South Main Travel Guide

Houston

A city skyline with modern buildings and a park with a lake.
A modern urban street with a metro train, buildings, and a clear blue sky.

Top hotels in South Main

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is ₹8,887 per night from 21 Sept to 22 Sept
₹8,887
₹10,398 total
21 Sept - 22 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, a 24-hour fitness centre and a 24-hour front desk. Our guests praise the helpful staff and ...
Wyndham Houston at Reliant Park & Medical Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
The price is ₹11,197 per night from 20 Sept to 21 Sept
₹11,197
₹13,192 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and the clean ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
The price is ₹23,768 per night from 17 Sept to 18 Sept
₹23,768
₹31,584 total
17 Sept - 18 Sept
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...
9.2/10 Wonderful! (1,006 reviews)
"Staff was great! Love the Za Za!"

Reviewed on 13 Sept 2026

Hotel Zaza Houston Museum District
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
The price is ₹8,935 per night from 15 Sept to 16 Sept
₹8,935
₹10,454 total
15 Sept - 16 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful staff ...
Club Quarters Hotel Downtown, Houston
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
The price is ₹13,421 per night from 20 Sept to 21 Sept
₹13,421
₹15,702 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and ...
The Whitehall Houston
Hyatt Regency Houston West

Hyatt Regency Houston West

3.5 out of 5
13210 Katy Fwy Houston TX
Fully refundableReserve now, pay when you stay
The price is ₹9,097 per night from 18 Sept to 19 Sept
₹9,097
₹10,644 total
18 Sept - 19 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the restaurant and the helpful staff ...
8.6/10 Excellent! (1,631 reviews)
"Very nice place to stay! Parking was a little confusing at first but once you figure it out it was great. Suggestion find parking in the covered area and the entry is the double glass doors. Unless you prefer the valet."

Reviewed on 14 Sept 2026

Hyatt Regency Houston West
See all 7,491 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

A person walking in front of a building with a brick facade and three arched windows.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

A large rectangular reflecting pool with a tall building in the background.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

South Main Travel Guide