Search Hotels in South Main, Houston
Change your mind
Be picky
Go beyond your typical stay in South Main
Check prices for these dates
Top Trending Hotels Near South Main, Houston

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG

La Quinta Inn & Suites by Wyndham Deer Park
La Quinta Inn & Suites by Wyndham Deer Park

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Where to stay in South Main

Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.
Top South Main Hotel Reviews

Hyatt Place Houston Downtown
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Houston neighborhoods
- Hotels in Downtown Houston
- Hotels in The Galleria
- Hotels in Texas Medical Center
- Hotels in Montrose
- Hotels in Houston Central Business District
- Hotels in Houston Heights
- Hotels in Washington Ave./ Memorial Park
- Hotels in Northside
- Hotels in Southeast Houston
- Hotels in Midtown
- Hotels in South Central Houston
- Hotels in Westchase
- Hotels in Atascocita
- Hotels in Northeast Houston
- Hotels in Houston Museum District
- Hotels in Greater Uptown
- Hotels in Clear Lake
- Hotels in North Houston
- Hotels in Nassau Bay
- Hotels in Memorial
Hotels near popular Houston Attractions
More accommodation types in South Main
Explore more hotels
- Blossom Hotel Houston
- Hyatt Place Houston Downtown
- Hyatt Regency Houston/Galleria
- Hyatt Regency Houston Downtown
- Hilton Houston Plaza/Medical Center
- The Westin Oaks Houston at the Galleria
- The Laura Hotel, Houston Downtown, Autograph Collection
- DoubleTree by Hilton Hotel Houston - Greenway Plaza
- Crowne Plaza Houston Med Ctr-Galleria Area by IHG
- Marriott Marquis Houston
- Hotel Zaza Houston Museum District
- SpringHill Suites by Marriott Houston Intercontinental Arprt
More ways to book
Expedia's Latest Trends
- Hotels in Lekhnath
- Hilton Garden Inn San Diego - Rancho Bernardo
- Luxury Hotels in New Delhi
- Secrets The Vine Cancun - Adults Only - All Inclusive
- Uday Suites
- Hotels in Addanki
- Amboseli Serena Safari Lodge
- Plaza Premium Lounge KLIA - Wellness Spa
- Treebo Premium Tahoora International
- Hotels near Madurai Junction Station
- NH Collection Maldives Reethi Resort
- Boutique Hotels in Chandigarh
- Hotels in Shimla
- Emirates Park Resort
- Flights to Bristol
- Flights from Mumbai (BOM) to South Bend (SBN)
- Flights from Kolkata (CCU) to Bhuj (BHJ)
- Flights from Kolkata (CCU) to Abha (AHB)
- Flights to Ghatshila
- Flights to Dhangadhi
- Flights from Hyderabad (HYD) to Leeds (LBA)
- Flights from Thiruvananthapuram (TRV) to Seattle (SEA)
- Flights from Armenia (AXM) to Ajnala (ATQ)