Photo by cyclone_trudy
Search Hotels by Motel 6 in James Island
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check prices for these dates
Tonight
Tomorrow
This weekend
Next weekend
Top James Island Motel 6 Hotels
Top James Island Hotel Reviews
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Search James Island Hotel Brands
Areas of James Island
Hotels near popular Charleston Attractions
Choose Your James Island Hotel Style
- Adults Only Resorts & Hotels in James Island
- Beach Resorts & Hotels in James Island
- Historic Hotels in James Island
- Hotels with Breakfast in James Island
- Hotels with Laundry Service in James Island
- Hotels with Parking in James Island
- Hotels with Wifi in James Island
- Pet-Friendly Hotels in James Island
- Romantic Hotels in James Island
- Spa Hotels in James Island
More accommodation types in James Island
Explore more hotels
- Hyatt Place Charleston Airport/Convention Center
- Holiday Inn Express & Suites Charleston Dwtn - Westedge by IHG
- The Vendue
- Embassy Suites by Hilton Charleston Historic District
- Tides Folly Beach, Charleston's Oceanfront Hotel
- The Beach Club at Charleston Harbor Resort and Marina
- The Meeting Street Inn
- The Ryder Hotel
- Hyatt Place Charleston/Historic District
- HarbourView Inn
- DoubleTree by Hilton Hotel & Suites Charleston Airport
- The Palmetto Hotel
- The Restoration
- Indigo Inn
- Mills House Charleston, Curio Collection by Hilton
- Andrew Pinckney Inn
- Seaside Inn Oceanfront
- Holiday Inn Charleston Riverview by IHG
- Planters Inn