Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Mission Beach
A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Top hotels in Otay Mesa
Bay Club Hotel & Marina
I love the Bayclub Hotel and Marina. The staff is helpful and friendly. The views are amazing. The restaurant is very good and they have happy hour from 2:00-6:00 each day. I absolutely enjoy the server Miriam, who works at breakfast time. She is always so friendly, so polite, and we will go out ...
Reviewed on 3 Feb 2026
Hard Rock Hotel San Diego
Very clean hotel. I was always seeing someone cleaning.
Reviewed on 2 Feb 2026
Paradise Point Resort & Spa
Clean
Reviewed on 4 Feb 2026
The DEXTRO Little Italy, BW Premier Collection
Very clean, comfy and spacious room. The staff was friendly and the location was good, if you’re looking to be close to Little Italy restaurants.
Reviewed on 3 Feb 2026
San Diego Mission Bay Resort
Great room, great amenities, the resort was so nice.
Reviewed on 21 Jan 2026
The Sofia Hotel
Excellent location! The staff was friendly and the hotel is lovely. Our room was nice and spacious, and the bed was very comfortable. I would not hesitate to stay here again in the future.
Reviewed on 29 Jan 2026
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
