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Top Luxury Eastern Tennessee Hotels

Carnegie Hotel & Spa

1216 W State Of Franklin Rd Johnson City TN

2 hours drive from Great Smoky Mountains National Park

Stay at this spa hotel in Johnson City. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the restaurant and the helpful staff in their ...

9.6/10 Exceptional! (1,338 reviews)

Love the hotel and the free sauna!

Reviewed on 3 Feb 2026

THE TENNESSEAN Hotel

531 Henley Street Knoxville TN

55 min drive from Great Smoky Mountains National Park

Stay at this luxury hotel in Knoxville. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...

9.4/10 Exceptional! (1,000 reviews)

everything was perfect thanks

Reviewed on 3 Feb 2026

The Read House Hotel

107 West Martin Luther King Blvd Chattanooga TN

4 hours drive from Great Smoky Mountains National Park

Stay at this business-friendly hotel in Chattanooga. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean ...

9.4/10 Exceptional! (2,354 reviews)

The hotel staff was very accommodating on all fronts, and always had water available. The room was clean and well set up, the hvac was quiet and effective, and the bed was comfortable. Only negative was that the peloton bike in the gym had not been maintained, the screen did not turn on and the bike ...

Reviewed on 29 Jan 2026

See all 25,985 properties in Eastern Tennessee

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.