with a bed, a sofa, a nightstand, and a desk. There are three framed pictures on the wall.

12. The Atrium Hotel at SFO

The Atrium Hotel at SFO
2.5 star property
3 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,037 reviews)
"It was a very nice property, would stay again!"
United States
Jeremy
The price is ₹8,921
₹10,896 total
includes taxes & fees
29 Nov - 30 Nov
The Atrium Hotel at SFO
A reception area with a wooden reception desk, a television, and a flower vase.

13. Hotel Focus SFO

Hotel Focus SFO
3.0 star property
The East Side, 1.3 km from Downtown South San Francisco
7.6 out of 10, Good, (1,684 reviews)
"Everything was super easy from check in to breakfast to airport bus."
United States
Laurel
The price is ₹7,390
₹8,730 total
includes taxes & fees
6 Dec - 7 Dec
Hotel Focus SFO
A modern interior with a wooden partition, a stone accent wall, and a bar area.

14. DoubleTree by Hilton San Francisco Airport North Bayfront

DoubleTree by Hilton San Francisco Airport North Bayfront
4.0 star property
3.1 km from Downtown South San Francisco
8.2 out of 10, Very good, (1,814 reviews)
"Convenient location"
United States
Alejandro
The price is ₹8,406
₹9,941 total
includes taxes & fees
23 Nov - 24 Nov
DoubleTree by Hilton San Francisco Airport North Bayfront
A modern lobby with a cityscape mural, a reception desk, seating area, and a door with blinds.

15. Hotel Skye SFO

Hotel Skye SFO
3.0 star property
3.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,123 reviews)
"We enjoyed our stay"
United States
Yelizaveta
The price is ₹9,512
₹11,455 total
includes taxes & fees
24 Nov - 25 Nov
Hotel Skye SFO
A spacious, well-lit atrium with a high ceiling and skylight, featuring a central seating area with a sofa and armchairs, surrounded by a patterned rug.

16. Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
3.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2,997 reviews)
"Great stay for great price"
United States
Adrian
The price is ₹9,065
₹10,940 total
includes taxes & fees
24 Nov - 25 Nov
Hotel Aluxor SFO
A reception area with a counter, two patterned chairs, a yellow ottoman, and a large blue potted plant.

17. Hotel Aura SFO

Hotel Aura SFO
3.0 star property
4.4 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,637 reviews)
"Comfortable rooms, nice breakfast, helpful staff."
United States
Pam
The price is ₹8,990
₹10,787 total
includes taxes & fees
3 Dec - 4 Dec
Hotel Aura SFO
An outdoor patio with wooden furniture, a chessboard, and hanging floral decorations.

18. The Millwood - A Boutique Hotel

The Millwood - A Boutique Hotel
3.0 star property
5.4 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (1,047 reviews)
"best stay"
United States
Chitla
The price is ₹12,163
₹14,523 total
includes taxes & fees
11 Dec - 12 Dec
The Millwood - A Boutique Hotel
A modern storefront with a neon sign reading "The Dylan."

19. The Dylan at SFO

The Dylan at SFO
3.0 star property
7.1 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (1,906 reviews)
"It was a good place to stay near airport"
United States
Ellen
The price is ₹12,221
₹14,471 total
includes taxes & fees
22 Nov - 23 Nov
The Dylan at SFO
A hotel room with a bed, bedside tables, a desk, a chair, and a large window.

20. Gateway Inn & Suites San Francisco SFO Airport

Gateway Inn & Suites San Francisco SFO Airport
2.0 star property
3.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,201 reviews)
"Great location to SFO Airport with ample parking. Room was very clean and pleasantly quiet. Stayed one night and had great accomadations."
United States
Angie
The price is ₹8,248
₹9,936 total
includes taxes & fees
22 Nov - 23 Nov
Gateway Inn & Suites San Francisco SFO Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in Downtown South San Francisco

A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3.0 star property
Downtown South San Francisco
View
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.

Airport Inn

2.0 star property
Downtown South San Francisco
View
A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.

Miller Apartments

2.0 star property
Downtown South San Francisco
View
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 star property
The East Side, 1.4 km from Downtown South San Francisco
View
A courtyard with outdoor seating, a glass table, and potted plants.

Comfort Inn and Suites San Francisco Airport North

2.5 star property
The East Side, 1.1 km from Downtown South San Francisco
View
8.2
Very good
2,137 reviews
9.0
Wonderful
1,000 reviews
7.2
Good
26 reviews
8.8
Excellent
1,853 reviews
7.8
Good
1,001 reviews
The price is ₹10,312
₹12,091 total
includes taxes & fees
24 Nov - 25 Nov
The price is ₹10,834
₹12,667 total
includes taxes & fees
23 Nov - 24 Nov
The price is ₹4,156
₹12,035 total
includes taxes & fees
26 Nov - 27 Nov
The price is ₹13,780
₹16,178 total
includes taxes & fees
4 Dec - 5 Dec
The price is ₹9,726
₹11,416 total
includes taxes & fees
5 Dec - 6 Dec
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • No Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • No Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • No Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • No WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • No Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking

Hotels recommended for families in Downtown South San Francisco

A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.2 out of 10, Very good, (2,137)
The price is ₹10,312
₹12,091 total
includes taxes & fees
24 Nov - 25 Nov
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

One of the biggest and most popular shopping plazas across the United States.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

A historic neighbourhood by the waterfront, and a great place to eat out and enjoy the busy surroundings.

A city street with tall buildings, flags, and cars.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

Top Downtown South San Francisco Hotel Reviews

An outdoor patio with modern seating, a fire feature, and string lights.
Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side

10/10 Excellent

We were 5 of us staying for 1night. No problems. Everything was ok
United Kingdom
Marta
Reviewed July 5, 2026
Home2 Suites by Hilton San Francisco Airport North

Frequently Asked Questions

What's it like in Downtown South San Francisco?

You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.

What's a favourite place to stay in Downtown South San Francisco?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.

How many hotels should I expect to find in the Downtown South San Francisco area?

When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 11 Expedia hotels and other accommodation options in Downtown South San Francisco.

If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.

What can I see and do in this South San Francisco neighbourhood?

South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.