A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Search Winery Hotels in Southeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Winery Hotels

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

Our top choices for Southeast Missouri hotels with winery

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,002 reviews)
"Everything was great about the stay!"
United States
Denise
The price is ₹8,555
₹9,580 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Poplar Bluff
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

2. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,001 reviews)
"Clean room affordable and great breakfast I would definitely go back!"
United States
Lyn
The price is ₹7,595
₹8,030 total
includes taxes & fees
8 Nov - 9 Nov
Drury Inn & Suites Jackson MO
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

3. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is ₹9,495
₹10,711 total
includes taxes & fees
8 Nov - 9 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
A modern hotel lobby with a central dining area, a minibar, and a view of the outdoors.

4. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (81 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is ₹9,266
₹10,497 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn By Hilton Dexter
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

5. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (699 reviews)
"Clean, quiet, comfortable room. Very comfortable beds."
United States
Renee
The price is ₹10,094
₹11,387 total
includes taxes & fees
3 Nov - 4 Nov
The Riverview
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

6. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,003 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is ₹6,836
₹7,712 total
includes taxes & fees
8 Nov - 9 Nov
Pear Tree Inn Cape Girardeau West
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

7. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (975 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is ₹9,201
₹10,395 total
includes taxes & fees
8 Nov - 9 Nov
Fairfield Inn & Suites by Marriott Poplar Bluff
A living room with a blue wall, a fireplace, a sofa, and a chair.

8. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (117 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is ₹9,384
₹10,215 total
includes taxes & fees
3 Dec - 4 Dec
EC Reed's Mercantile and Hotel
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (890 reviews)
"Breakfast was good."
United States
J
The price is ₹7,587
₹8,211 total
includes taxes & fees
8 Nov - 9 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A modern retail area with a display of local items and snacks.

10. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (199 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is ₹8,487
₹9,659 total
includes taxes & fees
8 Nov - 9 Nov
Tru By Hilton Cape Girardeau
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

11. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (239 reviews)
"Great hotel…!!"
United States
Carlos
The price is ₹9,605
₹10,835 total
includes taxes & fees
8 Nov - 9 Nov
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with a reception desk, seating area, and large windows.

12. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,002 reviews)
"Clean, great food, excellent staff."
United States
Dean
The price is ₹8,545
₹9,654 total
includes taxes & fees
8 Nov - 9 Nov
Drury Inn & Suites Poplar Bluff
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

13. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is ₹9,401
₹10,699 total
includes taxes & fees
30 Nov - 1 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

14. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (856 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is ₹9,266
₹10,453 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Cape Girardeau I 55 East
A spacious lobby with marble flooring, elegant seating, and a grand staircase.

15. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (556 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is ₹11,024
₹12,492 total
includes taxes & fees
15 Nov - 16 Nov
Courtyard by Marriott Cape Girardeau Downtown
A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

16. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (118 reviews)
"Recomend this location"
United States
Jose
The price is ₹8,356
₹13,807 total
includes taxes & fees
1 Dec - 2 Dec
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

17. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (337 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is ₹11,708
₹12,789 total
includes taxes & fees
3 Nov - 4 Nov
Shepherd Mountain Inn
Property amenity

18. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (29 reviews)
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
United States
Mark
The price is ₹10,350
₹11,771 total
includes taxes & fees
8 Nov - 9 Nov
TownePlace Suites by Marriott Sikeston
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

19. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,004 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is ₹6,751
₹7,559 total
includes taxes & fees
16 Nov - 17 Nov
Motel 6 Poplar Bluff, MO
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

20. Century Casino & Hotel Caruthersville

Century Casino & Hotel Caruthersville
3.0 star property
Caruthersville
8.6 out of 10, Excellent, (202 reviews)
"The Casino was clean and the staff was extremely friendly!"
United States
Jessica
The price is ₹11,537
₹13,121 total
includes taxes & fees
3 Nov - 4 Nov
Century Casino & Hotel Caruthersville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"I did a surprise overnight for my husband’s birthday! I mainly just wanted to have access to the indoor pool and hot tub! The kick back was great, breakfast was ok! We aren’t big breakfast people. We love that the staff remembered us from last year when we stayed for a week during our home renovations. Room was very clean and the beds are always very comfortable, linens were soft and very clean! We will always have our staycation at the drury"
Robin 1-night trip
Posted 15 hours ago
Drury Inn & Suites Jackson MO

Explore a world of travel with Expedia