A city skyline with high-rise buildings and a bridge over a body of water.

Search Hotels in Otay Mesa, San Diego

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
17 Jul - 19 Jul
Next weekend
24 Jul - 26 Jul

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Otay Mesa hotels

Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,778 reviews)
"Was happy with my stay! No complaints 👌"
United States
Rafael
The price is ₹14,623
₹16,633 total
includes taxes & fees
13 Aug - 14 Aug
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Free on-the-go breakfast

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,025 reviews)
"Very clean, bed was comfortable!"
United States
Michael A
The price is ₹11,456
₹13,031 total
includes taxes & fees
2 Aug - 3 Aug
Quality Suites San Diego Otay Mesa
Free continental breakfast

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (1,874 reviews)
"Nice right by the concert we were going to and staff was nice."
United States
vanessa
The price is ₹12,184
₹13,426 total
includes taxes & fees
2 Aug - 3 Aug
Best Western Chula Vista/Otay Valley Hotel
Premium bedding, desk, blackout curtains, soundproofing

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,049 reviews)
"It was a good stay."
United States
AILEEN
The price is ₹7,792
₹8,879 total
includes taxes & fees
28 Jul - 29 Jul
Valli Hi Motel
Exterior

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,719 reviews)
"A good place to stay if you need a place to crash in for the night"
United States
Ivy Ruth
The price is ₹7,407
₹8,544 total
includes taxes & fees
16 Aug - 17 Aug
Motel 6 El Cajon, CA - San Diego
Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,911 reviews)
"Nice location and clean hotel."
United States
Abdelghani
The price is ₹17,232
₹18,989 total
includes taxes & fees
19 Jul - 20 Jul
Best Western Plus Marina Gateway Hotel
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,090 reviews)
"We really enjoyed the cleanliness and the manager Karen was excellent 😊"
United States
Deniece
The price is ₹19,928
₹21,959 total
includes taxes & fees
2 Aug - 3 Aug
Ayres Hotel San Diego South - Chula Vista
Lobby

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,602 reviews)
"The room was comfortable and conveniently located. Breakfast was great for the cost of our stay."
United States
Arsenia P
The price is ₹12,143
₹13,382 total
includes taxes & fees
16 Aug - 17 Aug
Comfort Inn Chula Vista San Diego South
Lobby

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,707 reviews)
"As usual everything about our stay was great."
United States
Edward
The price is ₹15,962
₹18,348 total
includes taxes & fees
3 Aug - 4 Aug
Hampton Inn & Suites San Diego Airport Liberty Station
Standard Single Room, 1 King Bed, Non Smoking | Desk, blackout curtains, iron/ironing board (on request), free WiFi

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.2 out of 10, Good, (2,278 reviews)
"Excelente hotel"
Mexico
ERICK GUADALUPE
The price is ₹7,318
₹8,050 total
includes taxes & fees
29 Jul - 30 Jul
Hotel Palmeras Chula Vista
Outdoor pool, open 9:00 AM to 5:00 PM, pool cabanas (surcharge)

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,013 reviews)
"Exceptional hotel, staff and amenities. Love this hotel!"
United States
CAROL
The price is ₹11,939
₹14,287 total
includes taxes & fees
5 Aug - 6 Aug
Sycuan Casino Resort
Exterior

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,084 reviews)
"Very good hotel at the price with good choice of breakfast."
United States
Tirthankar
The price is ₹16,172
₹18,589 total
includes taxes & fees
16 Aug - 17 Aug
Holiday Inn Express San Diego Airport - Old Town by IHG
Lobby

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,344 reviews)
"Clean room, ac was perfect staff was great"
United States
Brandon
The price is ₹12,036
₹13,691 total
includes taxes & fees
9 Aug - 10 Aug
Best Western Americana Inn
Arcade

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,166 reviews)
"Fun vibe, would definitely stay here again!"
United States
Jennifer
The price is ₹12,900
₹14,925 total
includes taxes & fees
16 Aug - 17 Aug
The Rambler Hotel
Studio Suite, 1 King Bed with Sofa bed, Balcony | View from room

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,577 reviews)
"Great stay"
United States
Karen
The price is ₹19,157
₹26,890 total
includes taxes & fees
12 Aug - 13 Aug
Sheraton San Diego Resort
Property amenity

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,663 reviews)
"Very nice and clean hotel"
United States
Lidia
The price is ₹12,043
₹13,248 total
includes taxes & fees
9 Aug - 10 Aug
La Quinta Inn by Wyndham San Diego Chula Vista
Lobby

TownePlace Suites by Marriott San Diego Airport/Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station
3.0 star property
29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,000 reviews)
"So convenient, great staff, excellent shuttle service, clean hotel I was very impressed."
United States
Terry
The price is ₹18,713
₹21,509 total
includes taxes & fees
16 Aug - 17 Aug
TownePlace Suites by Marriott San Diego Airport/Liberty Station
Exterior

WoodSpring Suites Santee - San Diego Northeast

WoodSpring Suites Santee - San Diego Northeast
2.5 star property
30.9 km from Otay Mesa
8.4 out of 10, Very good, (160 reviews)
"Ashley, at the front desk was so happy and helpful!! Made my quick check in and shirt stay very easy!"
United States
Cortney
The price is ₹11,456
₹12,602 total
includes taxes & fees
19 Jul - 20 Jul
WoodSpring Suites Santee - San Diego Northeast
Outdoor wedding area

Carlton Oaks Lodge, an Ascend Collection Hotel

Carlton Oaks Lodge, an Ascend Collection Hotel
3.0 star property
31.6 km from Otay Mesa
8.2 out of 10, Very good, (1,005 reviews)
"Loved the restaurant!!"
United States
Krista
The price is ₹9,938
₹14,109 total
includes taxes & fees
19 Jul - 20 Jul
Carlton Oaks Lodge, an Ascend Collection Hotel
Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, free WiFi, bed sheets

Hotel Milagro

Hotel Milagro
2.0 star property
14.9 km from Otay Mesa
7.6 out of 10, Good, (1,001 reviews)
"Great hotel"
United States
Mary
The price is ₹7,909
₹8,699 total
includes taxes & fees
27 Jul - 28 Jul
Hotel Milagro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Seaport Village are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A beach with surfers and swimmers during sunset.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Loews Coronado Bay Resort

Loews Coronado Bay Resort

8/10 Good
"Easy shuttle to town, pool relaxing and great room service."
Shawna 5-night trip
Posted 5 hours ago
Loews Coronado Bay Resort

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Explore a world of travel with Expedia