South Main Travel Guide
Houston
Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art galleries and great live music in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art galleries and lively festivals in this vibrant area.
Rice University
Walk around the campus of Rice University, a top university in Houston. Experience the area's acclaimed art galleries and great live music.
Top hotels in South Main
Wyndham Houston near NRG Park/Medical Center
Property is older, but it was convenient and not a bad place to stay.
Reviewed on 29 Apr 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Highly recommended
Reviewed on 30 Apr 2026
Club Quarters Hotel Downtown, Houston
Hotel is in a good location. The building is definitely dated. It is obvious they try to maintain it the best they can. The only complaint was the smell perhaps due to the pet policy. However, for the price it was tolerable.
Reviewed on 30 Apr 2026
The Whitehall Houston
The "presidential suite" was disgusting. The bahtroom tiles were all cracked and some paint or something olds residue was on it I can suppoly pictures and the valet was rude. Also restaurant was closed when needed. Wont book here again.
Reviewed on 30 Apr 2026
Blossom Hotel Houston, Curio Collection by Hilton
Very clean and near Medical Center.
Reviewed on 30 Apr 2026
Hilton Houston Plaza/Medical Center
Parking garage is just plan nasty/filthy, AC was not working properly.
Reviewed on 30 Apr 2026
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Arena, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Continental Club or Children's Museum of Houston and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travellers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
