Midtown Travel Guide
St. Louis
Popular places to visit
St. Louis University
Explore the campus of St. Louis University during your stay in St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theatre scene.
Scott Joplin House State Historic Site
Learn about the local history of St. Louis when you take a trip to Scott Joplin House State Historic Site. Experience the area's acclaimed theatre scene or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.
St. Louis Union Station
You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.
Gateway Arch
Visit the Museum of Westward Expansion, then ascend to the top of the tallest man-made monument in the US for breathtaking views of St. Louis.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Top hotels in Midtown
Residence Inn by Marriott St Louis Downtown
industrial park location, lots of trucks and trains nearby, stayed for 5 nights but only had maid service on one day. had to request more towels and shampoo and get it myself. loud HVAC system.
Reviewed on 27 Apr 2026
Element St. Louis Midtown
It was okay.
Reviewed on 7 May 2026
Hyatt Regency St. Louis at The Arch
Very clean
Reviewed on 8 May 2026
Clayton Plaza Hotel & Extended Stay
Staff were all excellent. The daytime front desk lady (had yorkie puppy) was above excellent in friendly, helpful and kindness. She is an asset to your hotel.
Reviewed on 7 May 2026
21C Museum Hotel St Louis
Really cool hotel with great onsite bar/restaurant, gym, pool and art gallery.
Reviewed on 6 May 2026
Drury Plaza Hotel St. Louis at the Arch
This is a perfect location for visiting the Gateway Arch, a block away, and only a few blocks from the Metrolink. The included beer/wine light dinner menu in the evening means you don’t have to go out at night after a long day of sightseeing.
Reviewed on 7 May 2026
Other neighbourhoods around Midtown
The Gate
While The Gate may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like St. Louis Union Station and Busch Stadium.
Downtown West
While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.
Lafayette Square
The restaurants and shopping are a few reasons travellers visit Lafayette Square. Want to see more of the surrounding area? St. Louis Union Station and Busch Stadium are a few top sights nearby.
The Grove
While there might not be top attractions in The Grove, you can explore the larger area and discover places like St. Louis Zoo and St. Louis Science Center.
Shaw
Shaw might not have many top sights, but Missouri Botanical Gardens and Arboretum and St. Louis Science Center are two attractions nearby that you can check out.
Central West End
If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.
