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9 Sept - 10 Sept
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Top Trending Hotels Near South Main, Houston

Wyndham Houston near NRG Park/Medical Center
Lobby

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1153)
"I use the app and its been really helpful for our trips we have planned so far."
The price is ₹8,562
₹10,017 total
includes taxes & fees
20 Sept - 21 Sept
Wyndham Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Gazebo

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (937)
"Love the convenience of being next to NRG Stadium but the hotel needs an upgrade. "
The price is ₹6,973
₹8,158 total
includes taxes & fees
10 Sept - 11 Sept
Wingate Houston near NRG Park/Medical Center
Quality Inn & Suites NRG Park - Medical Center
1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1000)
"Wonderful experience absolutely love my stay"
The price is ₹5,481
₹6,413 total
includes taxes & fees
22 Sept - 23 Sept
Quality Inn & Suites NRG Park - Medical Center
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (796)
"Room was clean and roomy. The toilet height was too low. Staff was friendly and professional."
The price is ₹6,885
₹8,055 total
includes taxes & fees
12 Sept - 13 Sept
Candlewood Suites Houston Medical Center by IHG
Hyatt Regency Houston/Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers

Hyatt Regency Houston/Galleria

4.0 star property
9.0 out of 10, Wonderful, (1041)
"It was a great stay"
The price is ₹12,622
₹14,870 total
includes taxes & fees
5 Oct - 6 Oct
Hyatt Regency Houston/Galleria
Hyatt Place Houston Medical Center
Lobby

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1955)
"Nice place to stay."
The price is ₹11,386
₹13,392 total
includes taxes & fees
14 Sept - 15 Sept
Hyatt Place Houston Medical Center
The Lancaster Hotel
Exterior

The Lancaster Hotel

4.0 star property
9.8 out of 10, Exceptional, (1010)
"This was a lovely property with attention to detail that made the stay extra special "
The price is ₹20,574
₹24,072 total
includes taxes & fees
11 Sept - 12 Sept
The Lancaster Hotel
Omni Houston Hotel
Interior

Omni Houston Hotel

4.0 star property
9.0 out of 10, Wonderful, (1008)
"Enjoyed the stay "
The price is ₹14,758
₹17,526 total
includes taxes & fees
28 Sept - 29 Sept
Omni Houston Hotel
Blossom Hotel Houston
Front of property

Blossom Hotel Houston

4.0 star property
9.0 out of 10, Wonderful, (3499)
"Amazing place and the hotel service was the best! Great hotel amenities! "
The price is ₹11,211
₹13,116 total
includes taxes & fees
9 Oct - 10 Oct
Blossom Hotel Houston
Hyatt Regency Houston West
Breakfast, lunch, brunch served; American cuisine, garden views

Hyatt Regency Houston West

3.5 star property
8.6 out of 10, Excellent, (1169)
"Nice rooms, plenty of food choices."
The price is ₹9,091
₹10,637 total
includes taxes & fees
5 Oct - 6 Oct
Hyatt Regency Houston West
Holiday Inn Express & Suites Houston – Downtown North by IHG
Exterior

Holiday Inn Express & Suites Houston – Downtown North by IHG

2.5 star property
9.2 out of 10, Wonderful, (569)
"The hotel is very clean and the staff is super friendly and helpful."
The price is ₹9,444
₹11,050 total
includes taxes & fees
22 Sept - 23 Sept
Holiday Inn Express & Suites Houston – Downtown North by IHG
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior detail

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.2 out of 10, Very good, (2501)
"Great stay "
The price is ₹10,269
₹12,099 total
includes taxes & fees
14 Sept - 15 Sept
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hyatt House Houston Medical Center
Lobby

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1103)
"Have stayed there many times"
The price is ₹11,386
₹13,392 total
includes taxes & fees
13 Sept - 14 Sept
Hyatt House Houston Medical Center
La Quinta Inn & Suites by Wyndham Houston Southwest
Exterior

La Quinta Inn & Suites by Wyndham Houston Southwest

3.0 star property
7.0 out of 10, Good, (1005)
"The room was cleaned every day and breakfast was very good. "
The price is ₹5,402
₹6,320 total
includes taxes & fees
11 Sept - 12 Sept
La Quinta Inn & Suites by Wyndham Houston Southwest
Haven Inn & Suites Downtown Houston
Premium bedding, desk, iron/ironing board, free WiFi

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1009)
"Was great stay."
Haven Inn & Suites Downtown Houston
The Royal Sonesta Houston Galleria
Exterior

The Royal Sonesta Houston Galleria

4.0 star property
8.4 out of 10, Very good, (1233)
"This hotel stay was the best highly recommended "
The price is ₹11,254
₹15,439 total
includes taxes & fees
10 Oct - 11 Oct
The Royal Sonesta Houston Galleria
Heights House Hotel - Houston Heights Downtown, an Ascend Collection Hotel
View from room

Heights House Hotel - Houston Heights Downtown, an Ascend Collection Hotel

3.0 star property
7.8 out of 10, Good, (1001)
"What a great place to stay. Super clean rooms, super kind staff. "
The price is ₹9,303
₹10,885 total
includes taxes & fees
5 Oct - 6 Oct
Heights House Hotel - Houston Heights Downtown, an Ascend Collection Hotel
Moxy Houston Downtown
Front of property – evening/night

Moxy Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (565)
"Friendly staff, clean rooms and atmosphere. "
The price is ₹9,444
₹11,256 total
includes taxes & fees
21 Sept - 22 Sept
Moxy Houston Downtown
DoubleTree by Hilton Hotel Houston - Greenway Plaza
Business centre

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4.0 star property
8.2 out of 10, Very good, (1151)
" Great hotel"
The price is ₹7,975
₹9,330 total
includes taxes & fees
21 Sept - 22 Sept
DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Daily buffet breakfast for a fee

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4.0 star property
8.2 out of 10, Very good, (421)
"Great stay, shuttle to MD Anderson very convenient, they let us check out 1 hour later to accommodate Dr appt. "
The price is ₹12,069
₹14,121 total
includes taxes & fees
21 Sept - 22 Sept
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green showing city views, modern architecture and a high-rise building

Downtown Houston

3 out of top 10 points of interest in this area

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

1 out of top 10 points of interest in this area

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston which includes a skyscraper and a city

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Menil Collection featuring interior views and art

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Top South Main Hotel Reviews

Hilton Americas-Houston

Hilton Americas-Houston

10/10 Excellent
"Great space if you want to relax. Amazing pool and overall very clean. "
Alexis 1-night trip
Posted 3 days ago
Hilton Americas-Houston

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Quality Inn & Suites NRG Park - Medical Center and Wyndham Houston near NRG Park/Medical Center.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 62 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.