What is Midtown like?

Travellers are sure to enjoy a stay in St. Louis's Midtown neighbourhood. Make sure that you visit Chaifetz Arena and Washington Avenue Historic District as part of your Midtown travel plans.

Where is the best place to stay in Midtown?

Based on our traveller data, Element by Marriott St. Louis Midtown is one of the top choices for your stay in Midtown. This hotel is a short 6-minute walk from St. Louis University, and it offers free breakfast and an indoor pool.

How many hotels will I be able to find in the Midtown area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 36 Midtown hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Midtown, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of check in. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to get top deals in Midtown.

What are the top things to see and do in Midtown?

Sights like Red Flag, Scott Joplin House State Historic Site and Museum of Contemporary Religious Art can be part of your cultural tour of Midtown. Chaifetz Arena and Washington Avenue Historic District are also a couple of places to visit in the neighbourhood. St. Louis Union Station, Hermann Stadium and .ZACK Theater are just a few of the places to visit in and around Midtown. While you're out sightseeing, Fubar and The Sovereign - St. Louis are a couple of additional sights to visit in St. Louis.

How can I get around Midtown and the greater St. Louis area?

Ready to get out and explore the city? Grand Station is the closest metro station.

The Best Hotels in Midtown, St. Louis - 2026 Updated Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Midtown hotels

An outdoor patio area with seating, planters, and a grill.

1. Element by Marriott St. Louis Midtown

Midtown

Julie

₹15,877 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio area with seating, a fire pit, and a grill.

2. Residence Inn by Marriott St Louis Downtown

Midtown

Patrick

₹12,422 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor seating area with multiple tables and chairs, large umbrellas, and a built-in fire feature against a stone wall.

3. Fairfield Inn & Suites by Marriott St. Louis Downtown

Downtown West, 1.3 km from Midtown

Demarco

₹13,373 total

includes taxes & fees

22 Nov - 23 Nov

A rooftop terrace with outdoor seating, string lights, and a city skyline view.

4. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

0.8 km from Midtown

Skylee

₹11,572 total

includes taxes & fees

22 Nov - 23 Nov

A modern outdoor seating area with a fire pit, surrounded by wicker furniture and a landscaped garden.

5. Courtyard by Marriott St. Louis Downtown West

Downtown West, 1.1 km from Midtown

nadia

₹12,891 total

includes taxes & fees

15 Nov - 16 Nov

A modern lobby with a large glass sphere, seating areas, and a reception desk.

6. 21C Museum Hotel St Louis

Downtown West, 2.1 km from Midtown

A.R.

₹16,424 total

includes taxes & fees

22 Nov - 23 Nov

7. Pear Tree Inn St. Louis Near Union Station

Downtown West, 1.2 km from Midtown

Larry

₹11,546 total

includes taxes & fees

15 Nov - 16 Nov

An indoor pool area with a hot tub, seating, and a stone wall.

8. Drury Plaza Hotel St. Louis Union Station

Downtown West, 1.5 km from Midtown

Andrea

₹12,760 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with high ceilings, ornate columns, and a blue patterned carpet.

9. St. Louis Union Station Hotel, Curio Collection by Hilton

Downtown West, 1.7 km from Midtown

William

₹17,502 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

10. Home2 Suites by Hilton St. Louis/Forest Park

The Grove, 3 km from Midtown

Molly

₹16,963 total

includes taxes & fees

1 Dec - 2 Dec

A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

11. Embassy Suites by Hilton St. Louis Downtown

Downtown St. Louis, 3.1 km from Midtown

Megan

₹12,863 total

includes taxes & fees

23 Nov - 24 Nov

An outdoor dining area with a glass table and chairs, a neon sign, and a city view.

12. Aloft by Marriott St Louis Central West End

Central West End, 2.2 km from Midtown

Brittany

₹12,646 total

includes taxes & fees

15 Nov - 16 Nov

An indoor swimming pool with clear glass ceilings, large windows, and a sunlit area with umbrellas.

13. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Downtown St. Louis, 3.5 km from Midtown

Andrew

₹11,745 total

includes taxes & fees

22 Nov - 23 Nov

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a brick facade.

14. Comfort Inn & Suites Saint Louis Lafayette Square

The Gate, 2 km from Midtown

greg

₹11,929 total

includes taxes & fees

28 Nov - 29 Nov

A modern restaurant with geometric patterned walls, a long counter with seating, and pendant lighting.

