What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to Reliant Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on our traveller data, Wyndham Houston at Reliant Park & Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from Reliant Park, and it offers a restaurant and an outdoor pool.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

Reliant Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as Reliant Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

The Best Hotels in South Main, Houston - 2026 Updated Prices

A city skyline with modern buildings and a park with a lake.

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Our top choices for South Main hotels

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

1. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

Tamy

₹10,028 total

includes taxes & fees

5 Nov - 6 Nov

A modern lobby with a blue carpet, seating area, and large windows.

2. Wyndham Houston at Reliant Park & Medical Center

South Main

Matthew

₹13,638 total

includes taxes & fees

4 Nov - 5 Nov

A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.

3. Quality Inn & Suites NRG Park - Medical Center

South Main

Jasmine

₹7,145 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a central seating area, a bar, and a reception desk.

4. Wingate Houston near Reliant Park/Medical Center

South Main

Crystal

₹9,916 total

includes taxes & fees

15 Nov - 16 Nov

A hotel with a prominent 'Candlewood Suites' sign, multiple windows, and a well-lit entrance.

5. Candlewood Suites Houston Medical Center by IHG

South Main

Olga

₹8,691 total

includes taxes & fees

17 Nov - 18 Nov

A modern living room with a grey sofa, a coffee table, and a large window with a view of the outside.

6. 3 BR Condo near Reliant/NRG Stadium

South Main

Jeffrey

₹35,440 total

includes taxes & fees

12 Nov - 13 Nov

A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

1.4 km from South Main

Francisco

₹13,209 total

includes taxes & fees

8 Nov - 9 Nov

A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

8. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Christina

₹14,134 total

includes taxes & fees

26 Nov - 27 Nov

A modern interior with a vertical garden wall and a sign reading "ESPERANTO".

9. Hotel Ylem

2.3 km from South Main

aundrea

₹8,316 total

includes taxes & fees

10 Nov - 11 Nov

10. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Debra

₹14,151 total

includes taxes & fees

6 Nov - 7 Nov

A hotel pool area with a bar, seating, and a view of the building's exterior.

11. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Asif

₹11,044 total

includes taxes & fees

22 Nov - 23 Nov

A modern building with a sign reading 'INTERCONTINENTAL' and 'SAFINA MEDITERRANEAN'.

12. InterContinental Houston by IHG

Texas Medical Center, 4.1 km from South Main

Luke

₹19,620 total

includes taxes & fees

29 Nov - 30 Nov

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

13. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Stephen

₹8,635 total

includes taxes & fees

29 Nov - 30 Nov

A hotel pool area with a pool, lounge chairs, and umbrellas.

14. Hilton Garden Inn Houston-Pearland

10.6 km from South Main

Julia Hurtado

₹9,513 total

includes taxes & fees

22 Nov - 23 Nov

A reception area with a wooden reception desk, two refrigerators, and clocks displaying different city names.

15. Best Western Plus Pearland/Houston Medical Center Hotel

Southeast Houston, 10.2 km from South Main

AYTUNC

₹9,025 total

includes taxes & fees

1 Nov - 2 Nov

A high-rise hotel with a modern design, featuring a central courtyard with palm trees and a swimming pool.

16. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

8.9 km from South Main

Jennifer

₹12,591 total

includes taxes & fees

27 Nov - 28 Nov

An outdoor seating area with tables and chairs, a brick floor, and a building with large windows and a glass door.

17. Holiday Inn Express & Suites Stafford NW - Sugar Land by IHG

16.1 km from South Main

Jessica Monica

₹10,185 total

includes taxes & fees

28 Nov - 29 Nov

A hotel room with a sofa, ottoman, desk, and a bed.

18. Hyatt Place Houston/Galleria

8.7 km from South Main

Katrina

₹12,876 total

includes taxes & fees

22 Nov - 23 Nov

A hotel entrance with a modern design, a covered walkway, and a car parked outside.

19. The Royal Sonesta Houston Galleria

The Galleria, 8.8 km from South Main

artur

₹14,373 total

includes taxes & fees

22 Nov - 23 Nov

A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.

20. Home2 Suites by Hilton at the Galleria

Greater Uptown, 8 km from South Main

Franchansca

₹11,772 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Compare popular hotels in South Main

Property	Property class	Guest rating
Comfort Suites Houston near Medical Center- NRG Stadium	2.5 star property	8.8 Excellent 1,014 reviews	View
Candlewood Suites Houston Medical Center by IHG	2.5 star property	7.4 Good 901 reviews	View
Wyndham Houston at Reliant Park & Medical Center	3.5 star property	7.2 Good 1,488 reviews	View
Quality Inn & Suites NRG Park - Medical Center	2.5 star property	6.6 1,000 reviews	View
Wingate Houston near Reliant Park/Medical Center	3.0 star property	6.6 1,005 reviews	View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

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A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

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A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

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A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

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A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

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Top South Main Hotel Reviews

Hilton Houston Plaza/Medical Center

10/10 Excellent

"Great hotel. My room was very clean. Bar/restaurant on site with reasonable prices. Front staff is very friendly and very accommodating. They have a breakfast buffet for I think $16-19. Starbucks coffee on site."

Search Hotels in South Main, Houston

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Our top choices for South Main hotels

1. Comfort Suites Houston near Medical Center- NRG Stadium

2. Wyndham Houston at Reliant Park & Medical Center

3. Quality Inn & Suites NRG Park - Medical Center

4. Wingate Houston near Reliant Park/Medical Center

5. Candlewood Suites Houston Medical Center by IHG

6. 3 BR Condo near Reliant/NRG Stadium

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

8. Hyatt Place Houston Medical Center

9. Hotel Ylem

10. Hyatt House Houston Medical Center

11. Courtyard By Marriott Houston Medical Center Reliant Park

12. InterContinental Houston by IHG

13. Hilton Houston Plaza/Medical Center

14. Hilton Garden Inn Houston-Pearland

15. Best Western Plus Pearland/Houston Medical Center Hotel

16. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

17. Holiday Inn Express & Suites Stafford NW - Sugar Land by IHG

18. Hyatt Place Houston/Galleria

19. The Royal Sonesta Houston Galleria

20. Home2 Suites by Hilton at the Galleria

Compare popular hotels in South Main

Where to stay in South Main

Downtown Houston

The Galleria

Texas Medical Center

Montrose

Houston Central Business District

Top South Main Hotel Reviews

Hilton Houston Plaza/Medical Center

Frequently asked questions

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