Eastern Tennessee Luxury Holidays 2026

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Top Luxury Eastern Tennessee Hotels

Carnegie Hotel & Spa

1216 W State Of Franklin Rd Johnson City TN

2 hours drive from Great Smoky Mountains National Park

Stay at this spa hotel in Johnson City. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the restaurant and the helpful staff in their ...

9.8/10 Exceptional! (1,437 reviews)

"Absolutely beautiful hotel - wonderfully decorated with many amazing, historic pieces - a real gem in a great little city"

Reviewed on 15 Aug 2026

THE TENNESSEAN Hotel

531 Henley Street Knoxville TN

55 min drive from Great Smoky Mountains National Park

Stay at this luxury hotel in Knoxville. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...

The Read House Hotel

107 West Martin Luther King Blvd Chattanooga TN

4 hours drive from Great Smoky Mountains National Park

Stay at this business-friendly hotel in Chattanooga. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean ...

9.6/10 Exceptional! (2,589 reviews)

"Everything there was first class I tried everything except the breakfast room very clean staff excellent"

Reviewed on 18 Aug 2026

See all 27,182 properties in Eastern Tennessee

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.