A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Search Pet-Friendly Hotels in Southeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Pet-Friendly Hotels

Tonight
9 Oct - 10 Oct
Tomorrow
10 Oct - 11 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Southeast Missouri pet-friendly hotels

A motel with a covered entrance, a flag, and a phone number.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

1. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
₹7,839
₹8,561 total
includes taxes & fees
3 Nov - 4 Nov
Madison Inn Lodge
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

2. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
United States
Abram
₹8,651
₹9,892 total
includes taxes & fees
29 Oct - 30 Oct
Hampton Inn & Suites By Hilton Festus
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A restaurant with a brick wall, a flat-screen TV, and a bar area.

3. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Debra S
₹7,741
₹8,184 total
includes taxes & fees
13 Oct - 14 Oct
Drury Inn & Suites Jackson MO
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
Terrace/patio
Snack bar
Pool

4. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
₹8,802
₹9,856 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff
A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.
A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.
A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.
A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

5. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
Perryville
₹6,582
₹7,534 total
includes taxes & fees
8 Nov - 9 Nov
Super 8 by Wyndham Perryville
A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.
A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.
A hotel room with a large bed, a bedside table with a lamp, a vanity with a mirror, and a wall with framed pictures.
A modern hotel with a prominent 'La Quinta' sign, large windows, and a well-lit entrance.

6. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Festus
United States
Debra S
₹8,144
₹9,312 total
includes taxes & fees
13 Oct - 14 Oct
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
A living room with a blue wall, a fireplace, a sofa, and a chair.
A brick building with a sign reading "Mercantile & Hotel".
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A bar area with stools and a counter where a bartender is serving drinks.

7. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
₹10,176
₹11,077 total
includes taxes & fees
11 Oct - 12 Oct
EC Reed's Mercantile and Hotel
A hotel room with a sofa, a small table, a chair, a desk, two lamps, a window with curtains, and a framed picture on the wall.
A Holiday Inn hotel with a covered entrance, multiple flags, and a brick facade.
A hotel room with two beds, a bedside lamp, a bench, a mirror, and a door leading to another room.
A hotel room with a desk, chair, and a small seating area. It includes a microwave, coffee maker, and a refrigerator.

8. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
Poplar Bluff
₹7,646
₹8,638 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Poplar Bluff by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

9. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Curtis
₹9,677
₹10,916 total
includes taxes & fees
13 Oct - 14 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

10. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
United States
Elizabeth
₹6,968
₹7,861 total
includes taxes & fees
25 Oct - 26 Oct
Pear Tree Inn Cape Girardeau West
View all properties

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"The pillows were too hard. Maybe have 1 or 2 soft pillows in each room. Otherwise, my cousins & friend, on a girl's trip, really like Drury & will use them again. The staff working the kitchen were wonderful. Kudos to all. ☺️ Thank you."
Cynthia 1-night trip
Posted less than an hour ago
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."
Richard 1-night trip
Posted 1 hour ago
Days Inn and Suites by Wyndham Sikeston
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"The whole experience here during our stay was wonderful. Staff was friendly, everything was clean and well maintained. We would definitely stay here again."
Austin 1-night trip
Posted 3 hours ago
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

8/10 Good
"Great place, little expensive!"
Richard 1-night trip
Posted 12 hours ago
Drury Inn & Suites Hayti Caruthersville
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

8/10 Good
"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."
Jacqueline 1-night trip
Posted 7 days ago
Candlewood Suites Cape Girardeau by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"
Herman 1-night trip
Posted 7 days ago
Motel 6 Poplar Bluff, MO

Explore a world of travel with Expedia