Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Top hotels in Otay Mesa
Hilton San Diego Mission Valley
Didn’t use the pool but area very well maintained Only negative comment Saturday morning went to the front desk to have only our beds made . Came back to the hotel at 7:00 pm beds were not made very disappointing I did call when I came back to my room the front desk so the supervisor of my housekeeper ...
Reviewed on 28 Oct 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
Romm are clean and neat as well as hallways.
Reviewed on 28 Oct 2025
Pendry San Diego
The rooms were very nice and the location is perfect for San Diego. It's a very nice hotel.
Reviewed on 22 Oct 2025
Hard Rock Hotel San Diego
Staff was great. My only two complaint is. The main lobby is over powering with some type of air freshener. And also our balcony door did not lock. It is very noisy at night but you are in down town where all the night life is. It’s a nice stay for sure.
Reviewed on 26 Oct 2025
Courtyard by Marriott San Diego Downtown Little Italy
Staff is amazing 3 time staying here for a reason really. Great place
Reviewed on 28 Oct 2025
InterContinental San Diego by IHG
From check in to relaxing in the harbor view room and friendly staff at breakfast made the stay very memorable.
Reviewed on 24 Oct 2025
Other neighbourhoods around Otay Mesa
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
Otay Mesa Travel Guide
- Places of interest
- Choose Your Otay Mesa Hotel Style
- Hotels in top San Diego neighborhoods
- Search Otay Mesa Hotel Brands
- San Diego Zoo
- Mission Bay
- San Ysidro Border Crossing
- Petco Park
- Balboa Park
- San Diego State University
- Hotel Circle
- USS Midway Museum
- Marine Corps Recruit Depot
- Hotel del Coronado
- Coronado Beach
- Seaport Village
- Old Town San Diego State Park
- Waterfront Park
- Fashion Valley Mall
- North Island Credit Union Amphitheatre
- Shelter Island
- Belmont Park
