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Our top choices for South Main hotels

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,001 reviews)
"Courteous staff, clean room, quite property"
United States
Javier
The price is ₹6,046
₹7,074 total
includes taxes & fees
5 Apr - 6 Apr
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,006 reviews)
"Great location"
United States
Jeremy
The price is ₹7,304
₹8,546 total
includes taxes & fees
24 Mar - 25 Mar
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,242 reviews)
"Property was nice. "
United States
Judson
The price is ₹9,246
₹10,818 total
includes taxes & fees
24 Mar - 25 Mar
Wyndham Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (841 reviews)
"Room was clean. It had a musty smell though. "
United States
Ryan
The price is ₹7,212
₹8,438 total
includes taxes & fees
5 Apr - 6 Apr
Candlewood Suites Houston Medical Center by IHG

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,002 reviews)
"We had everything we needed. Staff was great"
United States
karen
The price is ₹9,349
₹10,939 total
includes taxes & fees
31 Mar - 1 Apr
Comfort Suites Houston near Medical Center- NRG Stadium

Palace Inn Blue Houston East Beltway 8

Palace Inn Blue Houston East Beltway 8
2.5 star property
29.5 km from South Main
9.0 out of 10, Wonderful, (372 reviews)
"Second time staying at this hotel, very friendly staff and clean rooms. Close to the highway, restaurants and movie theater. "
United States
KENDRA
The price is ₹6,650
₹7,647 total
includes taxes & fees
16 Mar - 17 Mar
Palace Inn Blue Houston East Beltway 8

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very good, (1,651 reviews)
"Nice and neat place to stay. Close to the airport, free shuttle."
Mexico
Noe Luis Renato
The price is ₹6,995
₹8,184 total
includes taxes & fees
30 Mar - 31 Mar
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Best Western Plus Manvel Inn & Suites

Best Western Plus Manvel Inn & Suites
2.5 star property
22.6 km from South Main
8.8 out of 10, Excellent, (767 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
United States
David
The price is ₹7,387
₹8,347 total
includes taxes & fees
12 Apr - 13 Apr
Best Western Plus Manvel Inn & Suites

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
31.4 km from South Main
6.6 out of 10, (1,042 reviews)
"Great"
United States
Morris
The price is ₹4,893
₹5,725 total
includes taxes & fees
1 Apr - 2 Apr
GreenTree Inn Houston IAH Airport

Platinum Inn & Suites Webster

Platinum Inn & Suites Webster
3.0 star property
30.8 km from South Main
7.8 out of 10, Good, (1,003 reviews)
"Was an overall great stay"
United States
Brian
The price is ₹5,973
₹6,989 total
includes taxes & fees
23 Mar - 24 Mar
Platinum Inn & Suites Webster

Sonesta Simply Suites Houston – NASA Clear Lake

Sonesta Simply Suites Houston – NASA Clear Lake
2.5 star property
31.8 km from South Main
8.2 out of 10, Very good, (1,005 reviews)
"Love this place "
United States
Anne
The price is ₹5,085
₹5,950 total
includes taxes & fees
19 Mar - 20 Mar
Sonesta Simply Suites Houston – NASA Clear Lake

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (167 reviews)
"Rooms where very cozy."
United States
Darrick
The price is ₹8,239
₹9,640 total
includes taxes & fees
23 Mar - 24 Mar
Best Western Plus Pearland/Houston Medical Center Hotel

Heritage Place Houston Brookhollow

Heritage Place Houston Brookhollow
3.0 star property
15.4 km from South Main
8.6 out of 10, Excellent, (801 reviews)
"Clean rooms good location and good value"
United States
Bobby
The price is ₹5,495
₹6,462 total
includes taxes & fees
24 Mar - 25 Mar
Heritage Place Houston Brookhollow

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Clean room, comfortable feeling, great staff "
United States
Jennifer
The price is ₹7,432
₹8,695 total
includes taxes & fees
29 Mar - 30 Mar
Tru by Hilton Houston Webster NASA

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,109 reviews)
"Great breakfast and staff was wonderful."
United States
Jeffery
The price is ₹7,780
₹8,947 total
includes taxes & fees
16 Mar - 17 Mar
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Spark by Hilton Houston Bush Intercontinental Airport

Spark by Hilton Houston Bush Intercontinental Airport
3.0 star property
31.2 km from South Main
8.6 out of 10, Excellent, (1,000 reviews)
"Room was absolutely stunning. It was clean and the bed was super comfortable! The wonderful lady who checked us in was sweet as can be !! Would definitely stay here again !! "
United States
Michael
The price is ₹8,447
₹9,883 total
includes taxes & fees
3 Apr - 4 Apr
Spark by Hilton Houston Bush Intercontinental Airport

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
3.5 star property
32 km from South Main
9.2 out of 10, Wonderful, (1,003 reviews)
"Beautiful room very comfortable."
United States
joseph
The price is ₹7,101
₹8,166 total
includes taxes & fees
29 Mar - 30 Mar
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,806 reviews)
"Nice places to stay while waiting for our next flight"
Canada
Patricia
The price is ₹8,786
₹10,335 total
includes taxes & fees
13 Apr - 14 Apr
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn Houston I-10 East

Hampton Inn Houston I-10 East
2.5 star property
20.4 km from South Main
8.8 out of 10, Excellent, (574 reviews)
"The staff were very friendly. The room was very clean. I would definitely stay here again."
United States
Catherine
The price is ₹6,947
₹8,128 total
includes taxes & fees
29 Mar - 30 Mar
Hampton Inn Houston I-10 East

Prestige Inn

Prestige Inn
2.5 star property
19.7 km from South Main
8.6 out of 10, Excellent, (310 reviews)
"Good staff"
United States
Paige
Prestige Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 65 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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