What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa .

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

The Best Hotels in Otay Mesa, San Diego - 2026 Updated Prices

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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Otay Mesa

Mary

₹10,168 total

includes taxes & fees

17 Jan - 18 Jan

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Otay Mesa

Zulma

₹12,223 total

includes taxes & fees

25 Jan - 26 Jan

Berkshire Motor Hotel

North Park, 26.7 km from Otay Mesa

Susana

₹8,329 total

includes taxes & fees

25 Jan - 26 Jan

Westgate Hotel

24.9 km from Otay Mesa

Victor

Sea Harbor Hotel

30.1 km from Otay Mesa

Dennis

Courtyard by Marriott Old Town

Old Town San Diego, 29.7 km from Otay Mesa

Kathleen

₹14,032 total

includes taxes & fees

22 Jan - 23 Jan

Springhill Suites San Diego Mission Valley

28.2 km from Otay Mesa

Jodi

₹16,502 total

includes taxes & fees

19 Jan - 20 Jan

Premium Room, 1 King Bed, Non Smoking, Ocean View (Non-Pet friendly) | Iron/ironing board, free WiFi, bed sheets

Ocean Villa Inn

Ocean Beach, 33.7 km from Otay Mesa

Marcin

Heritage Inn San Diego

31.8 km from Otay Mesa

Carey

₹5,686 total

includes taxes & fees

18 Jan - 19 Jan

Best Western Plus Bayside Inn

25.4 km from Otay Mesa

Nara

₹13,627 total

includes taxes & fees

25 Jan - 26 Jan

La Pensione Hotel

Little Italy, 25.8 km from Otay Mesa

Jingying

Deluxe 2 Queen with sofa sleeper | Bathroom | Combined shower/bathtub, free toiletries, hair dryer, towels

Old Town Western Inn & Suites

Old Town San Diego, 29.6 km from Otay Mesa

Raul

Premium bedding, pillow-top beds, desk, laptop workspace

Staypineapple, Hotel Z, Gaslamp San Diego

Gaslamp Quarter, 24.2 km from Otay Mesa

Lee

₹11,508 total

includes taxes & fees

25 Jan - 26 Jan

Hampton Inn & Suites by Hilton San Diego SeaWorld

30.8 km from Otay Mesa

Jorge

₹11,381 total

includes taxes & fees

25 Jan - 26 Jan

Ocean Beach Hotel

Ocean Beach, 33.5 km from Otay Mesa

Maryna

Outdoor pool, open 7:00 AM to 10:00 PM, free pool cabanas, pool loungers

Hilton Garden Inn San Diego Downtown/Bayside

26.2 km from Otay Mesa

savannah

₹14,430 total

includes taxes & fees

19 Jan - 20 Jan

The Beau Downtown San Diego Gaslamp Quar

Gaslamp Quarter, 24.5 km from Otay Mesa

Janet

₹12,361 total

includes taxes & fees

29 Jan - 30 Jan

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Old Town San Diego, 30.5 km from Otay Mesa

Juan

₹13,609 total

includes taxes & fees

25 Jan - 26 Jan

Hampton Inn & Suites San Diego Airport Liberty Station

29.2 km from Otay Mesa

Alison

₹17,556 total

includes taxes & fees

24 Jan - 25 Jan

Standard Room, 2 Queen Beds, Non Smoking, Microwave | Desk, blackout curtains, iron/ironing board, cots/infant beds

Best Western Yacht Harbor Hotel

29.9 km from Otay Mesa

DAVID

₹11,605 total

includes taxes & fees

19 Jan - 20 Jan

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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

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Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

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Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

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Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

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