Aerial view of Hermann park in Houston with Japanese Garden, zoo, Space Adventure playground

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Our top choices for South Main hotels

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,010 reviews)
"Good parking"
United States
joseph
The price is ₹6,763
₹7,912 total
includes taxes & fees
12 Jul - 13 Jul
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,296 reviews)
"Would stay again!"
United States
Austin
The price is ₹9,159
₹10,716 total
includes taxes & fees
6 Jul - 7 Jul
Wyndham Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,005 reviews)
"Very clean rooms and excellent staff"
United States
Efrain
The price is ₹6,082
₹7,116 total
includes taxes & fees
12 Jul - 13 Jul
Quality Inn & Suites NRG Park - Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,010 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
United States
Cleota
The price is ₹9,832
₹11,503 total
includes taxes & fees
10 Jul - 11 Jul
Comfort Suites Houston near Medical Center- NRG Stadium

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (869 reviews)
"My stay was perfect "
United States
Fredrick
The price is ₹7,038
₹8,235 total
includes taxes & fees
12 Jul - 13 Jul
Candlewood Suites Houston Medical Center by IHG

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (112 reviews)
"Awesome staff, clean rooms and love the free parking! Thanks a lot for a great stay!"
United States
Rorie
The price is ₹6,315
₹7,388 total
includes taxes & fees
6 Jul - 7 Jul
Studio 6 Houston, TX – Pearland/Medical Center

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.0 out of 10, Very good, (2,121 reviews)
"Great Hotel!"
United States
Alexa
The price is ₹8,047
₹9,414 total
includes taxes & fees
7 Jul - 8 Jul
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
31.4 km from South Main
6.8 out of 10, (1,193 reviews)
"Great, great , great"
United States
Joshua
The price is ₹4,632
₹5,419 total
includes taxes & fees
9 Jul - 10 Jul
GreenTree Inn Houston IAH Airport

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (285 reviews)
"Clean room, and very helpful staff actually enjoyed our stay"
United States
Jessica
The price is ₹7,533
₹8,812 total
includes taxes & fees
12 Jul - 13 Jul
Best Western Plus Pearland/Houston Medical Center Hotel

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,224 reviews)
"Great location"
United States
Maxwell
The price is ₹8,004
₹9,204 total
includes taxes & fees
5 Jul - 6 Jul
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,914 reviews)
"Close to the airport and near many restaurants."
United States
Lori
The price is ₹8,498
₹9,996 total
includes taxes & fees
10 Jul - 11 Jul
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Platinum Inn & Suites Webster

Platinum Inn & Suites Webster
3.0 star property
30.8 km from South Main
7.8 out of 10, Good, (1,011 reviews)
"Clean and spacious rooms Helpful staff Good location"
United States
Julian
The price is ₹7,296
₹8,537 total
includes taxes & fees
1 Jul - 2 Jul
Platinum Inn & Suites Webster

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
3.0 star property
28.8 km from South Main
8.6 out of 10, Excellent, (721 reviews)
"It was clean and the staff was helpful."
United States
Yuan Chao
The price is ₹4,725
₹5,434 total
includes taxes & fees
11 Jul - 12 Jul
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown

Heritage Place Houston Brookhollow

Heritage Place Houston Brookhollow
3.0 star property
15.4 km from South Main
8.6 out of 10, Excellent, (1,038 reviews)
"Great stay, great place!"
United States
Jarvis
The price is ₹11,220
₹13,198 total
includes taxes & fees
21 Jun - 22 Jun
Heritage Place Houston Brookhollow

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,012 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
United States
Deanndra
The price is ₹8,170
₹9,559 total
includes taxes & fees
6 Jul - 7 Jul
Tru by Hilton Houston Webster NASA

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.0 out of 10, Wonderful, (42 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is ₹6,934
₹8,112 total
includes taxes & fees
16 Jul - 17 Jul
Hotel Royale

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,818 reviews)
"I had a great stay"
United States
Datroynard
The price is ₹12,854
₹15,040 total
includes taxes & fees
9 Jul - 10 Jul
SpringHill Suites by Marriott Houston Intercontinental Arprt

Hyatt Place Houston/Sugar Land

Hyatt Place Houston/Sugar Land
3.0 star property
21.4 km from South Main
8.8 out of 10, Excellent, (1,924 reviews)
"Really nice aria for waking around, quite neighborhood, friendly staff and good breakfast."
United States
Anam
The price is ₹13,415
₹15,426 total
includes taxes & fees
7 Jul - 8 Jul
Hyatt Place Houston/Sugar Land

Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport
3.0 star property
31.1 km from South Main
8.4 out of 10, Very good, (1,013 reviews)
"Close to the Airport and great service"
United States
Robert
The price is ₹9,629
₹11,326 total
includes taxes & fees
10 Jul - 11 Jul
Hilton Garden Inn Houston/Bush Intercontinental Airport

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,021 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
United States
Albert
The price is ₹8,275
₹9,682 total
includes taxes & fees
6 Jul - 7 Jul
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,010 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.2
Good
1,296 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
869 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,010 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,005 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveller data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers a restaurant and an outdoor pool.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 66 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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