Search Hotels in Otay Mesa, San Diego

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
2 Sept - 3 Sept
Tomorrow
3 Sept - 4 Sept
This weekend
5 Sept - 7 Sept
Next weekend
12 Sept - 14 Sept

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Otay Mesa, San Diego

Our top choices for Otay Mesa hotels

Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1082)
"Beautiful property!! "
The price is ₹11,618
₹12,802 total
includes taxes & fees
15 Sept - 16 Sept
Ayres Hotel San Diego South - Chula Vista
Sycuan Casino Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1522)
"Love this place"
Sycuan Casino Resort
Best Western Americana Inn
Pillow-top beds, in-room safe, desk, laptop workspace

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1146)
"Breakfast was amazing! "
The price is ₹9,236
₹10,506 total
includes taxes & fees
3 Sept - 4 Sept
Best Western Americana Inn
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
8.0 out of 10, Very good, (1450)
"Very good to stayed "
The price is ₹10,760
₹12,240 total
includes taxes & fees
8 Sept - 9 Sept
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Quality Suites San Diego Otay Mesa
Desk, laptop workspace, blackout curtains, iron/ironing board

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1013)
"Nice place. Clean and quiet. "
The price is ₹9,565
₹10,881 total
includes taxes & fees
21 Sept - 22 Sept
Quality Suites San Diego Otay Mesa
SpringHill Suites by Marriott Chula Vista Eastlake
Outdoor pool

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (427)
"Customer service was wonderful for our short stay"
The price is ₹12,083
₹13,315 total
includes taxes & fees
7 Sept - 8 Sept
SpringHill Suites by Marriott Chula Vista Eastlake
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1401)
"Great place to stay at , along with a good breakfast variety. Overall I'll stay here again"
The price is ₹8,811
₹9,692 total
includes taxes & fees
7 Sept - 8 Sept
La Quinta Inn by Wyndham San Diego Chula Vista
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3279)
"Good place to stay"
The price is ₹11,035
₹12,160 total
includes taxes & fees
14 Sept - 15 Sept
Best Western Plus Marina Gateway Hotel
Lamplighter Inn & Suites at SDSU
Outdoor pool, pool umbrellas, pool loungers

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1253)
"We will definitely be staying there again"
Lamplighter Inn & Suites at SDSU
Lafayette Hotel & Club
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)

Lafayette Hotel & Club

4.0 star property
9.2 out of 10, Wonderful, (1119)
"I absolutely love this place! Great food and great people all around"
The price is ₹19,933
₹22,873 total
includes taxes & fees
22 Sept - 23 Sept
Lafayette Hotel & Club
Hampton Inn & Suites San Diego Seaworld
Reception

Hampton Inn & Suites San Diego Seaworld

2.5 star property
8.4 out of 10, Very good, (28)
"Enjoyed our stay."
The price is ₹10,421
₹11,978 total
includes taxes & fees
9 Sept - 10 Sept
Hampton Inn & Suites San Diego Seaworld
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very good, (1000)
"Great location!"
The price is ₹8,749
₹9,624 total
includes taxes & fees
21 Sept - 22 Sept
Best Western Plus La Mesa San Diego
Legacy Resort Hotel & Spa
Garden

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2884)
"Legacy resorts was a very nice place to stay. "
The price is ₹12,881
₹14,805 total
includes taxes & fees
21 Sept - 22 Sept
Legacy Resort Hotel & Spa
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1481)
"Great hotel"
The price is ₹9,671
₹10,638 total
includes taxes & fees
14 Sept - 15 Sept
Best Western Chula Vista/Otay Valley Hotel
Berkshire Motor Hotel
Suite | Private kitchenette

Berkshire Motor Hotel

2.5 star property
8.4 out of 10, Very good, (969)
"Great location within walking distance from the places we wanted to visit."
The price is ₹8,327
₹9,389 total
includes taxes & fees
7 Sept - 8 Sept
Berkshire Motor Hotel
Best Western San Diego Pacific Beach/Mission Bay
Outdoor pool

Best Western San Diego Pacific Beach/Mission Bay

2.5 star property
7.2 out of 10, Good, (1285)
"Friendly staff!"
The price is ₹7,541
₹8,668 total
includes taxes & fees
3 Sept - 4 Sept
Best Western San Diego Pacific Beach/Mission Bay
Sea Harbor Hotel
Marina

Sea Harbor Hotel

2.0 star property
8.4 out of 10, Very good, (954)
"Good property for a few nights before your get on your boat for a fishing trip! "
The price is ₹12,485
₹14,077 total
includes taxes & fees
4 Sept - 5 Sept
Sea Harbor Hotel
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1031)
"Nice rooms, great staff close to beach"
The price is ₹20,198
₹26,468 total
includes taxes & fees
7 Sept - 8 Sept
Loews Coronado Bay Resort
Best Western Plus Suites Hotel Coronado Island
Outdoor pool, pool loungers

Best Western Plus Suites Hotel Coronado Island

2.5 star property
8.8 out of 10, Excellent, (1012)
"Location was convenient, rooms were spacious. Staff was kind. "
The price is ₹17,495
₹19,245 total
includes taxes & fees
21 Sept - 22 Sept
Best Western Plus Suites Hotel Coronado Island
Valli Hi Motel
Desk, blackout curtains, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very good, (1017)
"Great hotel "
Valli Hi Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.