The Best Hotels in Santa Lucia, Syracuse - 2026 Updated Prices

A bridge over a turquoise waterfront with boats docked, surrounded by historic buildings.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.

A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

See properties

Ancient ruins with a large amphitheater surrounded by trees.

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

See properties

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

See properties

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

See properties

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

See properties

Top Santa Lucia Hotel Reviews

Lanterne Magiche Ortigia

10/10 Excellent

"Great location. The hotel was wonderful! Clean and beautiful. Close to center and sea. Our room was spacious and great sea view!"

Grand Hotel Ortigia Siracusa

10/10 Excellent

"I enjoyed four unforgettable days exploring beautiful Ortigia -staying at the Grand Hotel Ortigia, which is a 5-star luxury hotel overlooking the harbor. It is just a short stroll to the must-see landmarks such as the ruins of the Temple of Apollo, the Aretusa Fountain, and the renowned Cathedral of Syracuse. it was built in 1890 and was completely renovated while preserving its classic old-world charm with marble floors, Corinthian columns, and beautiful art-filled common areas. They have an upscale rooftop restaurant and lounge on the third floor, which serves a sumptuous breakfast buffet and has great outdoor seating with spectacular views. I went up to the terrace one evening to enjoy the sunset with an Aperol Spritz and some nibbles and, after the sun went down, an exceptionally talented young man beautifully played his violin serenading the guests. Parking in the old city is a challenge, and not for the faint of heart. But the hotel does have a small lot nearby, but which seemed to stay full and was hard to find. With the helpful staff, I was able to register my rental car to allow me to drive to hotel which is in the restricted tourist zone and I moved my car to their lot one evening once the crowds had dissipated a bit. The staff couldn’t have been more helpful and even helped arrange a small group boat tour. This hotel truly deserves its name the Grand Hotel Ortigia Siracusa!"

Mangia's Brucoli, Sicily, Autograph Collection

10/10 Excellent

"Staying will be an extremely fond memory for my wife and I. After the first night, we both decided to make our stay here our official honeymoon. The view from our room allowed for an incredible view of Mt Etna. The staff is professional and polite and very friendly. The breakfast buffet is pretty outstanding with so many options. Unfortunately, we didn’t get to try the other restaurants but we were able to take advantage of the Lime Bar before leaving. They absolutely captured Sicily’s beautiful culture and atmosphere. We absolutely recommend staying at Mangia, hands down, with zero hesitation."

Fortaleza Charme House

10/10 Excellent

"The hotel is quite cool - looks unimpressive from the outside but inside the rooms are very modern and clean. We had 2 rooms on the top floor with skylights which had remote-controlled shades. We were given code access to get in - which was perfect as we arrived early and dropped our bags off. We were lucky to fin street parking just across the street from the hotel. The location was awesome. Right next to the bridge to Ortigia. Plenty of coffee shops and restaurants near by. The staff provided helpful recommendations and was very accommodating. We would highly recommend the hotel."

Frequently asked questions

What is Santa Lucia like?

Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.

Where is the best hotel for a stay in Santa Lucia?

Based on our traveller data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.

How many hotels will I find in Santa Lucia?

Expedia has 313 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.

What are the top things to see and do in Santa Lucia?

Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

Explore a world of travel with Expedia

Book Hotels in Santa Lucia on Expedia.it

Search Hotels in Santa Lucia, Syracuse

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Santa Lucia hotels

1. Grande Albergo Alfeo

2. Nostos rooms & Apartments

3. Caportigia Boutique Hotel

4. Hotel Palazzo Cavalieri

5. Fortaleza Charme House

6. Lakkios

7. Casa Miranda Boutique

8. Syraka Design Rooms & Suites

9. Melody rooms

10. B&B Nike

11. Giuggiulena Villa

12. San Nicola Rooms Siracusa

13. Re Dionisio Luxury Suites

14. Regina Margherita

15. B&B Siracusa

16. Calafatari B&B

17. Gymnasium

18. B&B IL MORO

19. AmaCasa Siracusa

20. Residence Agatocle

Where to stay in Santa Lucia

Ortigia

Neapolis

Grottasanta

Tiche

Acradina

Top Santa Lucia Hotel Reviews

Lanterne Magiche Ortigia

Frequently asked questions

Explore a world of travel with Expedia