Midtown Travel Guide
St. Louis
Popular places to visit
St. Louis University
Explore the campus of St. Louis University during your stay in St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
Scott Joplin House State Historic Site
Learn about the local history of St. Louis when you take a trip to Scott Joplin House State Historic Site. Experience the area's great live music or attend a baseball game.
St. Louis Union Station
You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theatre scene or attend a baseball game.
Gateway Arch
Visit the Museum of Westward Expansion, then ascend to the top of the tallest man-made monument in the US for breathtaking views of St. Louis.
Enterprise Center
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's great live music or attend a baseball game.
Top hotels in Midtown
Element St. Louis Midtown
Staff members, including general manager Michael, greeted us and welcomed us immediately, accommodating an early check-in and valet parking made that process extra simple. The room is well appointed, clean, and modern. The partial kitchenette is such a wonderful addition to the spacious rooms. We ...
Reviewed on 8 Mar 2026
Residence Inn by Marriott St Louis Downtown
Could tell the room hasnt had a good cleaning, dirty floors and baseboards. Good location easy to find, the room set up was nice and lobby very pretty
Reviewed on 8 Mar 2026
Pear Tree Inn St. Louis Near Union Station
good hotel, free parking which is rare in downtown St. Louis.
Reviewed on 8 Mar 2026
Clayton Plaza Hotel & Extended Stay
I did not utilize the pool or the shop’s nearby
Reviewed on 9 Mar 2026
21C Museum Hotel St Louis
Check in was at 4pm and we arrived at 5. They said our room wasn’t ready because they were behind with cleaning. We had a concert to leave for in an hour. They offered me to get ready in the locker rooms in the gym downstairs. We didn’t get into our room until a little after 6. Room was pretty small. ...
Reviewed on 8 Mar 2026
Drury Plaza Hotel St. Louis at the Arch
We stayed 2 nights to attend a concert. There were multiple big events going on in the area and the staff was still amazing. Check in was quick. Housekeeping was polite. The building stayed clean even with the non stop traffic. Always enjoy staying at a Drury Inn!
Reviewed on 9 Mar 2026
Other neighbourhoods around Midtown
The Gate
While The Gate may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like St. Louis Union Station and Busch Stadium.
Downtown West
While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.
Lafayette Square
The restaurants and shopping are a few reasons travellers visit Lafayette Square. Want to see more of the surrounding area? St. Louis Union Station and Busch Stadium are a few top sights nearby.
The Grove
While there might not be top attractions in The Grove, you can explore the larger area and discover places like St. Louis Science Center and Missouri Botanical Gardens and Arboretum.
Shaw
Shaw might not have many top sights, but Missouri Botanical Gardens and Arboretum and St. Louis Science Center are two attractions nearby that you can check out.
Central West End
If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.
