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Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,291 reviews)
"Hotel clean and convenient "
United States
Mitzi
The price is ₹9,485
₹11,097 total
includes taxes & fees
17 May - 18 May
Wyndham Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,001 reviews)
"Very clean rooms and excellent staff"
United States
Efrain
The price is ₹6,349
₹7,428 total
includes taxes & fees
29 May - 30 May
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,003 reviews)
"Great location"
United States
Jeremy
The price is ₹7,469
₹8,739 total
includes taxes & fees
24 May - 25 May
Wingate Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Really clean and friendly staff 10/10 would definitely stay again!"
United States
Gisselle
The price is ₹8,183
₹9,574 total
includes taxes & fees
24 May - 25 May
Comfort Suites Houston near Medical Center- NRG Stadium

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (857 reviews)
"Kitchen fully equipped "
United States
Royale
The price is ₹6,165
₹7,213 total
includes taxes & fees
24 May - 25 May
Candlewood Suites Houston Medical Center by IHG

La Quinta Inn & Suites by Wyndham Richmond-Sugarland

La Quinta Inn & Suites by Wyndham Richmond-Sugarland
3.0 star property
30.3 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Everything was great parking food clean everything was awesome"
United States
Sergio
The price is ₹9,030
₹10,384 total
includes taxes & fees
6 May - 7 May
La Quinta Inn & Suites by Wyndham Richmond-Sugarland

Hyatt Place Houston/Sugar Land

Hyatt Place Houston/Sugar Land
3.0 star property
21.4 km from South Main
8.8 out of 10, Excellent, (1,849 reviews)
"Excellent breakfast and property was very clean!"
United States
Brett
The price is ₹10,889
₹12,523 total
includes taxes & fees
3 May - 4 May
Hyatt Place Houston/Sugar Land

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,201 reviews)
"Super clean and close to the AirPort "
United States
Keiry
The price is ₹11,866
₹13,883 total
includes taxes & fees
1 May - 2 May
Courtyard by Marriott Houston Intercontinental Airport

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,161 reviews)
"Friendly staffs clean room good location "
United States
Adeyemi
The price is ₹7,982
₹9,179 total
includes taxes & fees
3 May - 4 May
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (51 reviews)
"Great place! Very clean"
United States
Donnette
The price is ₹6,277
₹7,345 total
includes taxes & fees
18 May - 19 May
Studio 6 Houston, TX – Pearland/Medical Center

Best Western Plus Manvel Inn & Suites

Best Western Plus Manvel Inn & Suites
2.5 star property
22.6 km from South Main
8.8 out of 10, Excellent, (780 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
United States
David
The price is ₹7,554
₹8,536 total
includes taxes & fees
13 May - 14 May
Best Western Plus Manvel Inn & Suites

Hampton Inn Houston-Pearland

Hampton Inn Houston-Pearland
2.5 star property
15.7 km from South Main
8.6 out of 10, Excellent, (610 reviews)
"Nice and decent property. "
United States
Sylvia
The price is ₹10,585
₹12,049 total
includes taxes & fees
28 May - 29 May
Hampton Inn Houston-Pearland

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (233 reviews)
"Great breakfast and good A/C. No swimming pool. "
United States
Summer
The price is ₹8,452
₹9,889 total
includes taxes & fees
19 May - 20 May
Best Western Plus Pearland/Houston Medical Center Hotel

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
3.0 star property
28.8 km from South Main
8.6 out of 10, Excellent, (686 reviews)
"Amazing staff and breakfast"
United States
Tiffany
The price is ₹5,122
₹5,890 total
includes taxes & fees
3 May - 4 May
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.0 out of 10, Wonderful, (30 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is ₹6,915
₹8,090 total
includes taxes & fees
1 May - 2 May
Hotel Royale

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very good, (1,899 reviews)
"easy to get to airport and staff was friendly and very helpful!"
United States
Kendra
The price is ₹8,304
₹9,716 total
includes taxes & fees
7 May - 8 May
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,728 reviews)
"Ideal hotel close to the airport. Good size rooms, comfy and decent breakfast selection "
United Kingdom
Paul
The price is ₹11,171
₹13,070 total
includes taxes & fees
8 May - 9 May
SpringHill Suites by Marriott Houston Intercontinental Arprt

Embassy Suites by Hilton Houston Energy Corridor

Embassy Suites by Hilton Houston Energy Corridor
3.5 star property
21 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean room,omg breakfast was so good and happy hour was great. Front desk staff was great "
United States
Tamashia
The price is ₹14,488
₹16,951 total
includes taxes & fees
29 May - 30 May
Embassy Suites by Hilton Houston Energy Corridor

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Breakfast was great"
United States
Tracy
The price is ₹7,738
₹9,053 total
includes taxes & fees
24 May - 25 May
Tru by Hilton Houston Webster NASA

Home2 Suites by Hilton Houston Pasadena

Home2 Suites by Hilton Houston Pasadena
3.0 star property
24.3 km from South Main
9.4 out of 10, Exceptional, (865 reviews)
"Breakfast offerings were limited, but overall, the stay was great. Beds were comfortable, room was clean, staff was friendly. Felt safe in our hotel and would gladly stay again."
United States
Travis
The price is ₹10,159
₹11,886 total
includes taxes & fees
17 May - 18 May
Home2 Suites by Hilton Houston Pasadena
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,003 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
857 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,291 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,003 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,001 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveller data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers a restaurant and an outdoor pool.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 66 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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