What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to Reliant Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on our traveller data, Wyndham Houston at Reliant Park & Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from Reliant Park, and it offers a restaurant and an outdoor pool.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

Reliant Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as Reliant Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

The Best Hotels in South Main, Houston - 2026 Updated Prices

A city skyline with modern buildings and a park with a lake.

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Our top choices for South Main hotels

A modern lobby with a blue carpet, seating area, and large windows.

1. Wyndham Houston at Reliant Park & Medical Center

South Main

Miguel

₹10,398 total

includes taxes & fees

21 Sept - 22 Sept

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

2. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

chris

₹10,621 total

includes taxes & fees

21 Sept - 22 Sept

A spacious lobby with a central seating area, a bar, and a reception desk.

3. Wingate Houston at Reliant Park & Medical Center

South Main

Terry

₹10,286 total

includes taxes & fees

17 Sept - 18 Sept

A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.

4. Candlewood Suites Houston Medical Center by IHG

South Main

Michelle

₹8,721 total

includes taxes & fees

21 Sept - 22 Sept

A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.

5. Quality Inn & Suites NRG Park - Medical Center

South Main

Oscar

₹7,758 total

includes taxes & fees

5 Oct - 6 Oct

A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

6. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

1.4 km from South Main

Kevin

₹13,270 total

includes taxes & fees

17 Sept - 18 Sept

A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

7. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Lamarr

₹14,274 total

includes taxes & fees

5 Oct - 6 Oct

8. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Kelly

₹15,093 total

includes taxes & fees

30 Sept - 1 Oct

A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.

9. Blossom Hotel Houston, Curio Collection by Hilton

Texas Medical Center, 3.5 km from South Main

Kamauri

₹17,456 total

includes taxes & fees

20 Sept - 21 Sept

An outdoor patio area with round wooden tables and wicker chairs, featuring a lantern and modern lighting fixtures.

10. Home2 Suites by Hilton Houston Medical Center, TX

Texas Medical Center, 4.7 km from South Main

Charles

₹14,580 total

includes taxes & fees

25 Sept - 26 Sept

A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

11. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Jorge

₹12,606 total

includes taxes & fees

16 Sept - 17 Sept

12. Hilton Garden Inn Houston Medical Center, TX

Texas Medical Center, 4.7 km from South Main

Tameka

₹12,743 total

includes taxes & fees

24 Sept - 25 Sept

A rooftop pool area with lounge chairs and a view of a tall building at night.

13. The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Kevin

₹16,287 total

includes taxes & fees

27 Sept - 28 Sept

A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.

14. Hotel Ylem

2.3 km from South Main

GUSTAVO

₹8,606 total

includes taxes & fees

22 Sept - 23 Sept

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

15. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Cindy

₹11,937 total

includes taxes & fees

11 Oct - 12 Oct

A modern living room with a glass table, a sofa, a TV, and a staircase with a city view.

16. DoubleTree by Hilton Hotel Houston - Greenway Plaza

Greenway Plaza-Upper Kirby, 6.6 km from South Main

mary lou

₹9,993 total

includes taxes & fees

24 Sept - 25 Sept

A hotel room with a sofa, ottoman, desk, and a bed.

17. Hyatt Place Houston/Galleria

8.7 km from South Main

Adaobi

₹12,250 total

includes taxes & fees

20 Sept - 21 Sept

A person sitting on a white lounge chair with a striped towel, reading a book.

18. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Greenway Plaza-Upper Kirby, 6.5 km from South Main

Lanita

₹7,983 total

includes taxes & fees

17 Sept - 18 Sept

A modern hotel lobby with a fireplace, seating area, and a decorative ceiling.

19. Homewood Suites by Hilton Houston Memorial

16.4 km from South Main

Roland

₹11,036 total

includes taxes & fees

11 Oct - 12 Oct

A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.

20. Home2 Suites by Hilton at the Galleria

Greater Uptown, 8 km from South Main

audra

₹11,827 total

includes taxes & fees

20 Sept - 21 Sept

View all properties

Compare popular hotels in South Main

Property	Property class	Guest rating
Comfort Suites Houston near Medical Center- NRG Stadium	2.5 star property	8.8 1000 1,000 reviews	View
Wyndham Houston at Reliant Park & Medical Center	3.5 star property	7.2 1405 1,405 reviews	View
Candlewood Suites Houston Medical Center by IHG	2.5 star property	7.4 897 897 reviews	View
Quality Inn & Suites NRG Park - Medical Center	2.5 star property	6.6 1003 1,003 reviews	View
Wingate Houston at Reliant Park & Medical Center	3.0 star property	6.6 1001 1,001 reviews	View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

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A person walking in front of a building with a brick facade and three arched windows.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

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A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

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An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

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A large rectangular reflecting pool with a tall building in the background.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

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Top South Main Hotel Reviews

Hyatt Regency Houston West

8/10 Good

"Very nice place to stay! Parking was a little confusing at first but once you figure it out it was great. Suggestion find parking in the covered area and the entry is the double glass doors. Unless you prefer the valet."

Search Hotels in South Main, Houston

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

2. Comfort Suites Houston near Medical Center- NRG Stadium

3. Wingate Houston at Reliant Park & Medical Center

4. Candlewood Suites Houston Medical Center by IHG

5. Quality Inn & Suites NRG Park - Medical Center

6. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

7. Hyatt Place Houston Medical Center

8. Hyatt House Houston Medical Center

9. Blossom Hotel Houston, Curio Collection by Hilton

10. Home2 Suites by Hilton Houston Medical Center, TX

11. Courtyard By Marriott Houston Medical Center Reliant Park

12. Hilton Garden Inn Houston Medical Center, TX

13. The Westin Houston Medical Center/Museum District

14. Hotel Ylem

15. Hilton Houston Plaza/Medical Center

16. DoubleTree by Hilton Hotel Houston - Greenway Plaza

17. Hyatt Place Houston/Galleria

18. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

19. Homewood Suites by Hilton Houston Memorial

20. Home2 Suites by Hilton at the Galleria

Compare popular hotels in South Main

Where to stay in South Main

Downtown Houston

The Galleria

Texas Medical Center

Montrose

Houston Central Business District

Top South Main Hotel Reviews

Hyatt Regency Houston West

Frequently asked questions

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