What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center .

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 65 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

The Best Hotels in South Main, Houston - 2026 Updated Prices

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Our top choices for South Main hotels

Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

South Main

Javier

₹7,074 total

includes taxes & fees

5 Apr - 6 Apr

Wingate Houston near NRG Park/Medical Center

South Main

Jeremy

₹8,546 total

includes taxes & fees

24 Mar - 25 Mar

Premium bedding, pillow-top beds, in-room safe, individually decorated

Wyndham Houston near NRG Park/Medical Center

South Main

Judson

₹10,818 total

includes taxes & fees

24 Mar - 25 Mar

Candlewood Suites Houston Medical Center by IHG

South Main

Ryan

₹8,438 total

includes taxes & fees

5 Apr - 6 Apr

Individually decorated, individually furnished, desk, laptop workspace

Comfort Suites Houston near Medical Center- NRG Stadium

South Main

karen

₹10,939 total

includes taxes & fees

31 Mar - 1 Apr

Deluxe Single Room | Egyptian cotton sheets, premium bedding, pillow-top beds, desk

Palace Inn Blue Houston East Beltway 8

29.5 km from South Main

KENDRA

₹7,647 total

includes taxes & fees

16 Mar - 17 Mar

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

31.2 km from South Main

Noe Luis Renato

₹8,184 total

includes taxes & fees

30 Mar - 31 Mar

Best Western Plus Manvel Inn & Suites

22.6 km from South Main

David

₹8,347 total

includes taxes & fees

12 Apr - 13 Apr

GreenTree Inn Houston IAH Airport

31.4 km from South Main

Morris

₹5,725 total

includes taxes & fees

1 Apr - 2 Apr

Platinum Inn & Suites Webster

30.8 km from South Main

Brian

₹6,989 total

includes taxes & fees

23 Mar - 24 Mar

Desk, laptop workspace, blackout curtains, iron/ironing board

Sonesta Simply Suites Houston – NASA Clear Lake

31.8 km from South Main

Anne

₹5,950 total

includes taxes & fees

19 Mar - 20 Mar

Best Western Plus Pearland/Houston Medical Center Hotel

Southeast Houston, 10.2 km from South Main

Darrick

₹9,640 total

includes taxes & fees

23 Mar - 24 Mar

Heritage Place Houston Brookhollow

15.4 km from South Main

Bobby

₹6,462 total

includes taxes & fees

24 Mar - 25 Mar

Tru by Hilton Houston Webster NASA

30.7 km from South Main

Jennifer

₹8,695 total

includes taxes & fees

29 Mar - 30 Mar

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

18.5 km from South Main

Jeffery

₹8,947 total

includes taxes & fees

16 Mar - 17 Mar

Room, 2 Queen Beds, Accessible (3x3 Shower) | In-room safe, desk, laptop workspace, iron/ironing board

Spark by Hilton Houston Bush Intercontinental Airport

31.2 km from South Main

Michael

₹9,883 total

includes taxes & fees

3 Apr - 4 Apr

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

32 km from South Main

joseph

₹8,166 total

includes taxes & fees

29 Mar - 30 Mar

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

31.8 km from South Main

Patricia

₹10,335 total

includes taxes & fees

13 Apr - 14 Apr

Hampton Inn Houston I-10 East

20.4 km from South Main

Catherine

₹8,128 total

includes taxes & fees

29 Mar - 30 Mar

Prestige Inn

19.7 km from South Main

Paige

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Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Discovery Green featuring a high-rise building, a city and modern architecture

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

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The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

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Houston_TexasChildrensHospital_553248635389801905_9

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

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Taken in front of apartments.

#UrbanJungle

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

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Menil Collection featuring interior views

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

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Top South Main Hotel Reviews

The Royal Sonesta Houston Galleria

6/10 Okay

"Staff"

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4/10 Poor

"I was very disappointed in this Doubletree! The room had a musty smell and it desperately needs updating. The bathroom looked like it needed a deep cleaning. The bed was like sleeping on a brick. Don’t take a truck and try to park in the garage. The roof is so low it broke our antenna. We stayed 3 nights and the more we saw, the more we disliked. Pick another place! "

Heritage Place Houston Brookhollow

2/10 Terrible

"Building in terrible condition. Actually scary non- the less nothing happened but it’s give that vibe. Staff very nice what can they actually do. I had one wash rag upon check-in, didn’t even bother asking for another one after reading all the comments. I checked out 2 days early smh. I guess for the pricing this is what you get. Oh, no breakfast I’m guessing they stopped this??? Idk. But yea I’ll pay the after money next time! "

Hilton Houston North

6/10 Okay

"Hotel looks nice but there are issues in the rooms. Plate around shower head falling off wall. Toilet paper holder falling off wall, doesn’t hold toilet paper roll. Shelf in shower falling out of wall. Lamp shade in room fraying around edges. Some walls are gross and need wiped down. Bed is comfortable though."

Search Hotels in South Main, Houston

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Our top choices for South Main hotels

Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Comfort Suites Houston near Medical Center- NRG Stadium

Palace Inn Blue Houston East Beltway 8

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Best Western Plus Manvel Inn & Suites

GreenTree Inn Houston IAH Airport

Platinum Inn & Suites Webster

Sonesta Simply Suites Houston – NASA Clear Lake

Best Western Plus Pearland/Houston Medical Center Hotel

Heritage Place Houston Brookhollow

Tru by Hilton Houston Webster NASA

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Spark by Hilton Houston Bush Intercontinental Airport

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn Houston I-10 East

Prestige Inn

Where to stay in South Main

Downtown Houston

The Galleria

Texas Medical Center

Houston Central Business District

Montrose

Top South Main Hotel Reviews

The Royal Sonesta Houston Galleria

Frequently asked questions

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