South Main Travel Guide
Houston
Visit South Main
Top hotels in South Main
Wyndham Houston at Reliant Park & Medical Center
Club Quarters Hotel Downtown, Houston
The Whitehall Houston
"5 stars"
Reviewed on 29 Oct 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Royal Sonesta Houston Galleria
"The room and breakfast was great but I’m early riser need coffee to wake up so I had some issues with the coffee machine broken we called few times to fix only by the last day before checking out they took care of the issue bit upsetting and we called few times the hotel shuttle that it was offered ..."
Reviewed on 29 Oct 2026
Hilton Houston Plaza/Medical Center
"Great hotel. My room was very clean. Bar/restaurant on site with reasonable prices. Front staff is very friendly and very accommodating. They have a breakfast buffet for I think $16-19. Starbucks coffee on site."
Reviewed on 29 Oct 2026
Where to stay in South Main
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
