Search Hotels in South Main, Houston
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,291 reviews)
"Hotel clean and convenient "
Mitzi
The price is ₹9,485
₹11,097 total
includes taxes & fees
17 May - 18 May
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is ₹6,744
₹7,890 total
includes taxes & fees
15 May - 16 May
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Great location"
Jeremy
The price is ₹7,493
₹8,767 total
includes taxes & fees
17 May - 18 May
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,003 reviews)
"Really clean and friendly staff 10/10 would definitely stay again!"
Gisselle
The price is ₹8,261
₹9,665 total
includes taxes & fees
31 May - 1 Jun
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (857 reviews)
"Kitchen fully equipped "
Royale
The price is ₹6,165
₹7,213 total
includes taxes & fees
24 May - 25 May
La Quinta Inn & Suites by Wyndham Richmond-Sugarland
La Quinta Inn & Suites by Wyndham Richmond-Sugarland30.3 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Everything was great parking food clean everything was awesome"
Sergio
The price is ₹8,949
₹10,291 total
includes taxes & fees
3 May - 4 May
Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar Land21.4 km from South Main
8.8 out of 10, Excellent, (1,849 reviews)
"Excellent breakfast and property was very clean!"
Brett
The price is ₹10,897
₹12,532 total
includes taxes & fees
3 May - 4 May
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,202 reviews)
"Super clean and close to the AirPort "
Keiry
The price is ₹11,866
₹13,883 total
includes taxes & fees
2 May - 3 May
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,159 reviews)
"Friendly staffs clean room good location "
Adeyemi
The price is ₹7,982
₹9,179 total
includes taxes & fees
5 May - 6 May
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (51 reviews)
"Great place! Very clean"
Donnette
The price is ₹6,297
₹7,368 total
includes taxes & fees
13 May - 14 May
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (780 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
David
The price is ₹7,579
₹8,565 total
includes taxes & fees
14 May - 15 May
Hampton Inn Houston-Pearland
Hampton Inn Houston-Pearland15.7 km from South Main
8.6 out of 10, Excellent, (611 reviews)
"Nice and decent property. "
Sylvia
The price is ₹10,585
₹12,049 total
includes taxes & fees
28 May - 29 May
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (233 reviews)
"Great breakfast and good A/C. No swimming pool.
"
Summer
The price is ₹8,452
₹9,889 total
includes taxes & fees
21 May - 22 May
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (686 reviews)
"Amazing staff and breakfast"
Tiffany
The price is ₹5,122
₹5,890 total
includes taxes & fees
3 May - 4 May
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (30 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is ₹6,915
₹8,090 total
includes taxes & fees
4 May - 5 May
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,902 reviews)
"easy to get to airport and staff was friendly and very helpful!"
Kendra
The price is ₹8,201
₹9,595 total
includes taxes & fees
3 May - 4 May
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,729 reviews)
"Ideal hotel close to the airport. Good size rooms, comfy and decent breakfast selection "
Paul
The price is ₹9,601
₹11,233 total
includes taxes & fees
15 May - 16 May
Embassy Suites by Hilton Houston Energy Corridor
Embassy Suites by Hilton Houston Energy Corridor21 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean room,omg breakfast was so good and happy hour was great. Front desk staff was great "
Tamashia
The price is ₹14,534
₹17,005 total
includes taxes & fees
21 May - 22 May
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Everything was perfect and good and very clean"
Russell
The price is ₹7,662
₹8,965 total
includes taxes & fees
24 May - 25 May
Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (865 reviews)
"Breakfast offerings were limited, but overall, the stay was great. Beds were comfortable, room was clean, staff was friendly. Felt safe in our hotel and would gladly stay again."
Travis
The price is ₹10,155
₹11,881 total
includes taxes & fees
17 May - 18 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,003 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 857 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,291 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel Houston - Greenway Plaza
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- 5 Star Hotels in Houston
- 5 Star Hotels in The Galleria
- Hotels near Bayou Music Center
- Aparthotels in Bellaire
- Bellaire Hotels
- Hotels near Downtown Aquarium
- Hotels Suites in Downtown Houston
- Hotels with Airport Transfers in Downtown Houston
- Hotels with Balcony in Downtown Houston
- Hotels with Swimming Pool in Downtown Houston
- Hotels with smoking rooms in Downtown Houston
- Luxury Hotels in Downtown Houston
- Beach Resorts & in East Downtown Houston
- Cheap Hotels in East Downtown Houston
- Hotels near Fannin South Station
- Family-Friendly Hotels in Greenway Plaza-Upper Kirby
- Greenway Plaza-Upper Kirby Hotels
- Resorts in Hermann Park/Rice U Station
- Hotels near House of Blues Houston
- Aparthotels in Houston
- Castles in Houston
- Business Hotels in Houston Central Business District
- Cheap Hotels in Houston Convention District
- Hotels near Museums in Houston Convention District
- Romantic Hotels in Houston Convention District
- Wedding Hotels in Houston Convention District
- Guest Houses in Houston
- Holiday Parks in Houston
- Hostels in Houston
- Resorts in Houston
- Adults Only Resorts & in Houston
- Beach Resorts & in Houston
- Boutique Hotels in Houston
- Cheap Hotels in Houston
- Business Hotels in Houston
- Historic Hotels in Houston
- Hotels with a Bar in Houston
- Hotels with Views in Houston
- Hotels with Airport Transfers in Houston
- Hotels with Early Check-in in Houston
- Hotels with Entertainment in Houston
- Hotels with Parking in Houston
- Hotels with Hot Tubs in Houston
- Hotels with Indoor Pools in Houston
- Hotels with smoking rooms in Houston
- Luxury Hotels in Houston
- Pet-Friendly Hotels in Houston
- Ski Hotels in Houston
- Hotels with Waterpark in Houston
- Houston Hotels
- Hotels near Houston Methodist Hospital
- Motels in Houston
- Palaces in Houston
- Town Houses in Houston
- Hotels near Houston Zoo
- Hotels near Lakewood Church
- Cheap Hotels in Mahatma Gandhi District
- Mahatma Gandhi District Hotels
- Hotels near Main Street Theater - Rice Village
- Hotels near MD Anderson Cancer Center
- Hotels near Memorial Hermann Hospital/Houston Zoo Station
- Midtown Hotels
- Cheap Hotels in Missouri City
- Hotels with Views in Missouri City
- Hotels near Museum District Station
- Hotels near NRG Arena
- Hotels near NRG Astrodome
- Hotels near NRG Park
- Hotels near NRG Stadium
- Hotels near Rice Stadium
- Hotels near Rice University
- Hotels near Richmond Avenue
- Hotels near River Oaks Country Club
- Hotels near Sam Houston Park
- Hotels near Schlumberger Headquarters
- Hotels with Swimming Pool in South Main
- Guest Houses in Southwest Houston
- Beach Resorts & in Southwest Houston
- Cheap Hotels in Southwest Houston
- Cheap Hotels in Texas Medical Center
- Hotels Suites in Texas Medical Center
- Luxury Hotels in Texas Medical Center
- Texas Medical Center Hotels
- Business Hotels in The Galleria
- Hotels near Museums in The Galleria
- Hotels Suites in The Galleria
- Hotels with Early Check-in in The Galleria
- Hotels with Parking in The Galleria
- The Galleria Hotels
- Hotels near Toyota Center
- Hotels near Uptown Park