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Top Luxury Eastern Tennessee Hotels

Carnegie Hotel & Spa

1216 W State Of Franklin Rd Johnson City TN

2 hours drive from Great Smoky Mountains National Park

Stay at this spa hotel in Johnson City. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the restaurant and the helpful staff in their ...

9.8/10 Exceptional! (1,402 reviews)

This is a lovely hotel and we really enjoyed it! The bar is beautiful!

Reviewed on 11 May 2026

THE TENNESSEAN Hotel

531 Henley Street Knoxville TN

55 min drive from Great Smoky Mountains National Park

Stay at this luxury hotel in Knoxville. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...

9.6/10 Exceptional! (1,017 reviews)

Great stay as usual

Reviewed on 11 May 2026

The Read House Hotel

107 West Martin Luther King Blvd Chattanooga TN

4 hours drive from Great Smoky Mountains National Park

Stay at this business-friendly hotel in Chattanooga. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean ...

9.4/10 Exceptional! (2,470 reviews)

Everything was great when I visited. If I want to make a fuss about anything, the pool wasn’t heated. Room service and staff get 5 stars from me.

Reviewed on 11 May 2026

See all 26,210 properties in Eastern Tennessee

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.