15. Tru By Hilton St. Louis Downtown

Downtown West, 2.5 km from Midtown

Arthur

₹8,211 total

includes taxes & fees

15 Nov - 16 Nov

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

16. The Royal Sonesta Chase Park Plaza St. Louis

Central West End, 3.6 km from Midtown

Sara

₹17,805 total

includes taxes & fees

22 Nov - 23 Nov

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

17. Hyatt Regency St. Louis at The Arch

Downtown St. Louis, 3.4 km from Midtown

Tracy

₹14,009 total

includes taxes & fees

25 Nov - 26 Nov

A multi-story building with a classic architectural style, featuring numerous windows and a brick facade.

18. Courtyard by Marriott St. Louis Downtown/Convention Center

Downtown St. Louis, 2.9 km from Midtown

CESAR

₹10,943 total

includes taxes & fees

23 Nov - 24 Nov

A modern outdoor lounge area with seating, a bar, and a view of a cityscape.

19. Live by Loews - St.Louis

Downtown St. Louis, 3 km from Midtown

brandon

₹15,697 total

includes taxes & fees

15 Nov - 16 Nov

A modern interior with hanging chairs and ottomans, large windows with a view of the street.

20. Home2 Suites by Hilton St. Louis Downtown

Downtown West, 2.5 km from Midtown

blanca

₹11,231 total

includes taxes & fees

9 Nov - 10 Nov

View all properties

Compare popular hotels in Midtown

Property	Property class	Guest rating
Element by Marriott St. Louis Midtown	3.0 star property	8.8 Excellent 852 reviews	View
Residence Inn by Marriott St Louis Downtown	3.0 star property	7.6 Good 1,003 reviews	View
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton	4.0 star property	8.8 Excellent 1,172 reviews	View
Drury Plaza Hotel St. Louis Union Station	3.0 star property	9.4 Exceptional 1,606 reviews	View
Fairfield Inn & Suites by Marriott St. Louis Downtown	3.0 star property	9.2 Wonderful 1,004 reviews	View

Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Old Courthouse to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

See properties

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

See properties

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

See properties

A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

See properties

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

See properties

Top Midtown Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"The staff was excellent"

Courtyard by Marriott St. Louis Downtown/Convention Center

8/10 Good

"It was a great hotel with lovely service, clean rooms, good water pressure, extremely hot water available, soft towels, and helpful staff. The only problems I had were that the parking garage was a block over from the hotel so anytime we wanted to go anywhere, we had to walk to the next street over. It wasn’t a big deal but a slight inconvenience especially if you’re in a rush. There is a place to eat downstairs that has things like muffins, coffee, and real meals BUT it’s only open from 5pm-10pm? Just inconvenient times. Other than those things, it was great."

The West End

8/10 Good

"Nice and clean hotel but their amenities leave a lot to come up to snuff for the cost of the rooms.: They had a coffee machine in the room but no cups or cream; in the “kitchen” there was no decaf coffee, and the only tea pods were green tea; sweetener was out but few packets of cream. A chalkboard said “fruit on the weekends”—it was being brought in at 8:30, as we were on our way out the door. A sign outside said “now open”—perhaps it’s under new management??"

Search Hotels in Midtown, St. Louis

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Midtown hotels

1. Element by Marriott St. Louis Midtown

2. Residence Inn by Marriott St Louis Downtown

3. Fairfield Inn & Suites by Marriott St. Louis Downtown

4. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

5. Courtyard by Marriott St. Louis Downtown West

6. 21C Museum Hotel St Louis

7. Pear Tree Inn St. Louis Near Union Station

8. Drury Plaza Hotel St. Louis Union Station

9. St. Louis Union Station Hotel, Curio Collection by Hilton

10. Home2 Suites by Hilton St. Louis/Forest Park

11. Embassy Suites by Hilton St. Louis Downtown

12. Aloft by Marriott St Louis Central West End

13. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

14. Comfort Inn & Suites Saint Louis Lafayette Square

15. Tru By Hilton St. Louis Downtown

16. The Royal Sonesta Chase Park Plaza St. Louis

17. Hyatt Regency St. Louis at The Arch

18. Courtyard by Marriott St. Louis Downtown/Convention Center

19. Live by Loews - St.Louis

20. Home2 Suites by Hilton St. Louis Downtown

Compare popular hotels in Midtown

Where to stay in Midtown

Downtown St. Louis

Clayton

St. Charles Historic District

Central West End

Creve Coeur

Top Midtown Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Frequently asked questions

Explore a world of travel with Expedia